Role of ultrasound in detection of lymph-node metastasis in gynecological cancer: systematic review and meta-analysis

Objective: To assess the diagnostic performance of transvaginal sonography (TVS) for the preoperative evaluation of lymph-node metastasis in gynecological cancer. Methods: This was a systematic review and meta-analysis of studies published between January 1990 and May 2023 evaluating the role of ult...

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Detalles Bibliográficos
Autores: Borges, A.C. (Ana Catarina)|||/items/42a9d376-9966-4eff-a0e6-cba317f50980, Veloso, H. (H)|||/items/34df541c-f123-4d30-a26b-ebf61b55bd6f, Galindo, P. (P)|||/items/217ff9d2-bd15-43c7-accc-7583ae4826cd, Danés, A. (Ariadna)|||/items/a483195f-fa5e-4fa6-a20b-5ca153a445dc, Chacón-Cruz, E.M. (Enrique María)|||/items/1a38826d-5d8f-4395-a99b-f070e88c2c72, Mínguez-Milio, J.A. (José Ángel)|||/items/c10367d9-e049-41d1-b982-eb349d28614d, Alcazar, J.L. (Juan Luis)|||/items/60547d4c-c930-4ef2-a41a-55ae849f2e96
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/70030
Acceso en línea:https://hdl.handle.net/10171/70030
Access Level:acceso abierto
Palabra clave:Cervical cancer
Endometrial cancer
Gynecological cancer
Lymph-node metastasis
Ovarian cancer
Ultrasound
Descripción
Sumario:Objective: To assess the diagnostic performance of transvaginal sonography (TVS) for the preoperative evaluation of lymph-node metastasis in gynecological cancer. Methods: This was a systematic review and meta-analysis of studies published between January 1990 and May 2023 evaluating the role of ultrasound in detecting pelvic lymph-node metastasis (index test) in gynecological cancer, using histopathological analysis as the reference standard. The quality of included studies was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 tool. Pooled sensitivity, specificity and diagnostic odds ratio were estimated. Results: The literature search identified 2638 citations. Eight studies reporting on a total of 967 women were included. The mean prevalence of pelvic lymph-node metastasis was 24.2% (range, 14.0-65.6%). The risk of bias was low for most domains assessed. Pooled sensitivity, specificity and diagnostic odds ratio of TVS were 41% (95% CI, 26-58%), 98% (95% CI, 93-99%) and 32 (95% CI, 14-72), respectively. High heterogeneity was found between studies for both sensitivity and specificity. Conclusion: TVS showed a high pooled specificity for the detection of pelvic lymph-node metastasis in gynecological cancer, but pooled sensitivity was low. © 2024 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.

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