Iodothyronine levels in the human developing brain: major regulatory roles of iodothyronine deiodinases in different areas

12 pages, 8 figures, 3 tables.-- et al.

Detalles Bibliográficos
Autores: Kester, Monique H. A., Martínez de Mena, Raquel, Obregón, María Jesús, Hume, Robert, Morreale de Escobar, Gabriella
Tipo de recurso: artículo
Fecha de publicación:2004
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/24559
Acceso en línea:http://hdl.handle.net/10261/24559
Access Level:acceso abierto
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spelling Iodothyronine levels in the human developing brain: major regulatory roles of iodothyronine deiodinases in different areasKester, Monique H. A.Martínez de Mena, RaquelObregón, María JesúsHume, RobertMorreale de Escobar, Gabriella12 pages, 8 figures, 3 tables.-- et al.Thyroid hormones are required for human brain development, but data on local regulation are limited. We describe the ontogenic changes in T(4), T(3), and rT(3) and in the activities of the types I, II, and III iodothyronine deiodinases (D1, D2, and D3) in different brain regions in normal fetuses (13-20 wk postmenstrual age) and premature infants (24-42 wk postmenstrual age). D1 activity was undetectable. The developmental changes in the concentrations of the iodothyronines and D2 and D3 activities showed spatial and temporal specificity but with divergence in the cerebral cortex and cerebellum. T(3) increased in the cortex between 13 and 20 wk to levels higher than adults, unexpected given the low circulating T(3). Considerable D2 activity was found in the cortex, which correlated positively with T(4) (r = 0.65). Cortex D3 activity was very low, as was D3 activity in germinal eminence and choroid plexus. In contrast, cerebellar T(3) was very low and increased only after midgestation. Cerebellum D3 activities were the highest (64 fmol/min.mg) of the regions studied, decreasing after midgestation. Other regions with high D3 activities (midbrain, basal ganglia, brain stem, spinal cord, hippocampus) also had low T(3) until D3 started decreasing after midgestation. D3 was correlated with T(3) (r = -0.682) and rT(3)/T(3) (r = 0.812) and rT(3)/T(4) (r = 0.889). Our data support the hypothesis that T(3) is required by the human cerebral cortex before midgestation, when mother is the only source of T(4). D2 and D3 play important roles in the local bioavailability of T(3). T(3) is produced from T(4) by D2, and D3 protects brain regions from excessive T(3) until differentiation is required.This work was supported by European Community Grant QLG-2000-00930, Netherlands Organization for Scientific Research Grant 903-40-204, Fondo de Investigacion Sanitaria RCMN (C03/08) from Inst. de Salud Carlos III, Chief Scientists Office Scottish Executive (K/MRS/50/C741), and Tenovus Scotland/Leng Trust.Peer reviewedEndocrine Society201020102004info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501563343 bytesapplication/pdfhttp://hdl.handle.net/10261/24559reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1210/jc.2003-031832info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/245592026-05-22T06:33:51Z
dc.title.none.fl_str_mv Iodothyronine levels in the human developing brain: major regulatory roles of iodothyronine deiodinases in different areas
title Iodothyronine levels in the human developing brain: major regulatory roles of iodothyronine deiodinases in different areas
spellingShingle Iodothyronine levels in the human developing brain: major regulatory roles of iodothyronine deiodinases in different areas
Kester, Monique H. A.
title_short Iodothyronine levels in the human developing brain: major regulatory roles of iodothyronine deiodinases in different areas
title_full Iodothyronine levels in the human developing brain: major regulatory roles of iodothyronine deiodinases in different areas
title_fullStr Iodothyronine levels in the human developing brain: major regulatory roles of iodothyronine deiodinases in different areas
title_full_unstemmed Iodothyronine levels in the human developing brain: major regulatory roles of iodothyronine deiodinases in different areas
title_sort Iodothyronine levels in the human developing brain: major regulatory roles of iodothyronine deiodinases in different areas
dc.creator.none.fl_str_mv Kester, Monique H. A.
Martínez de Mena, Raquel
Obregón, María Jesús
Hume, Robert
Morreale de Escobar, Gabriella
author Kester, Monique H. A.
author_facet Kester, Monique H. A.
Martínez de Mena, Raquel
Obregón, María Jesús
Hume, Robert
Morreale de Escobar, Gabriella
author_role author
author2 Martínez de Mena, Raquel
Obregón, María Jesús
Hume, Robert
Morreale de Escobar, Gabriella
author2_role author
author
author
author
description 12 pages, 8 figures, 3 tables.-- et al.
publishDate 2004
dc.date.none.fl_str_mv 2004
2010
2010
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/24559
url http://hdl.handle.net/10261/24559
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1210/jc.2003-031832
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 563343 bytes
application/pdf
dc.publisher.none.fl_str_mv Endocrine Society
publisher.none.fl_str_mv Endocrine Society
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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