Meniscal allograft transplants and new scaffolding techniques

Clinical management of meniscal injuries has changed radically in recent years. We have moved from the model of systematic tissue removal (meniscectomy) to understanding the need to preserve the tissue. Based on the increased knowledge of the basic science of meniscal functions and their role in joi...

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Autores: Pereira, Hélder, Fatih Cengiz, Ibrahim, Gomes, Sérgio, Espregueira-Mendes, João, Ripoll, Pedro L., Monllau García, Joan Carles|||0000-0002-2418-4874, Reis, Rui L., Oliveira, J. Miguel|||0000-0001-7052-8837
Formato: artículo
Fecha de publicación:2019
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:226504
Acesso em linha:https://ddd.uab.cat/record/226504
https://dx.doi.org/urn:doi:10.1302/2058-5241.4.180103
Access Level:acceso abierto
Palavra-chave:Meniscal repair
Meniscectomy
Meniscus allograft transplantation (MAT)
Partial meniscus replacement
Scaffold
Tissue engineering and regenerative medicine
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spelling Meniscal allograft transplants and new scaffolding techniquesPereira, HélderFatih Cengiz, IbrahimGomes, SérgioEspregueira-Mendes, JoãoRipoll, Pedro L.Monllau García, Joan Carles|||0000-0002-2418-4874Reis, Rui L.Oliveira, J. Miguel|||0000-0001-7052-8837Meniscal repairMeniscectomyMeniscus allograft transplantation (MAT)Partial meniscus replacementScaffoldTissue engineering and regenerative medicineClinical management of meniscal injuries has changed radically in recent years. We have moved from the model of systematic tissue removal (meniscectomy) to understanding the need to preserve the tissue. Based on the increased knowledge of the basic science of meniscal functions and their role in joint homeostasis, meniscus preservation and/or repair, whenever indicated and possible, are currently the guidelines for management. However, when repair is no longer possible or when facing the fact of the previous partial, subtotal or total loss of the meniscus, meniscus replacement has proved its clinical value. Nevertheless, meniscectomy remains amongst the most frequent orthopaedic procedures. Meniscus replacement is currently possible by means of meniscal allograft transplantation (MAT) which provides replacement of the whole meniscus with or without bone plugs/slots. Partial replacement has been achieved by means of meniscal scaffolds (mainly collagen or polyurethane-based). Despite the favourable clinical outcomes, it is still debatable whether MAT is capable of preventing progression to osteoarthritis. Moreover, current scaffolds have shown some fundamental limitations, such as the fact that the newly formed tissue may be different from the native fibrocartilage of the meniscus. Regenerative tissue engineering strategies have been used in an attempt to provide a new generation of meniscal implants, either for partial or total replacement. The goal is to provide biomaterials (acellular or cell-seeded constructs) which provide the biomechanical properties but also the biological features to replace the loss of native tissue. Moreover, these approaches include possibilities for patient-specific implants of correct size and shape, as well as advanced strategies combining cells, bioactive agents, hydrogels or gene therapy. Herein, the clinical evidence and tips concerning MAT, currently available meniscus scaffolds and future perspectives are discussed. 22019-01-0120192019-01-01Article de revisióhttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/226504https://dx.doi.org/urn:doi:10.1302/2058-5241.4.180103reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2265042026-06-06T12:50:31Z
dc.title.none.fl_str_mv Meniscal allograft transplants and new scaffolding techniques
title Meniscal allograft transplants and new scaffolding techniques
spellingShingle Meniscal allograft transplants and new scaffolding techniques
Pereira, Hélder
Meniscal repair
Meniscectomy
Meniscus allograft transplantation (MAT)
Partial meniscus replacement
Scaffold
Tissue engineering and regenerative medicine
title_short Meniscal allograft transplants and new scaffolding techniques
title_full Meniscal allograft transplants and new scaffolding techniques
title_fullStr Meniscal allograft transplants and new scaffolding techniques
title_full_unstemmed Meniscal allograft transplants and new scaffolding techniques
title_sort Meniscal allograft transplants and new scaffolding techniques
dc.creator.none.fl_str_mv Pereira, Hélder
Fatih Cengiz, Ibrahim
Gomes, Sérgio
Espregueira-Mendes, João
Ripoll, Pedro L.
Monllau García, Joan Carles|||0000-0002-2418-4874
Reis, Rui L.
Oliveira, J. Miguel|||0000-0001-7052-8837
author Pereira, Hélder
author_facet Pereira, Hélder
Fatih Cengiz, Ibrahim
Gomes, Sérgio
Espregueira-Mendes, João
Ripoll, Pedro L.
Monllau García, Joan Carles|||0000-0002-2418-4874
Reis, Rui L.
Oliveira, J. Miguel|||0000-0001-7052-8837
author_role author
author2 Fatih Cengiz, Ibrahim
Gomes, Sérgio
Espregueira-Mendes, João
Ripoll, Pedro L.
Monllau García, Joan Carles|||0000-0002-2418-4874
Reis, Rui L.
Oliveira, J. Miguel|||0000-0001-7052-8837
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Meniscal repair
Meniscectomy
Meniscus allograft transplantation (MAT)
Partial meniscus replacement
Scaffold
Tissue engineering and regenerative medicine
topic Meniscal repair
Meniscectomy
Meniscus allograft transplantation (MAT)
Partial meniscus replacement
Scaffold
Tissue engineering and regenerative medicine
description Clinical management of meniscal injuries has changed radically in recent years. We have moved from the model of systematic tissue removal (meniscectomy) to understanding the need to preserve the tissue. Based on the increased knowledge of the basic science of meniscal functions and their role in joint homeostasis, meniscus preservation and/or repair, whenever indicated and possible, are currently the guidelines for management. However, when repair is no longer possible or when facing the fact of the previous partial, subtotal or total loss of the meniscus, meniscus replacement has proved its clinical value. Nevertheless, meniscectomy remains amongst the most frequent orthopaedic procedures. Meniscus replacement is currently possible by means of meniscal allograft transplantation (MAT) which provides replacement of the whole meniscus with or without bone plugs/slots. Partial replacement has been achieved by means of meniscal scaffolds (mainly collagen or polyurethane-based). Despite the favourable clinical outcomes, it is still debatable whether MAT is capable of preventing progression to osteoarthritis. Moreover, current scaffolds have shown some fundamental limitations, such as the fact that the newly formed tissue may be different from the native fibrocartilage of the meniscus. Regenerative tissue engineering strategies have been used in an attempt to provide a new generation of meniscal implants, either for partial or total replacement. The goal is to provide biomaterials (acellular or cell-seeded constructs) which provide the biomechanical properties but also the biological features to replace the loss of native tissue. Moreover, these approaches include possibilities for patient-specific implants of correct size and shape, as well as advanced strategies combining cells, bioactive agents, hydrogels or gene therapy. Herein, the clinical evidence and tips concerning MAT, currently available meniscus scaffolds and future perspectives are discussed.
publishDate 2019
dc.date.none.fl_str_mv 2
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv Article de revisió
http://purl.org/coar/resource_type/c_dcae04bc
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/226504
https://dx.doi.org/urn:doi:10.1302/2058-5241.4.180103
url https://ddd.uab.cat/record/226504
https://dx.doi.org/urn:doi:10.1302/2058-5241.4.180103
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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