Effects of Exercise Training in Mice Models of Graft Versus Host Disease

NTRODUCTION: Chronic graft versus host disease (cGVHD) is a life-threatening complication of allogeneic hematopoietic stem cell transplantation that generates considerable morbidity and compromises the physical capacity of patients. We determined the effects of an exercise training program performed...

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Autores: Fiuza Luces, María del Carmen, González-Murillo, África, Colmenero, Isabel, Martínez Palacio, Jesús, Ramírez, Manuel, Lucía Mulas, Alejandro
Formato: artículo
Fecha de publicación:2012
País:España
Recursos:Universidad Europea (UEM)
Repositorio:ABACUS. Repositorio de Producción Científica
Idioma:inglés
OAI Identifier:oai:abacus.universidadeuropea.com:11268/714
Acesso em linha:http://hdl.handle.net/11268/714
Access Level:acceso abierto
Palavra-chave:Deporte
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spelling Effects of Exercise Training in Mice Models of Graft Versus Host DiseaseFiuza Luces, María del CarmenGonzález-Murillo, ÁfricaColmenero, IsabelMartínez Palacio, JesúsRamírez, ManuelLucía Mulas, AlejandroDeporteNTRODUCTION: Chronic graft versus host disease (cGVHD) is a life-threatening complication of allogeneic hematopoietic stem cell transplantation that generates considerable morbidity and compromises the physical capacity of patients. We determined the effects of an exercise training program performed after allogeneic hematopoietic stem cell transplantation on clinical and biological variables in a minor histocompatibility antigen-driven murine model of cGVHD treated with cyclosporine A. METHODS: Recipient BALB/C female mice (age 8 wk) received bone marrow cells and splenocytes from donor B10.D2 male mice and were randomly assigned to an exercise (n = 11) or control group (n = 12). For approximately 11 wk after transplant, the exercise group completed a moderate-intensity treadmill program. Variables assessed were clinical severity scores, survival, physical fitness, cytokine profile, immune cell reconstitution, molecular markers of muscle exercise adaptations, and histological scores in affected tissues. RESULTS: Exercise training increased survival (P = 0.011), diminished total clinical severity scores (P = 0.002), improved physical fitness (P = 0.030), and reduced blood IL-4 and tumor necrosis factor α levels (P = 0.03), while increasing circulating B220 (P = 0.008) and CD4 lymphocytes (P = 0.043). CONCLUSIONS: A moderate-intensity exercise program that mimics widely accepted public health recommendations for physical activity in human adults was well tolerated and positive effects on survival as well as on clinical and biological indicators of cGVHD.20132013-11-2720122012-01-0120122012-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articlehttp://hdl.handle.net/11268/714reponame:ABACUS. Repositorio de Producción Científicainstname:Universidad Europea (UEM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:abacus.universidadeuropea.com:11268/7142026-06-11T12:41:27Z
dc.title.none.fl_str_mv Effects of Exercise Training in Mice Models of Graft Versus Host Disease
title Effects of Exercise Training in Mice Models of Graft Versus Host Disease
spellingShingle Effects of Exercise Training in Mice Models of Graft Versus Host Disease
Fiuza Luces, María del Carmen
Deporte
title_short Effects of Exercise Training in Mice Models of Graft Versus Host Disease
title_full Effects of Exercise Training in Mice Models of Graft Versus Host Disease
title_fullStr Effects of Exercise Training in Mice Models of Graft Versus Host Disease
title_full_unstemmed Effects of Exercise Training in Mice Models of Graft Versus Host Disease
title_sort Effects of Exercise Training in Mice Models of Graft Versus Host Disease
dc.creator.none.fl_str_mv Fiuza Luces, María del Carmen
González-Murillo, África
Colmenero, Isabel
Martínez Palacio, Jesús
Ramírez, Manuel
Lucía Mulas, Alejandro
author Fiuza Luces, María del Carmen
author_facet Fiuza Luces, María del Carmen
González-Murillo, África
Colmenero, Isabel
Martínez Palacio, Jesús
Ramírez, Manuel
Lucía Mulas, Alejandro
author_role author
author2 González-Murillo, África
Colmenero, Isabel
Martínez Palacio, Jesús
Ramírez, Manuel
Lucía Mulas, Alejandro
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Deporte
topic Deporte
description NTRODUCTION: Chronic graft versus host disease (cGVHD) is a life-threatening complication of allogeneic hematopoietic stem cell transplantation that generates considerable morbidity and compromises the physical capacity of patients. We determined the effects of an exercise training program performed after allogeneic hematopoietic stem cell transplantation on clinical and biological variables in a minor histocompatibility antigen-driven murine model of cGVHD treated with cyclosporine A. METHODS: Recipient BALB/C female mice (age 8 wk) received bone marrow cells and splenocytes from donor B10.D2 male mice and were randomly assigned to an exercise (n = 11) or control group (n = 12). For approximately 11 wk after transplant, the exercise group completed a moderate-intensity treadmill program. Variables assessed were clinical severity scores, survival, physical fitness, cytokine profile, immune cell reconstitution, molecular markers of muscle exercise adaptations, and histological scores in affected tissues. RESULTS: Exercise training increased survival (P = 0.011), diminished total clinical severity scores (P = 0.002), improved physical fitness (P = 0.030), and reduced blood IL-4 and tumor necrosis factor α levels (P = 0.03), while increasing circulating B220 (P = 0.008) and CD4 lymphocytes (P = 0.043). CONCLUSIONS: A moderate-intensity exercise program that mimics widely accepted public health recommendations for physical activity in human adults was well tolerated and positive effects on survival as well as on clinical and biological indicators of cGVHD.
publishDate 2012
dc.date.none.fl_str_mv 2012
2012-01-01
2012
2012-01-01
2013
2013-11-27
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/11268/714
url http://hdl.handle.net/11268/714
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:ABACUS. Repositorio de Producción Científica
instname:Universidad Europea (UEM)
instname_str Universidad Europea (UEM)
reponame_str ABACUS. Repositorio de Producción Científica
collection ABACUS. Repositorio de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301629

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