Association of acid phosphatase locus 1*C allele with the risk of cardiovascular events in rheumatoid arthritis patients

Introduction: Acid phosphatase locus 1 (ACP1) encodes a low molecular weight phosphotyrosine phosphatase implicated in a number of different biological functions in the cell. The aim of this study was to determine the contribution of ACP1 polymorphisms to susceptibility to rheumatoid arthritis (RA),...

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Detalhes bibliográficos
Autores: Teruel, María, Martin, Jose-Ezequiel, González Juanatey, Carlos, López Mejías, Raquel, Miranda-Filloy, José A., Blanco, Ricardo, Balsa, Alejandro, Pascual-Salcedo, Dora, Rodríguez-Rodríguez, Luis, Fernández-Gutiérrez, Benjamín, Ortiz, Ana María, González Álvaro, Isidoro, Gómez Vaquero, Carmen, Bottini, Nunzio, Llorca Díaz, Javier, González-Gay, Miguel A., Martín, Javier
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2011
País:España
Recursos:Universidad de Barcelona
Repositório:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/119583
Acesso em linha:https://hdl.handle.net/2445/119583
Access Level:Acceso aberto
Palavra-chave:Artritis reumatoide
Malalties cardiovasculars
Polimorfisme genètic
Rheumatoid arthritis
Cardiovascular diseases
Genetic polymorphisms
Descrição
Resumo:Introduction: Acid phosphatase locus 1 (ACP1) encodes a low molecular weight phosphotyrosine phosphatase implicated in a number of different biological functions in the cell. The aim of this study was to determine the contribution of ACP1 polymorphisms to susceptibility to rheumatoid arthritis (RA), as well as the potential contribution of these polymorphisms to the increased risk of cardiovascular disease (CV) observed in RA patients. Methods: A set of 1,603 Spanish RA patients and 1,877 healthy controls were included in the study. Information related to the presence/absence of CV events was obtained from 1,284 of these participants. All individuals were genotyped for four ACP1 single-nucleotide polymorphisms (SNPs), rs10167992, rs11553742, rs7576247, and rs3828329, using a predesigned TaqMan SNP genotyping assay. Classical ACP1 alleles (*A, *B and *C) were imputed with SNP data. Results: No association between ACP1 gene polymorphisms and susceptibility to RA was observed. However, when RA patients were stratified according to the presence or absence of CV events, an association between rs11553742*T and CV events was found (P = 0.012, odds ratio (OR) = 2.62 (1.24 to 5.53)). Likewise, the ACP1*C allele showed evidence of association with CV events in patients with RA (P = 0.024, OR = 2.43). Conclusions: Our data show that the ACP1*C allele influences the risk of CV events in patients with RA.

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