Structural analysis and evolution of specificity of the SUMO UFD E1-E2 interactions

SUMO belongs to the ubiquitin-like family (UbL) of protein modifiers. SUMO is conserved among eukaryotes and is essential for the regulation of processes such as DNA damage repair, transcription, DNA replication and mitosis. UbL modification of proteins occurs via a specific enzymatic cascade formed...

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Detalles Bibliográficos
Autores: Liu, Bing, Lois, L. Maria|||0000-0003-0638-1484, Reverter Cendrós, David|||0000-0002-5347-0992
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:225193
Acceso en línea:https://ddd.uab.cat/record/225193
https://dx.doi.org/urn:doi:10.1038/srep41998
Access Level:acceso abierto
Palabra clave:Amino acid sequence
Catalysis
Crystallography
X-Ray
Evolution
Molecular
Humans
Phylogeny
Protein binding
Protein conformation
Saccharomyces cerevisiae
Sequence homology
Small ubiquitin-related modifier proteins
Ubiquitin-activating enzymes
Ubiquitin-conjugating enzymes
Descripción
Sumario:SUMO belongs to the ubiquitin-like family (UbL) of protein modifiers. SUMO is conserved among eukaryotes and is essential for the regulation of processes such as DNA damage repair, transcription, DNA replication and mitosis. UbL modification of proteins occurs via a specific enzymatic cascade formed by the crosstalk between the E1-activating enzyme, the E2-conjugating enzyme and the E3-ligase. An essential discrimination step in all UbL modifiers corresponds to the interaction between E1 and E2 enzymes, which is mediated by the recruitment of the E2 to the UFD domain (Ubiquitin-Fold Domain) of the E1 enzyme. To gain insights in the properties of this interface, we have compared the structures of the complexes between E1 UFD domain and E2 in human and yeast, revealing two alternative UFD platforms that interact with a conserved E2. Comparative sequence analysis of the E1 UFD domain indicates that the E2 binding region has been conserved across phylogenetic closely related species, in which higher sequence conservation can be found in the E2 binding region than in the entire UFD domain. These distinctive strategies for E1-E2 interactions through the UFD domain might be the consequence of a high selective pressure to ensure specificity of each modifier conjugation system.