The Relationship between Depressive Symptoms, Quality of Life and miRNAs 8 Years after Bariatric Surgery

Background: There are conflicting results on whether weight loss after bariatric surgery (BS) might be associated with quality of life (QoL)/depressive symptomatology. We aim to determine whether BS outcomes are associated with QoL/depressive symptomatology in studied patients at the 8-year follow-u...

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Detalles Bibliográficos
Autores: Mela, Virginia|||0000-0001-7702-0972, Agüera, Zaida|||0000-0003-4453-4939, Alvarez-Bermudez, Maria D., Martín-Reyes, Flores, Granero, Roser|||0000-0001-6308-3198, Sánchez-García, Ana, Oliva-Olivera, Wilfredo, Tomé, Monica, Moreno-Ruiz, Francisco J., Soler-Humanes, Rocío, Fernández-Serrano, Jose L., Sánchez-Gallegos, Pilar, Martínez-Moreno, Jose M., Sancho-Marín, Raquel, Fernández Aranda, Fernando|||0000-0002-2968-9898, García-Fuentes, Eduardo|||0000-0002-3491-2724, Tinahones, Francisco J.|||0000-0001-6871-4403, Garrido Sánchez, Lourdes|||0000-0003-0756-9606
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:283091
Acceso en línea:https://ddd.uab.cat/record/283091
https://dx.doi.org/urn:doi:10.3390/nu15194109
Access Level:acceso abierto
Palabra clave:SDG 3 - Good Health and Well-being
Bariatric surgery
Class III obesity
Quality of life
Depressive symptoms
Mirnas
Descripción
Sumario:Background: There are conflicting results on whether weight loss after bariatric surgery (BS) might be associated with quality of life (QoL)/depressive symptomatology. We aim to determine whether BS outcomes are associated with QoL/depressive symptomatology in studied patients at the 8-year follow-up after BS, as well as their relationship with different serum proteins and miRNAs. Methods: A total of 53 patients with class III obesity who underwent BS, and then classified into "good responders" and "non-responders" depending on the percentage of excess weight lost (%EWL) 8 years after BS (%EWL ≥ 50% and %EWL < 50%, respectively), were included. Basal serum miRNAs and different proteins were analysed, and patients completed tests to evaluate QoL/depressive symptomatology at 8 years after BS. Results: The good responders group showed higher scores on SF-36 scales of physical functioning, role functioning-physical, role functioning-emotional, body pain and global general health compared with the non-responders. The expression of hsa-miR-101-3p, hsa-miR-15a-5p, hsa-miR-29c-3p, hsa-miR-144-3p and hsa-miR-19b-3p were lower in non-responders. Hsa-miR-19b-3p was the variable associated with the response to BS in a logistic regression model. Conclusions: The mental health of patients after BS is limited by the success of the intervention. In addition, the expression of basal serum miRNAs related to depression/anxiety could predict the success of BS.

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