Effect of time of day of recreational and household physical activity on prostate and breast cancer risk (MCC-Spainstudy)

Experimental evidence indicates that exercise performed at different times of the day may affect circadian rhythms and circadian disruption has been linked to breast and prostate cancer. We examined in a population-based case-control study (MCC-Spain) if the time-of-day when physical activity is don...

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Authors: Weitzer J, Castaño-Vinyals G, Aragonés N, Gómez-Acebo I, Guevara M, Amiano P, Martín V, Molina-Barceló A, Alguacil J, Moreno V, Suarez-Calleja C, Jiménez-Moleón JJ, Marcos-Gragera R, Papantoniou K, Pérez-Gómez B, Llorca J, Ascunce N, Gil L, Gracia-Lavedan E, Casabonne D, Lope V, Pollán M, Kogevinas M
Format: article
Status:Published version
Publication Date:2021
Country:España
Institution:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repository:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p8061
Online Access:https://fisabio.portalinvestigacion.com/publicaciones/8061
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85092162057&doi=10.1002%2fijc.33310&partnerID=40&md5=c40c5fab02c3e88d10a6739add8e2ae1
Access Level:Open access
Keyword:breast
cancer
circadian disruption
physical activity
prostate
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spelling Effect of time of day of recreational and household physical activity on prostate and breast cancer risk (MCC-Spainstudy)Weitzer JCastaño-Vinyals GAragonés NGómez-Acebo IGuevara MAmiano PMartín VMolina-Barceló AAlguacil JMoreno VSuarez-Calleja CJiménez-Moleón JJMarcos-Gragera RPapantoniou KPérez-Gómez BLlorca JAscunce NGil LGracia-Lavedan ECasabonne DLope VPollán MKogevinas Mbreastcancercircadian disruptionphysical activityprostateExperimental evidence indicates that exercise performed at different times of the day may affect circadian rhythms and circadian disruption has been linked to breast and prostate cancer. We examined in a population-based case-control study (MCC-Spain) if the time-of-day when physical activity is done affects prostate and breast cancer risk. Lifetime recreational and household physical activity was assessed by in-person interviews. Information on time-of-day of activity (assessed approximately 3 years after the assessment of lifetime physical activity and confounders) was available for 781 breast cancer cases, 865 population female controls, 504 prostate cases and 645 population male controls from 10 Spanish regions, 2008-2013. We estimated odds ratios (ORs) and 95% confidence intervals (95% CI) for different activity timings compared to inactive subjects using unconditional logistic regression adjusting for confounders. Early morning (8-10am) activity was associated with a protective effect compared to no physical activity for both breast (OR = 0.74, 95% CI = 0.48-1.15) and prostate cancer (OR = 0.73, 95% CI = 0.44-1.20); meta-OR for the two cancers combined 0.74 (95%CI = 0.53-1.02). There was no effect observed for breast or prostate cancer for late morning to afternoon activity while a protective effect was also observed for evening activity only for prostate cancer (OR = 0.75, 95% CI = 0.45-1.24). Protective effects of early morning activity were more pronounced for intermediate/evening chronotypes for both cancers. This is the first population-based investigation identifying a differential effect of timing of physical activity on cancer risk with more pronounced effects for morning hour activity. Our results, if confirmed, may improve current physical activity recommendations for cancer prevention.WILEY2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/8061https://www.scopus.com/inward/record.uri?eid=2-s2.0-85092162057&doi=10.1002%2fijc.33310&partnerID=40&md5=c40c5fab02c3e88d10a6739add8e2ae1INTERNATIONAL JOURNAL OF CANCERISSN: 00207136ISSNe: 10970215reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p80612026-06-11T12:45:17Z
dc.title.none.fl_str_mv Effect of time of day of recreational and household physical activity on prostate and breast cancer risk (MCC-Spainstudy)
title Effect of time of day of recreational and household physical activity on prostate and breast cancer risk (MCC-Spainstudy)
spellingShingle Effect of time of day of recreational and household physical activity on prostate and breast cancer risk (MCC-Spainstudy)
Weitzer J
breast
cancer
circadian disruption
physical activity
prostate
title_short Effect of time of day of recreational and household physical activity on prostate and breast cancer risk (MCC-Spainstudy)
title_full Effect of time of day of recreational and household physical activity on prostate and breast cancer risk (MCC-Spainstudy)
title_fullStr Effect of time of day of recreational and household physical activity on prostate and breast cancer risk (MCC-Spainstudy)
title_full_unstemmed Effect of time of day of recreational and household physical activity on prostate and breast cancer risk (MCC-Spainstudy)
title_sort Effect of time of day of recreational and household physical activity on prostate and breast cancer risk (MCC-Spainstudy)
dc.creator.none.fl_str_mv Weitzer J
Castaño-Vinyals G
Aragonés N
Gómez-Acebo I
Guevara M
Amiano P
Martín V
Molina-Barceló A
Alguacil J
Moreno V
Suarez-Calleja C
Jiménez-Moleón JJ
Marcos-Gragera R
Papantoniou K
Pérez-Gómez B
Llorca J
Ascunce N
Gil L
Gracia-Lavedan E
Casabonne D
Lope V
Pollán M
Kogevinas M
author Weitzer J
author_facet Weitzer J
Castaño-Vinyals G
Aragonés N
Gómez-Acebo I
Guevara M
Amiano P
Martín V
Molina-Barceló A
Alguacil J
Moreno V
Suarez-Calleja C
Jiménez-Moleón JJ
Marcos-Gragera R
Papantoniou K
Pérez-Gómez B
Llorca J
Ascunce N
Gil L
Gracia-Lavedan E
Casabonne D
Lope V
Pollán M
Kogevinas M
author_role author
author2 Castaño-Vinyals G
Aragonés N
Gómez-Acebo I
Guevara M
Amiano P
Martín V
Molina-Barceló A
Alguacil J
Moreno V
Suarez-Calleja C
Jiménez-Moleón JJ
Marcos-Gragera R
Papantoniou K
Pérez-Gómez B
Llorca J
Ascunce N
Gil L
Gracia-Lavedan E
Casabonne D
Lope V
Pollán M
Kogevinas M
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv breast
cancer
circadian disruption
physical activity
prostate
topic breast
cancer
circadian disruption
physical activity
prostate
description Experimental evidence indicates that exercise performed at different times of the day may affect circadian rhythms and circadian disruption has been linked to breast and prostate cancer. We examined in a population-based case-control study (MCC-Spain) if the time-of-day when physical activity is done affects prostate and breast cancer risk. Lifetime recreational and household physical activity was assessed by in-person interviews. Information on time-of-day of activity (assessed approximately 3 years after the assessment of lifetime physical activity and confounders) was available for 781 breast cancer cases, 865 population female controls, 504 prostate cases and 645 population male controls from 10 Spanish regions, 2008-2013. We estimated odds ratios (ORs) and 95% confidence intervals (95% CI) for different activity timings compared to inactive subjects using unconditional logistic regression adjusting for confounders. Early morning (8-10am) activity was associated with a protective effect compared to no physical activity for both breast (OR = 0.74, 95% CI = 0.48-1.15) and prostate cancer (OR = 0.73, 95% CI = 0.44-1.20); meta-OR for the two cancers combined 0.74 (95%CI = 0.53-1.02). There was no effect observed for breast or prostate cancer for late morning to afternoon activity while a protective effect was also observed for evening activity only for prostate cancer (OR = 0.75, 95% CI = 0.45-1.24). Protective effects of early morning activity were more pronounced for intermediate/evening chronotypes for both cancers. This is the first population-based investigation identifying a differential effect of timing of physical activity on cancer risk with more pronounced effects for morning hour activity. Our results, if confirmed, may improve current physical activity recommendations for cancer prevention.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/8061
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85092162057&doi=10.1002%2fijc.33310&partnerID=40&md5=c40c5fab02c3e88d10a6739add8e2ae1
url https://fisabio.portalinvestigacion.com/publicaciones/8061
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85092162057&doi=10.1002%2fijc.33310&partnerID=40&md5=c40c5fab02c3e88d10a6739add8e2ae1
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv WILEY
publisher.none.fl_str_mv WILEY
dc.source.none.fl_str_mv INTERNATIONAL JOURNAL OF CANCER
ISSN: 00207136
ISSNe: 10970215
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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