Bifidobacterium infantis and Bifidobacterium breve Improve Symptomatology and Neuronal Damage in Neurodegenerative Disease: A Systematic Review

Background/Objectives: This systematic review focused on collecting the most significant findings on the impact of the administration of Bifidobacterium infantis (or Bifidobacterium longum subps. infantis) and Bifidobacterium breve, alone, in conjunction, or in combination with other strains, in the...

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Autores: Reiriz, Manuel, Beltrán Velasco, Ana Isabel, Echeverry Alzate, Víctor, Martínez Miguel, Esther, Gómez Senent, Silvia, Uceda, Sara, Clemente Suárez, Vicente Javier
Tipo de documento: artigo
Data de publicação:2025
País:España
Recursos:Universidad Europea (UEM)
Repositório:ABACUS. Repositorio de Producción Científica
Idioma:inglês
OAI Identifier:oai:abacus.universidadeuropea.com:11268/14658
Acesso em linha:http://hdl.handle.net/11268/14658
Access Level:Acceso aberto
Palavra-chave:Microbioma Gastrointestinal
Enfermedades Inflamatorias del Intestino
Ciencias médicas
Neurobiología
Sistema nervioso
Goal 3: Ensure healthy lives and promote well-being for all at all ages
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spelling Bifidobacterium infantis and Bifidobacterium breve Improve Symptomatology and Neuronal Damage in Neurodegenerative Disease: A Systematic ReviewReiriz, ManuelBeltrán Velasco, Ana IsabelEcheverry Alzate, VíctorMartínez Miguel, EstherGómez Senent, SilviaUceda, SaraClemente Suárez, Vicente JavierMicrobioma GastrointestinalEnfermedades Inflamatorias del IntestinoCiencias médicasNeurobiologíaSistema nerviosoGoal 3: Ensure healthy lives and promote well-being for all at all agesBackground/Objectives: This systematic review focused on collecting the most significant findings on the impact of the administration of Bifidobacterium infantis (or Bifidobacterium longum subps. infantis) and Bifidobacterium breve, alone, in conjunction, or in combination with other strains, in the treatment of neurodegenerative diseases including Alzheimer’s disease (AD) and Parkinson’s disease (PD). These diseases are characterized by the progressive degeneration of neurons, resulting in a broad spectrum of clinical manifestations. AD is typified by a progressive decline in cognitive abilities, while PD is marked by motor symptoms associated with the loss of dopamine (DA). Methods: Five different databases, ScienceDirect, Scopus, Wiley, PubMed, and Web of Science (WoS), were reviewed and the studies were screened for inclusion by the following criteria: (i) studies that specifically evaluated the use of Bifidobacterium infantis, Bifidobacterium longum subsp. infantis, or Bifidobacterium breve as a therapeutic intervention, either in human or animal models, in the context of neurodegenerative diseases; (ii) the studies were required to address one or more of the pathologies examined in this article, and the pathologies included, but were not limited to, neurodegeneration, Alzheimer’s disease, Parkinson’s disease, and oxidative stress; (iii) the full text was accessible online; and (iv) the article was written in English. Results: The data suggest that these probiotics have neuroprotective effects that may delay disease progression. Conclusions: This study provides updated insights into the use of these Bifidobacterium strains in neurodegenerative diseases like AD and PD, with the main limitation being the limited number of clinical trials available.20252025-05-2620252025-01-0120252025-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/11268/14658reponame:ABACUS. Repositorio de Producción Científicainstname:Universidad Europea (UEM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:abacus.universidadeuropea.com:11268/146582026-06-11T12:41:27Z
dc.title.none.fl_str_mv Bifidobacterium infantis and Bifidobacterium breve Improve Symptomatology and Neuronal Damage in Neurodegenerative Disease: A Systematic Review
title Bifidobacterium infantis and Bifidobacterium breve Improve Symptomatology and Neuronal Damage in Neurodegenerative Disease: A Systematic Review
spellingShingle Bifidobacterium infantis and Bifidobacterium breve Improve Symptomatology and Neuronal Damage in Neurodegenerative Disease: A Systematic Review
Reiriz, Manuel
Microbioma Gastrointestinal
Enfermedades Inflamatorias del Intestino
Ciencias médicas
Neurobiología
Sistema nervioso
Goal 3: Ensure healthy lives and promote well-being for all at all ages
title_short Bifidobacterium infantis and Bifidobacterium breve Improve Symptomatology and Neuronal Damage in Neurodegenerative Disease: A Systematic Review
title_full Bifidobacterium infantis and Bifidobacterium breve Improve Symptomatology and Neuronal Damage in Neurodegenerative Disease: A Systematic Review
title_fullStr Bifidobacterium infantis and Bifidobacterium breve Improve Symptomatology and Neuronal Damage in Neurodegenerative Disease: A Systematic Review
title_full_unstemmed Bifidobacterium infantis and Bifidobacterium breve Improve Symptomatology and Neuronal Damage in Neurodegenerative Disease: A Systematic Review
title_sort Bifidobacterium infantis and Bifidobacterium breve Improve Symptomatology and Neuronal Damage in Neurodegenerative Disease: A Systematic Review
dc.creator.none.fl_str_mv Reiriz, Manuel
Beltrán Velasco, Ana Isabel
Echeverry Alzate, Víctor
Martínez Miguel, Esther
Gómez Senent, Silvia
Uceda, Sara
Clemente Suárez, Vicente Javier
author Reiriz, Manuel
author_facet Reiriz, Manuel
Beltrán Velasco, Ana Isabel
Echeverry Alzate, Víctor
Martínez Miguel, Esther
Gómez Senent, Silvia
Uceda, Sara
Clemente Suárez, Vicente Javier
author_role author
author2 Beltrán Velasco, Ana Isabel
Echeverry Alzate, Víctor
Martínez Miguel, Esther
Gómez Senent, Silvia
Uceda, Sara
Clemente Suárez, Vicente Javier
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Microbioma Gastrointestinal
Enfermedades Inflamatorias del Intestino
Ciencias médicas
Neurobiología
Sistema nervioso
Goal 3: Ensure healthy lives and promote well-being for all at all ages
topic Microbioma Gastrointestinal
Enfermedades Inflamatorias del Intestino
Ciencias médicas
Neurobiología
Sistema nervioso
Goal 3: Ensure healthy lives and promote well-being for all at all ages
description Background/Objectives: This systematic review focused on collecting the most significant findings on the impact of the administration of Bifidobacterium infantis (or Bifidobacterium longum subps. infantis) and Bifidobacterium breve, alone, in conjunction, or in combination with other strains, in the treatment of neurodegenerative diseases including Alzheimer’s disease (AD) and Parkinson’s disease (PD). These diseases are characterized by the progressive degeneration of neurons, resulting in a broad spectrum of clinical manifestations. AD is typified by a progressive decline in cognitive abilities, while PD is marked by motor symptoms associated with the loss of dopamine (DA). Methods: Five different databases, ScienceDirect, Scopus, Wiley, PubMed, and Web of Science (WoS), were reviewed and the studies were screened for inclusion by the following criteria: (i) studies that specifically evaluated the use of Bifidobacterium infantis, Bifidobacterium longum subsp. infantis, or Bifidobacterium breve as a therapeutic intervention, either in human or animal models, in the context of neurodegenerative diseases; (ii) the studies were required to address one or more of the pathologies examined in this article, and the pathologies included, but were not limited to, neurodegeneration, Alzheimer’s disease, Parkinson’s disease, and oxidative stress; (iii) the full text was accessible online; and (iv) the article was written in English. Results: The data suggest that these probiotics have neuroprotective effects that may delay disease progression. Conclusions: This study provides updated insights into the use of these Bifidobacterium strains in neurodegenerative diseases like AD and PD, with the main limitation being the limited number of clinical trials available.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-05-26
2025
2025-01-01
2025
2025-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/11268/14658
url http://hdl.handle.net/11268/14658
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:ABACUS. Repositorio de Producción Científica
instname:Universidad Europea (UEM)
instname_str Universidad Europea (UEM)
reponame_str ABACUS. Repositorio de Producción Científica
collection ABACUS. Repositorio de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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