Lyophilized maqui (Aristotelia chilensis) berry induces browning in the subcutaneous white adipose tissue and ameliorates the insulin resistance in high fat diet-induced obese mice

Maqui (Aristotelia Chilensis) berry features a unique profile of anthocyanidins that includes high amounts of delphinidin-3-O-sambubioside-5-O-glucoside and delphinidin-3-O-sambubioside and has shown positive effects on fasting glucose and insulin levels in humans and murine models of type 2 diabete...

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Autores: Sandoval, Viviana, Femenias, Antoni, Martínez-Garza, Úrsula, Sanz-Lamora, Hèctor, Castagnini, Juan Manuel, Quifer Rada, Paola, Lamuela Raventós, Rosa Ma., Marrero González, Pedro F., Haro, Diego, Relat, Joana
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2019
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/67763
Acesso em linha:https://doi.org/10.3390/antiox8090360
http://hdl.handle.net/10459.1/67763
Access Level:Acceso aberto
Palavra-chave:Anthocyanins
High-fat diet
Maqui berry
White adipose tissue
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spelling Lyophilized maqui (Aristotelia chilensis) berry induces browning in the subcutaneous white adipose tissue and ameliorates the insulin resistance in high fat diet-induced obese miceSandoval, VivianaFemenias, AntoniMartínez-Garza, ÚrsulaSanz-Lamora, HèctorCastagnini, Juan ManuelQuifer Rada, PaolaLamuela Raventós, Rosa Ma.Marrero González, Pedro F.Haro, DiegoRelat, JoanaAnthocyaninsHigh-fat dietMaqui berryWhite adipose tissueMaqui (Aristotelia Chilensis) berry features a unique profile of anthocyanidins that includes high amounts of delphinidin-3-O-sambubioside-5-O-glucoside and delphinidin-3-O-sambubioside and has shown positive effects on fasting glucose and insulin levels in humans and murine models of type 2 diabetes and obesity. The molecular mechanisms underlying the impact of maqui on the onset and development of the obese phenotype and insulin resistance was investigated in high fat diet-induced obese mice supplemented with a lyophilized maqui berry. Maqui-dietary supplemented animals showed better insulin response and decreased weight gain but also a differential expression of genes involved in de novo lipogenesis, fatty acid oxidation, multilocular lipid droplet formation and thermogenesis in subcutaneous white adipose tissue (scWAT). These changes correlated with an increased expression of the carbohydrate response element binding protein b (Chrebpb), the sterol regulatory binding protein 1c (Srebp1c) and Cellular repressor of adenovirus early region 1A–stimulated genes 1 (Creg1) and an improvement in the fibroblast growth factor 21 (FGF21) signaling. Our evidence suggests that maqui dietary supplementation activates the induction of fuel storage and thermogenesis characteristic of a brown-like phenotype in scWAT and counteracts the unhealthy metabolic impact of an HFD. This induction constitutes a putative strategy to prevent/treat diet-induced obesity and its associated comorbidities.This study was supported by the Ministerio de Economía y Competitividad (grants AGL2017-82417-R to PFM and DH and AGL2016-75329-R to RML-R), by the Generalitat (grants 2017SGR683 and 2017SGR196), by the Associació Catalana de la Diabetis to JR (grant 600004—Ajut ACD a la recerca en diabetis 2017), Instituto de Salud Carlos III, ISCIII from the Ministerio de Ciencia, Innovación y Universidades (CIBEROBN—AEI/FEDER, UE). VS was supported by Conicyt’s fellowship from the Government of Chile. UM-G was supported by Conacyt’s fellowship from the Government of México. JMC was supported by BEC.AR fellowship from Ministerio de Educación, Cultura, Ciencia y Tecnología, Argentina. The APC was funded by the University of Barcelona.MDPI201920192019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.3390/antiox8090360http://hdl.handle.net/10459.1/67763http://hdl.handle.net/10459.1/67763reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-82417-Rinfo:eu-repo/grantAgreement/MINECO//AGL2016-75329-RReproducció del document publicat a: https://doi.org/10.3390/antiox8090360Antioxidants, 2019, vol. 8, núm. 9, article number 360cc-by (c) Sandoval et al., 2019info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/4.0/oai:recercat.cat:10459.1/677632026-05-29T05:05:01Z
dc.title.none.fl_str_mv Lyophilized maqui (Aristotelia chilensis) berry induces browning in the subcutaneous white adipose tissue and ameliorates the insulin resistance in high fat diet-induced obese mice
title Lyophilized maqui (Aristotelia chilensis) berry induces browning in the subcutaneous white adipose tissue and ameliorates the insulin resistance in high fat diet-induced obese mice
spellingShingle Lyophilized maqui (Aristotelia chilensis) berry induces browning in the subcutaneous white adipose tissue and ameliorates the insulin resistance in high fat diet-induced obese mice
Sandoval, Viviana
Anthocyanins
High-fat diet
Maqui berry
White adipose tissue
title_short Lyophilized maqui (Aristotelia chilensis) berry induces browning in the subcutaneous white adipose tissue and ameliorates the insulin resistance in high fat diet-induced obese mice
title_full Lyophilized maqui (Aristotelia chilensis) berry induces browning in the subcutaneous white adipose tissue and ameliorates the insulin resistance in high fat diet-induced obese mice
title_fullStr Lyophilized maqui (Aristotelia chilensis) berry induces browning in the subcutaneous white adipose tissue and ameliorates the insulin resistance in high fat diet-induced obese mice
title_full_unstemmed Lyophilized maqui (Aristotelia chilensis) berry induces browning in the subcutaneous white adipose tissue and ameliorates the insulin resistance in high fat diet-induced obese mice
title_sort Lyophilized maqui (Aristotelia chilensis) berry induces browning in the subcutaneous white adipose tissue and ameliorates the insulin resistance in high fat diet-induced obese mice
dc.creator.none.fl_str_mv Sandoval, Viviana
Femenias, Antoni
Martínez-Garza, Úrsula
Sanz-Lamora, Hèctor
Castagnini, Juan Manuel
Quifer Rada, Paola
Lamuela Raventós, Rosa Ma.
Marrero González, Pedro F.
Haro, Diego
Relat, Joana
author Sandoval, Viviana
author_facet Sandoval, Viviana
Femenias, Antoni
Martínez-Garza, Úrsula
Sanz-Lamora, Hèctor
Castagnini, Juan Manuel
Quifer Rada, Paola
Lamuela Raventós, Rosa Ma.
Marrero González, Pedro F.
Haro, Diego
Relat, Joana
author_role author
author2 Femenias, Antoni
Martínez-Garza, Úrsula
Sanz-Lamora, Hèctor
Castagnini, Juan Manuel
Quifer Rada, Paola
Lamuela Raventós, Rosa Ma.
Marrero González, Pedro F.
Haro, Diego
Relat, Joana
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Anthocyanins
High-fat diet
Maqui berry
White adipose tissue
topic Anthocyanins
High-fat diet
Maqui berry
White adipose tissue
description Maqui (Aristotelia Chilensis) berry features a unique profile of anthocyanidins that includes high amounts of delphinidin-3-O-sambubioside-5-O-glucoside and delphinidin-3-O-sambubioside and has shown positive effects on fasting glucose and insulin levels in humans and murine models of type 2 diabetes and obesity. The molecular mechanisms underlying the impact of maqui on the onset and development of the obese phenotype and insulin resistance was investigated in high fat diet-induced obese mice supplemented with a lyophilized maqui berry. Maqui-dietary supplemented animals showed better insulin response and decreased weight gain but also a differential expression of genes involved in de novo lipogenesis, fatty acid oxidation, multilocular lipid droplet formation and thermogenesis in subcutaneous white adipose tissue (scWAT). These changes correlated with an increased expression of the carbohydrate response element binding protein b (Chrebpb), the sterol regulatory binding protein 1c (Srebp1c) and Cellular repressor of adenovirus early region 1A–stimulated genes 1 (Creg1) and an improvement in the fibroblast growth factor 21 (FGF21) signaling. Our evidence suggests that maqui dietary supplementation activates the induction of fuel storage and thermogenesis characteristic of a brown-like phenotype in scWAT and counteracts the unhealthy metabolic impact of an HFD. This induction constitutes a putative strategy to prevent/treat diet-induced obesity and its associated comorbidities.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3390/antiox8090360
http://hdl.handle.net/10459.1/67763
http://hdl.handle.net/10459.1/67763
url https://doi.org/10.3390/antiox8090360
http://hdl.handle.net/10459.1/67763
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-82417-R
info:eu-repo/grantAgreement/MINECO//AGL2016-75329-R
Reproducció del document publicat a: https://doi.org/10.3390/antiox8090360
Antioxidants, 2019, vol. 8, núm. 9, article number 360
dc.rights.none.fl_str_mv cc-by (c) Sandoval et al., 2019
info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by (c) Sandoval et al., 2019
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
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