Relationships of Perfluorooctanoate and Perfluorooctane Sulfonate Serum Concentrations between Mother-Child Pairs in a Population with Perfluorooctanoate Exposure from Drinking Water

BACKGROUND: There are limited data on the associations between maternal or newborn and child exposure to perfluoroalkyl acids (PFAAs), including perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS). This study provides an opportunity to assess the association between PFAA concentrations in...

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Authors: Mondal, D, Lopez-Espinosa, MJ, Armstrong, B, Stein, CR, Fletcher, T
Format: article
Status:Published version
Publication Date:2012
Country:España
Institution:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repository:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p16516
Online Access:https://fisabio.portalinvestigacion.com/publicaciones/16516
Access Level:Open access
Keyword:mother-child pairs
drinking water
in utero exposure
lactation
Mid-Ohio Valley
PFOA
PFOS
serum concentration
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spelling Relationships of Perfluorooctanoate and Perfluorooctane Sulfonate Serum Concentrations between Mother-Child Pairs in a Population with Perfluorooctanoate Exposure from Drinking WaterMondal, DLopez-Espinosa, MJArmstrong, BStein, CRFletcher, Tmother-child pairsdrinking waterin utero exposurelactationMid-Ohio ValleyPFOAPFOSserum concentrationBACKGROUND: There are limited data on the associations between maternal or newborn and child exposure to perfluoroalkyl acids (PFAAs), including perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS). This study provides an opportunity to assess the association between PFAA concentrations in mother-child pairs in a population exposed to PFOA via drinking water. OBJECTIVES: We aimed to determine the relationship between mother-child PFAA serum concentrations and to examine how the child: mother ratio varies with child's age, child's sex, drinking-water PFOA concentration, reported bottled water use, and mother's breast-feeding intention. METHODS: We studied 4,943 mother-child pairs (children, 1-19 years of age). The child: mother PFAA ratio was stratified by possible determinants. Results are summarized as geometric mean ratios and correlation coefficients between mother-child pairs, overall and within strata. RESULTS: Child and mother PFOA and PFOS concentrations were correlated (r = 0.82 and 0.26, respectively). Up to about 12 years of age, children had higher serum PFOA concentrations than did their mothers. The highest child: mother PFOA ratio was found among children <= 5 years (44% higher than their mothers), which we attribute to in utero exposure and to exposure via breast milk and drinking water. Higher PFOS concentrations in children persisted until at least 19 years of age (42% higher than their mothers). Boys > 5 years of age had significantly higher PFOA and PFOS child: mother ratios than did girls. CONCLUSION: Concentrations of both PFOA and PFOS tended to be higher in children than in their mothers. This difference persisted until they were about 12 years of age for PFOA and at least 19 years of age for PFOS.US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE2012info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/16516ENVIRONMENTAL HEALTH PERSPECTIVESISSN: 00916765ISSNe: 15529924reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p165162026-06-11T12:45:17Z
dc.title.none.fl_str_mv Relationships of Perfluorooctanoate and Perfluorooctane Sulfonate Serum Concentrations between Mother-Child Pairs in a Population with Perfluorooctanoate Exposure from Drinking Water
title Relationships of Perfluorooctanoate and Perfluorooctane Sulfonate Serum Concentrations between Mother-Child Pairs in a Population with Perfluorooctanoate Exposure from Drinking Water
spellingShingle Relationships of Perfluorooctanoate and Perfluorooctane Sulfonate Serum Concentrations between Mother-Child Pairs in a Population with Perfluorooctanoate Exposure from Drinking Water
Mondal, D
mother-child pairs
drinking water
in utero exposure
lactation
Mid-Ohio Valley
PFOA
PFOS
serum concentration
title_short Relationships of Perfluorooctanoate and Perfluorooctane Sulfonate Serum Concentrations between Mother-Child Pairs in a Population with Perfluorooctanoate Exposure from Drinking Water
title_full Relationships of Perfluorooctanoate and Perfluorooctane Sulfonate Serum Concentrations between Mother-Child Pairs in a Population with Perfluorooctanoate Exposure from Drinking Water
title_fullStr Relationships of Perfluorooctanoate and Perfluorooctane Sulfonate Serum Concentrations between Mother-Child Pairs in a Population with Perfluorooctanoate Exposure from Drinking Water
title_full_unstemmed Relationships of Perfluorooctanoate and Perfluorooctane Sulfonate Serum Concentrations between Mother-Child Pairs in a Population with Perfluorooctanoate Exposure from Drinking Water
title_sort Relationships of Perfluorooctanoate and Perfluorooctane Sulfonate Serum Concentrations between Mother-Child Pairs in a Population with Perfluorooctanoate Exposure from Drinking Water
dc.creator.none.fl_str_mv Mondal, D
Lopez-Espinosa, MJ
Armstrong, B
Stein, CR
Fletcher, T
author Mondal, D
author_facet Mondal, D
Lopez-Espinosa, MJ
Armstrong, B
Stein, CR
Fletcher, T
author_role author
author2 Lopez-Espinosa, MJ
Armstrong, B
Stein, CR
Fletcher, T
author2_role author
author
author
author
dc.subject.none.fl_str_mv mother-child pairs
drinking water
in utero exposure
lactation
Mid-Ohio Valley
PFOA
PFOS
serum concentration
topic mother-child pairs
drinking water
in utero exposure
lactation
Mid-Ohio Valley
PFOA
PFOS
serum concentration
description BACKGROUND: There are limited data on the associations between maternal or newborn and child exposure to perfluoroalkyl acids (PFAAs), including perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS). This study provides an opportunity to assess the association between PFAA concentrations in mother-child pairs in a population exposed to PFOA via drinking water. OBJECTIVES: We aimed to determine the relationship between mother-child PFAA serum concentrations and to examine how the child: mother ratio varies with child's age, child's sex, drinking-water PFOA concentration, reported bottled water use, and mother's breast-feeding intention. METHODS: We studied 4,943 mother-child pairs (children, 1-19 years of age). The child: mother PFAA ratio was stratified by possible determinants. Results are summarized as geometric mean ratios and correlation coefficients between mother-child pairs, overall and within strata. RESULTS: Child and mother PFOA and PFOS concentrations were correlated (r = 0.82 and 0.26, respectively). Up to about 12 years of age, children had higher serum PFOA concentrations than did their mothers. The highest child: mother PFOA ratio was found among children <= 5 years (44% higher than their mothers), which we attribute to in utero exposure and to exposure via breast milk and drinking water. Higher PFOS concentrations in children persisted until at least 19 years of age (42% higher than their mothers). Boys > 5 years of age had significantly higher PFOA and PFOS child: mother ratios than did girls. CONCLUSION: Concentrations of both PFOA and PFOS tended to be higher in children than in their mothers. This difference persisted until they were about 12 years of age for PFOA and at least 19 years of age for PFOS.
publishDate 2012
dc.date.none.fl_str_mv 2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/16516
url https://fisabio.portalinvestigacion.com/publicaciones/16516
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
publisher.none.fl_str_mv US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
dc.source.none.fl_str_mv ENVIRONMENTAL HEALTH PERSPECTIVES
ISSN: 00916765
ISSNe: 15529924
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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