Single and repeated bleomycin intratracheal instillations lead to different biomechanical changes in lung tissue

El pdf del artículo es la versión post-print.

Detalhes bibliográficos
Autores: Pinart, Mariona, Serrano-Mollar, Anna, Llatjós, R., Rocco, P. R. M., Romero, Pablo V.
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2009
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:dnet:digitalcsic_::fa911f81e57b0c9a66383deb8df0136b
Acesso em linha:http://hdl.handle.net/10261/33413
Access Level:acceso abierto
Palavra-chave:Bleomycin
Acute alveolitis
Myeloperoxydase
Interstitial lung diseases
Lung mechanics
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spelling Single and repeated bleomycin intratracheal instillations lead to different biomechanical changes in lung tissuePinart, MarionaSerrano-Mollar, AnnaLlatjós, R.Rocco, P. R. M.Romero, Pablo V.BleomycinAcute alveolitisMyeloperoxydaseInterstitial lung diseasesLung mechanicsEl pdf del artículo es la versión post-print.Single dose of bleomycin induces acute alveolitis followed by a reparative process whilst a repeated dose results in progressive fibrosis, which may lead to distinct lung tissue biomechanical changes. To test this hypothesis, rats were intratracheally instilled with saline (N = 11) or bleomycin (2.5 U/kg) once (SD, N = 8) or three times (RD, N = 9) one week apart, and sacrificed 28 days after challenge. Forced oscillatory mechanics as well as the amount of collagen fibre and myeloperoxidase content (MPOL) were studied in lung tissue strips. Both elastic modulus (H), tissue damping (G), and MPOL increased only in RD-challenged rats. Although fibroblast focus was found in RD, collagen fibre content increased in both challenged groups. However, the amount of collagen fibre in SD group was not enough to induce lung tissue mechanical changes. In conclusion, repeated doses of bleomycin induce inflammatory and fibrogenic behaviour with biomechanical changes mimicking interstitial lung disease in humans.This study was supported by FISS (PI 04/0671) Spain, Mariona Pinart is granted by a Research Scholarship of IDIBELL.Peer reviewedElsevier201120112009info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/33413reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1016/j.resp.2009.01.002info:eu-repo/semantics/openAccessoai:dnet:digitalcsic_::fa911f81e57b0c9a66383deb8df0136b2026-05-22T06:33:51Z
dc.title.none.fl_str_mv Single and repeated bleomycin intratracheal instillations lead to different biomechanical changes in lung tissue
title Single and repeated bleomycin intratracheal instillations lead to different biomechanical changes in lung tissue
spellingShingle Single and repeated bleomycin intratracheal instillations lead to different biomechanical changes in lung tissue
Pinart, Mariona
Bleomycin
Acute alveolitis
Myeloperoxydase
Interstitial lung diseases
Lung mechanics
title_short Single and repeated bleomycin intratracheal instillations lead to different biomechanical changes in lung tissue
title_full Single and repeated bleomycin intratracheal instillations lead to different biomechanical changes in lung tissue
title_fullStr Single and repeated bleomycin intratracheal instillations lead to different biomechanical changes in lung tissue
title_full_unstemmed Single and repeated bleomycin intratracheal instillations lead to different biomechanical changes in lung tissue
title_sort Single and repeated bleomycin intratracheal instillations lead to different biomechanical changes in lung tissue
dc.creator.none.fl_str_mv Pinart, Mariona
Serrano-Mollar, Anna
Llatjós, R.
Rocco, P. R. M.
Romero, Pablo V.
author Pinart, Mariona
author_facet Pinart, Mariona
Serrano-Mollar, Anna
Llatjós, R.
Rocco, P. R. M.
Romero, Pablo V.
author_role author
author2 Serrano-Mollar, Anna
Llatjós, R.
Rocco, P. R. M.
Romero, Pablo V.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Bleomycin
Acute alveolitis
Myeloperoxydase
Interstitial lung diseases
Lung mechanics
topic Bleomycin
Acute alveolitis
Myeloperoxydase
Interstitial lung diseases
Lung mechanics
description El pdf del artículo es la versión post-print.
publishDate 2009
dc.date.none.fl_str_mv 2009
2011
2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/33413
url http://hdl.handle.net/10261/33413
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1016/j.resp.2009.01.002
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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