Research on Skeletal Muscle Diseases Using Pluripotent Stem Cells

The generation of induced pluripotent stem cells (iPSCs), especially the generation of patient-derived pluripotent stem cells (PSCs) suitable for disease modelling in vitro, opens the door for the potential translation of stem-cell related studies into the clinic. Successful replacement, or augmenta...

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Autores: Oñate, Lorena de, Garreta, Elena, Tarantino, Carolina, Martínez Fraiz, Elena, Capilla Campos, Encarnación, Navarro Álvarez, Isabel, Gutiérrez Fruitós, Joaquín, Samitier i Martí, Josep, Campistol Plana, Josep M., Muñoz Cánoves, Pura, 1962-, Montserrat Pulido, Núria
Tipo de recurso: capítulo de libro
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/175835
Acceso en línea:https://hdl.handle.net/2445/175835
Access Level:acceso abierto
Palabra clave:Cèl·lules mare
Distròfia muscular
Stem cells
Muscular dystrophy
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spelling Research on Skeletal Muscle Diseases Using Pluripotent Stem CellsOñate, Lorena deGarreta, ElenaTarantino, CarolinaMartínez Fraiz, ElenaCapilla Campos, EncarnaciónNavarro Álvarez, IsabelGutiérrez Fruitós, JoaquínSamitier i Martí, JosepCampistol Plana, Josep M.Muñoz Cánoves, Pura, 1962-Montserrat Pulido, NúriaCèl·lules mareDistròfia muscularStem cellsMuscular dystrophyThe generation of induced pluripotent stem cells (iPSCs), especially the generation of patient-derived pluripotent stem cells (PSCs) suitable for disease modelling in vitro, opens the door for the potential translation of stem-cell related studies into the clinic. Successful replacement, or augmentation, of the function of damaged cells by patientderived differentiated stem cells would provide a novel cell-based therapy for skeletal muscle-related diseases. Since iPSCs resemble human embryonic stem cells (hESCs) in their ability to generate cells of the three germ layers, patient-specific iPSCs offer definitive solutions for the ethical and histo-incompatibility issues related to hESCs. Indeed human iPSC (hiPSC)-based autologous transplantation is heralded as the future of regenerative medicine. Interestingly, during the last years intense research has been published on disease-specific hiPSCs derivation and differentiation into relevant tissues/organs providing a unique scenario for modelling disease progression, to screen patient-specific drugs and enabling immunosupression-free cell replacement therapies. Here, we revise the most relevant findings in skeletal muscle differentiation using mouse and human PSCs. Finally and in an effort to bring iPSC technology to the daily routine of the laboratory, we provide two different protocols for the generation of patient-derived iPSCs.IntechOpen2015info:eu-repo/semantics/bookPartinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/175835Llibres / Capítols de llibre (Biologia Cel·lular, Fisiologia i Immunologia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReprodució del document publicat a: http://dx.doi.org/10.5772/60902Chapter 12 in: Sakuma, Kunihiro. 2015. Muscle Cell and Tissue. IntechOpen. ISBN: 978-953-51-4218-8. DOI: DOI: 10.5772/59347 pp: 333-357.http://dx.doi.org/10.5772/60902cc by (c) Oñate, Lorena de et al., 2015http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1758352026-05-27T06:46:51Z
dc.title.none.fl_str_mv Research on Skeletal Muscle Diseases Using Pluripotent Stem Cells
title Research on Skeletal Muscle Diseases Using Pluripotent Stem Cells
spellingShingle Research on Skeletal Muscle Diseases Using Pluripotent Stem Cells
Oñate, Lorena de
Cèl·lules mare
Distròfia muscular
Stem cells
Muscular dystrophy
title_short Research on Skeletal Muscle Diseases Using Pluripotent Stem Cells
title_full Research on Skeletal Muscle Diseases Using Pluripotent Stem Cells
title_fullStr Research on Skeletal Muscle Diseases Using Pluripotent Stem Cells
title_full_unstemmed Research on Skeletal Muscle Diseases Using Pluripotent Stem Cells
title_sort Research on Skeletal Muscle Diseases Using Pluripotent Stem Cells
dc.creator.none.fl_str_mv Oñate, Lorena de
Garreta, Elena
Tarantino, Carolina
Martínez Fraiz, Elena
Capilla Campos, Encarnación
Navarro Álvarez, Isabel
Gutiérrez Fruitós, Joaquín
Samitier i Martí, Josep
Campistol Plana, Josep M.
Muñoz Cánoves, Pura, 1962-
Montserrat Pulido, Núria
author Oñate, Lorena de
author_facet Oñate, Lorena de
Garreta, Elena
Tarantino, Carolina
Martínez Fraiz, Elena
Capilla Campos, Encarnación
Navarro Álvarez, Isabel
Gutiérrez Fruitós, Joaquín
Samitier i Martí, Josep
Campistol Plana, Josep M.
Muñoz Cánoves, Pura, 1962-
Montserrat Pulido, Núria
author_role author
author2 Garreta, Elena
Tarantino, Carolina
Martínez Fraiz, Elena
Capilla Campos, Encarnación
Navarro Álvarez, Isabel
Gutiérrez Fruitós, Joaquín
Samitier i Martí, Josep
Campistol Plana, Josep M.
Muñoz Cánoves, Pura, 1962-
Montserrat Pulido, Núria
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cèl·lules mare
Distròfia muscular
Stem cells
Muscular dystrophy
topic Cèl·lules mare
Distròfia muscular
Stem cells
Muscular dystrophy
description The generation of induced pluripotent stem cells (iPSCs), especially the generation of patient-derived pluripotent stem cells (PSCs) suitable for disease modelling in vitro, opens the door for the potential translation of stem-cell related studies into the clinic. Successful replacement, or augmentation, of the function of damaged cells by patientderived differentiated stem cells would provide a novel cell-based therapy for skeletal muscle-related diseases. Since iPSCs resemble human embryonic stem cells (hESCs) in their ability to generate cells of the three germ layers, patient-specific iPSCs offer definitive solutions for the ethical and histo-incompatibility issues related to hESCs. Indeed human iPSC (hiPSC)-based autologous transplantation is heralded as the future of regenerative medicine. Interestingly, during the last years intense research has been published on disease-specific hiPSCs derivation and differentiation into relevant tissues/organs providing a unique scenario for modelling disease progression, to screen patient-specific drugs and enabling immunosupression-free cell replacement therapies. Here, we revise the most relevant findings in skeletal muscle differentiation using mouse and human PSCs. Finally and in an effort to bring iPSC technology to the daily routine of the laboratory, we provide two different protocols for the generation of patient-derived iPSCs.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/bookPart
info:eu-repo/semantics/publishedVersion
format bookPart
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/175835
url https://hdl.handle.net/2445/175835
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reprodució del document publicat a: http://dx.doi.org/10.5772/60902
Chapter 12 in: Sakuma, Kunihiro. 2015. Muscle Cell and Tissue. IntechOpen. ISBN: 978-953-51-4218-8. DOI: DOI: 10.5772/59347 pp: 333-357.
http://dx.doi.org/10.5772/60902
dc.rights.none.fl_str_mv cc by (c) Oñate, Lorena de et al., 2015
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Oñate, Lorena de et al., 2015
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv IntechOpen
publisher.none.fl_str_mv IntechOpen
dc.source.none.fl_str_mv Llibres / Capítols de llibre (Biologia Cel·lular, Fisiologia i Immunologia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301629

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