Compensatory anabolic signaling in the sarcopenia of experimental chronic arthritis

Inflammatory activity in rheumatoid arthritis may alter the regulation of muscle mass leading to a secondary sarcopenia, commonly termed rheumatoid cachexia (RC). We characterized alterations to muscle structure and various pro-inflammatory, catabolic and regenerative markers in an animal model of R...

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Autores: Little, Robert D., Prieto-Potin, Iván, Pérez-Baos, Sandra, Villalvilla, Amanda, Gratal, Paula, Cicuttini, Flavia, Largo, Raquel, Herrero-Beaumont Cuenca, Gabriel
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/680224
Acceso en línea:http://hdl.handle.net/10486/680224
https://dx.doi.org/10.1038/s41598-017-06581-6
Access Level:acceso abierto
Palabra clave:Arthritis
Sarcopenia
Chronic arthritis
Compensatory anabolic
Medicina
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spelling Compensatory anabolic signaling in the sarcopenia of experimental chronic arthritisLittle, Robert D.Prieto-Potin, IvánPérez-Baos, SandraVillalvilla, AmandaGratal, PaulaCicuttini, FlaviaLargo, RaquelHerrero-Beaumont Cuenca, GabrielArthritisSarcopeniaChronic arthritisCompensatory anabolicMedicinaInflammatory activity in rheumatoid arthritis may alter the regulation of muscle mass leading to a secondary sarcopenia, commonly termed rheumatoid cachexia (RC). We characterized alterations to muscle structure and various pro-inflammatory, catabolic and regenerative markers in an animal model of RC. Antigen induced arthritis (AiA) was performed in 20 male adult rabbits. AiA animals exhibited significantly less weight gain, a markedly elevated serum C-reactive protein (CRP), lighter muscles with shorter cross-sectional diameter and increased myonuclei when compared to controls. Atrogin-1 and MuRF-1 were up-regulated alongside an increase in IL-1β, active NF-κB and a higher ratio of phosphorylated to inactive p38 MAPK. CCL-2 and TNF levels were reduced and IL-6 was unchanged between groups. We observed decreased pSTAT3, unchanged pSTAT1 and Myf5, but increased Pax7, MyoD and myogenin. AiA rabbits had a reduction in myostatin from gastrocnemii and synovium with a congruent decrease in serum myostatin compared to controls. Chronic arthritis induced an RC-like secondary sarcopenia with increased muscle protein breakdown. Elevated IL-1β may trigger proteolysis via elevated NF-κB and p38 MAPK signaling with a compensatory anabolic response suggested by myonuclear expansion, increased Pax7, MyoD and myogenin, reduced pSTAT3 as well as reduced serum, synovial and muscular myostatinThis work was partially supported by research grants from the Instituto de Salud Carlos III (PI13/00570, PI15/00340, PI16/00065 and RETICEF RD12/0043/0008), co-funded by Fondo Europeo de Desarrollo Regional (FEDER) and ASPIRE IIR grant from Pfizer.Nature Publishing GroupDepartamento de MedicinaFacultad de MedicinaInstituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)20172017-07-24research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/680224https://dx.doi.org/10.1038/s41598-017-06581-6reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6802242026-06-23T12:46:27Z
dc.title.none.fl_str_mv Compensatory anabolic signaling in the sarcopenia of experimental chronic arthritis
title Compensatory anabolic signaling in the sarcopenia of experimental chronic arthritis
spellingShingle Compensatory anabolic signaling in the sarcopenia of experimental chronic arthritis
Little, Robert D.
Arthritis
Sarcopenia
Chronic arthritis
Compensatory anabolic
Medicina
title_short Compensatory anabolic signaling in the sarcopenia of experimental chronic arthritis
title_full Compensatory anabolic signaling in the sarcopenia of experimental chronic arthritis
title_fullStr Compensatory anabolic signaling in the sarcopenia of experimental chronic arthritis
title_full_unstemmed Compensatory anabolic signaling in the sarcopenia of experimental chronic arthritis
title_sort Compensatory anabolic signaling in the sarcopenia of experimental chronic arthritis
dc.creator.none.fl_str_mv Little, Robert D.
Prieto-Potin, Iván
Pérez-Baos, Sandra
Villalvilla, Amanda
Gratal, Paula
Cicuttini, Flavia
Largo, Raquel
Herrero-Beaumont Cuenca, Gabriel
author Little, Robert D.
author_facet Little, Robert D.
Prieto-Potin, Iván
Pérez-Baos, Sandra
Villalvilla, Amanda
Gratal, Paula
Cicuttini, Flavia
Largo, Raquel
Herrero-Beaumont Cuenca, Gabriel
author_role author
author2 Prieto-Potin, Iván
Pérez-Baos, Sandra
Villalvilla, Amanda
Gratal, Paula
Cicuttini, Flavia
Largo, Raquel
Herrero-Beaumont Cuenca, Gabriel
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Medicina
Facultad de Medicina
Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)
dc.subject.none.fl_str_mv Arthritis
Sarcopenia
Chronic arthritis
Compensatory anabolic
Medicina
topic Arthritis
Sarcopenia
Chronic arthritis
Compensatory anabolic
Medicina
description Inflammatory activity in rheumatoid arthritis may alter the regulation of muscle mass leading to a secondary sarcopenia, commonly termed rheumatoid cachexia (RC). We characterized alterations to muscle structure and various pro-inflammatory, catabolic and regenerative markers in an animal model of RC. Antigen induced arthritis (AiA) was performed in 20 male adult rabbits. AiA animals exhibited significantly less weight gain, a markedly elevated serum C-reactive protein (CRP), lighter muscles with shorter cross-sectional diameter and increased myonuclei when compared to controls. Atrogin-1 and MuRF-1 were up-regulated alongside an increase in IL-1β, active NF-κB and a higher ratio of phosphorylated to inactive p38 MAPK. CCL-2 and TNF levels were reduced and IL-6 was unchanged between groups. We observed decreased pSTAT3, unchanged pSTAT1 and Myf5, but increased Pax7, MyoD and myogenin. AiA rabbits had a reduction in myostatin from gastrocnemii and synovium with a congruent decrease in serum myostatin compared to controls. Chronic arthritis induced an RC-like secondary sarcopenia with increased muscle protein breakdown. Elevated IL-1β may trigger proteolysis via elevated NF-κB and p38 MAPK signaling with a compensatory anabolic response suggested by myonuclear expansion, increased Pax7, MyoD and myogenin, reduced pSTAT3 as well as reduced serum, synovial and muscular myostatin
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-07-24
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/680224
https://dx.doi.org/10.1038/s41598-017-06581-6
url http://hdl.handle.net/10486/680224
https://dx.doi.org/10.1038/s41598-017-06581-6
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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