What Difference Does it Make? Risk-Taking Behavior in Obesity after a Loss is Associated with Decreased Ventromedial Prefrontal Cortex Activity

Altered activity in decision-making neural circuitry may underlie the maladaptive food choices found in obesity. Here, we aimed to identify the brain regions purportedly underpinning risk-taking behavior in individuals with obesity. Twenty-three adult women with obesity and twenty-three healthy weig...

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Autores: Steward, Trevor|||0000-0003-3116-8175, Juaneda-Seguí, Asier, Mestre-Bach, Gemma|||0000-0001-5345-0484, Martínez-Zalacaín, Ignacio|||0000-0002-4036-0284, Vilarrasa, Nuria|||0000-0003-3188-1990, Jiménez Murcia, Susana|||0000-0002-3596-8033, Fernández-Formoso, Jose A., Veciana de las Heras, Misericordia|||0000-0002-1878-8663, Custal, Nuria, Virgili, Nuria, Lopez-Urdiales, Rafael, García Ruiz de Gordejuela, Amador|||0000-0002-0485-8536, Menchón Magriñá, José Manuel|||0000-0002-6231-6524, Soriano-Mas, Carles|||0000-0003-4574-6597, Fernández Aranda, Fernando|||0000-0002-2968-9898
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:253352
Acceso en línea:https://ddd.uab.cat/record/253352
https://dx.doi.org/urn:doi:10.3390/jcm8101551
Access Level:acceso abierto
Palabra clave:Obesity
Fmri
Risk
Reward
Sensation seeking
Impulsivity
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spelling What Difference Does it Make? Risk-Taking Behavior in Obesity after a Loss is Associated with Decreased Ventromedial Prefrontal Cortex ActivitySteward, Trevor|||0000-0003-3116-8175Juaneda-Seguí, AsierMestre-Bach, Gemma|||0000-0001-5345-0484Martínez-Zalacaín, Ignacio|||0000-0002-4036-0284Vilarrasa, Nuria|||0000-0003-3188-1990Jiménez Murcia, Susana|||0000-0002-3596-8033Fernández-Formoso, Jose A.Veciana de las Heras, Misericordia|||0000-0002-1878-8663Custal, NuriaVirgili, NuriaLopez-Urdiales, RafaelGarcía Ruiz de Gordejuela, Amador|||0000-0002-0485-8536Menchón Magriñá, José Manuel|||0000-0002-6231-6524Soriano-Mas, Carles|||0000-0003-4574-6597Fernández Aranda, Fernando|||0000-0002-2968-9898ObesityFmriRiskRewardSensation seekingImpulsivityAltered activity in decision-making neural circuitry may underlie the maladaptive food choices found in obesity. Here, we aimed to identify the brain regions purportedly underpinning risk-taking behavior in individuals with obesity. Twenty-three adult women with obesity and twenty-three healthy weight controls completed the Risky Gains Task during functional magnetic resonance imaging (fMRI). This task allows participants to choose between a safe option for a small, guaranteed monetary reward and risky options with larger rewards. fMRI analyses comparing losing trials to winning trials found that participants with obesity presented decreased activity in the left anterior insula in comparison to controls (p < 0.05, AlphaSim corrected). Moreover, left insula activation during losses vs. wins was negatively correlated with UPPS-P questionnaire sensation seeking scores. During safe vs. risky trials following a loss, the control group exhibited increased activation in the ventromedial prefrontal cortex (vmPFC) (p < 0.05, AlphaSim corrected) in comparison to the OB group. Moreover, vmPFC response in the obesity group during post-loss trials was negatively correlated with risky choices on the task overall. As a whole, our findings support that diminished tuning of the insula towards interoceptive signals may lead to a lack of input to the vmPFC when weighing the costs and benefits of risky choices. 22019-01-0120192019-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/253352https://dx.doi.org/urn:doi:10.3390/jcm8101551reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2533522026-06-06T12:50:31Z
dc.title.none.fl_str_mv What Difference Does it Make? Risk-Taking Behavior in Obesity after a Loss is Associated with Decreased Ventromedial Prefrontal Cortex Activity
title What Difference Does it Make? Risk-Taking Behavior in Obesity after a Loss is Associated with Decreased Ventromedial Prefrontal Cortex Activity
spellingShingle What Difference Does it Make? Risk-Taking Behavior in Obesity after a Loss is Associated with Decreased Ventromedial Prefrontal Cortex Activity
Steward, Trevor|||0000-0003-3116-8175
Obesity
Fmri
Risk
Reward
Sensation seeking
Impulsivity
title_short What Difference Does it Make? Risk-Taking Behavior in Obesity after a Loss is Associated with Decreased Ventromedial Prefrontal Cortex Activity
title_full What Difference Does it Make? Risk-Taking Behavior in Obesity after a Loss is Associated with Decreased Ventromedial Prefrontal Cortex Activity
title_fullStr What Difference Does it Make? Risk-Taking Behavior in Obesity after a Loss is Associated with Decreased Ventromedial Prefrontal Cortex Activity
title_full_unstemmed What Difference Does it Make? Risk-Taking Behavior in Obesity after a Loss is Associated with Decreased Ventromedial Prefrontal Cortex Activity
title_sort What Difference Does it Make? Risk-Taking Behavior in Obesity after a Loss is Associated with Decreased Ventromedial Prefrontal Cortex Activity
dc.creator.none.fl_str_mv Steward, Trevor|||0000-0003-3116-8175
Juaneda-Seguí, Asier
Mestre-Bach, Gemma|||0000-0001-5345-0484
Martínez-Zalacaín, Ignacio|||0000-0002-4036-0284
Vilarrasa, Nuria|||0000-0003-3188-1990
Jiménez Murcia, Susana|||0000-0002-3596-8033
Fernández-Formoso, Jose A.
Veciana de las Heras, Misericordia|||0000-0002-1878-8663
Custal, Nuria
Virgili, Nuria
Lopez-Urdiales, Rafael
García Ruiz de Gordejuela, Amador|||0000-0002-0485-8536
Menchón Magriñá, José Manuel|||0000-0002-6231-6524
Soriano-Mas, Carles|||0000-0003-4574-6597
Fernández Aranda, Fernando|||0000-0002-2968-9898
author Steward, Trevor|||0000-0003-3116-8175
author_facet Steward, Trevor|||0000-0003-3116-8175
Juaneda-Seguí, Asier
Mestre-Bach, Gemma|||0000-0001-5345-0484
Martínez-Zalacaín, Ignacio|||0000-0002-4036-0284
Vilarrasa, Nuria|||0000-0003-3188-1990
Jiménez Murcia, Susana|||0000-0002-3596-8033
Fernández-Formoso, Jose A.
Veciana de las Heras, Misericordia|||0000-0002-1878-8663
Custal, Nuria
Virgili, Nuria
Lopez-Urdiales, Rafael
García Ruiz de Gordejuela, Amador|||0000-0002-0485-8536
Menchón Magriñá, José Manuel|||0000-0002-6231-6524
Soriano-Mas, Carles|||0000-0003-4574-6597
Fernández Aranda, Fernando|||0000-0002-2968-9898
author_role author
author2 Juaneda-Seguí, Asier
Mestre-Bach, Gemma|||0000-0001-5345-0484
Martínez-Zalacaín, Ignacio|||0000-0002-4036-0284
Vilarrasa, Nuria|||0000-0003-3188-1990
Jiménez Murcia, Susana|||0000-0002-3596-8033
Fernández-Formoso, Jose A.
Veciana de las Heras, Misericordia|||0000-0002-1878-8663
Custal, Nuria
Virgili, Nuria
Lopez-Urdiales, Rafael
García Ruiz de Gordejuela, Amador|||0000-0002-0485-8536
Menchón Magriñá, José Manuel|||0000-0002-6231-6524
Soriano-Mas, Carles|||0000-0003-4574-6597
Fernández Aranda, Fernando|||0000-0002-2968-9898
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Obesity
Fmri
Risk
Reward
Sensation seeking
Impulsivity
topic Obesity
Fmri
Risk
Reward
Sensation seeking
Impulsivity
description Altered activity in decision-making neural circuitry may underlie the maladaptive food choices found in obesity. Here, we aimed to identify the brain regions purportedly underpinning risk-taking behavior in individuals with obesity. Twenty-three adult women with obesity and twenty-three healthy weight controls completed the Risky Gains Task during functional magnetic resonance imaging (fMRI). This task allows participants to choose between a safe option for a small, guaranteed monetary reward and risky options with larger rewards. fMRI analyses comparing losing trials to winning trials found that participants with obesity presented decreased activity in the left anterior insula in comparison to controls (p < 0.05, AlphaSim corrected). Moreover, left insula activation during losses vs. wins was negatively correlated with UPPS-P questionnaire sensation seeking scores. During safe vs. risky trials following a loss, the control group exhibited increased activation in the ventromedial prefrontal cortex (vmPFC) (p < 0.05, AlphaSim corrected) in comparison to the OB group. Moreover, vmPFC response in the obesity group during post-loss trials was negatively correlated with risky choices on the task overall. As a whole, our findings support that diminished tuning of the insula towards interoceptive signals may lead to a lack of input to the vmPFC when weighing the costs and benefits of risky choices.
publishDate 2019
dc.date.none.fl_str_mv 2
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/253352
https://dx.doi.org/urn:doi:10.3390/jcm8101551
url https://ddd.uab.cat/record/253352
https://dx.doi.org/urn:doi:10.3390/jcm8101551
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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repository.mail.fl_str_mv
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