Increased prevalence of pathogenic bacteria in the gut microbiota of infants at risk of developing celiac disease: The PROFICEL study

8 páginas, 1 figura, 2 tablas

Detalles Bibliográficos
Autores: Olivares, Marta, Benítez-Páez, Alfonso, Palma, Giada de, Capilla, Amalia, Nova, Esther, Castillejo, Gemma, Varea, Vicente, Marcos, Ascensión, Garrote, José Antonio, Polanco, Isabel, Donat, Ester, Ribes-Koninckx, Carmen, Calvo, Carmen, Ortigosa, Luis, Palau Martínez, Francesc, Sanz Herranz, Yolanda
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/180955
Acceso en línea:http://hdl.handle.net/10261/180955
Access Level:acceso abierto
Palabra clave:HLA genotype
PCR
Celiac disease
Gut microbiota
Pathogenic bacteria
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spelling Increased prevalence of pathogenic bacteria in the gut microbiota of infants at risk of developing celiac disease: The PROFICEL studyOlivares, MartaBenítez-Páez, AlfonsoPalma, Giada deCapilla, AmaliaNova, EstherCastillejo, GemmaVarea, VicenteMarcos, AscensiónGarrote, José AntonioPolanco, IsabelDonat, EsterRibes-Koninckx, CarmenCalvo, CarmenOrtigosa, LuisPalau Martínez, FrancescSanz Herranz, YolandaHLA genotypePCRCeliac diseaseGut microbiotaPathogenic bacteria8 páginas, 1 figura, 2 tablasCeliac disease (CD) is an immune-mediated enteropathy involving genetic and environmental factors, whose interaction influences disease risk. The intestinal microbiota, including viruses and bacteria, could play a role in the pathological process leading to gluten intolerance. In this study, we investigated the prevalence of pathogens in the intestinal microbiota of infants at familial risk of developing CD. We included 127 full-term newborns with at least one first-degree relative with CD. Infants were classified according to milk-feeding practice (breastfeeding or formula feeding) and HLA-DQ genotype (low, intermediate or high genetic risk). The prevalence of pathogenic bacteria and viruses was assessed in the faeces of the infants at 7 days, 1 month and 4 months of age. The prevalence of Clostridium perfringens was higher in formula-fed infants than in breast-fed over the study period, and that of C. difficile at 4 months. Among breastfed infants, a higher prevalence of enterotoxigenic E. coli (ETEC) was found in infants with the highest genetic risk compared either to those with a low or intermediate risk. Among formula-fed infants, a higher prevalence of ETEC was also found in infants with a high genetic risk compared to those of intermediate risk. Our results show that specific factors, such as formula feeding and the HLA-DQ2 genotype, previously linked to a higher risk of developing CD, influence the presence of pathogenic bacteria differently in the intestinal microbiota in early life. Further studies are warranted to establish whether these associations are related to CD onset later in life.This work was supported by grants AGL2011-25169, AGL2014-52101-P and AGL2007-66126-C03-03/ALI (YS and FP) from the Spanish Ministry of Economy and Competitiveness (MINECO). The scholarship to MO from CSIC (JAEpre) and the contract to ABP from the European Union's Seventh Framework Program under the grant agreement no 613979 (MyNewGut) are also fully acknowledged.Peer reviewedTaylor & FrancisLandes BioscienceMinisterio de Economía y Competitividad (España)European Research CouncilConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201920192018info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/180955reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2011-25169info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2014-52101-Pinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2007-66126-C03-03info:eu-repo/grantAgreement/EC/FP7/613979http://dx.doi.org/10.1080/19490976.2018.1451276Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1809552026-05-22T06:33:51Z
dc.title.none.fl_str_mv Increased prevalence of pathogenic bacteria in the gut microbiota of infants at risk of developing celiac disease: The PROFICEL study
title Increased prevalence of pathogenic bacteria in the gut microbiota of infants at risk of developing celiac disease: The PROFICEL study
spellingShingle Increased prevalence of pathogenic bacteria in the gut microbiota of infants at risk of developing celiac disease: The PROFICEL study
Olivares, Marta
HLA genotype
PCR
Celiac disease
Gut microbiota
Pathogenic bacteria
title_short Increased prevalence of pathogenic bacteria in the gut microbiota of infants at risk of developing celiac disease: The PROFICEL study
title_full Increased prevalence of pathogenic bacteria in the gut microbiota of infants at risk of developing celiac disease: The PROFICEL study
title_fullStr Increased prevalence of pathogenic bacteria in the gut microbiota of infants at risk of developing celiac disease: The PROFICEL study
title_full_unstemmed Increased prevalence of pathogenic bacteria in the gut microbiota of infants at risk of developing celiac disease: The PROFICEL study
title_sort Increased prevalence of pathogenic bacteria in the gut microbiota of infants at risk of developing celiac disease: The PROFICEL study
dc.creator.none.fl_str_mv Olivares, Marta
Benítez-Páez, Alfonso
Palma, Giada de
Capilla, Amalia
Nova, Esther
Castillejo, Gemma
Varea, Vicente
Marcos, Ascensión
Garrote, José Antonio
Polanco, Isabel
Donat, Ester
Ribes-Koninckx, Carmen
Calvo, Carmen
Ortigosa, Luis
Palau Martínez, Francesc
Sanz Herranz, Yolanda
author Olivares, Marta
author_facet Olivares, Marta
Benítez-Páez, Alfonso
Palma, Giada de
Capilla, Amalia
Nova, Esther
Castillejo, Gemma
Varea, Vicente
Marcos, Ascensión
Garrote, José Antonio
Polanco, Isabel
Donat, Ester
Ribes-Koninckx, Carmen
Calvo, Carmen
Ortigosa, Luis
Palau Martínez, Francesc
Sanz Herranz, Yolanda
author_role author
author2 Benítez-Páez, Alfonso
Palma, Giada de
Capilla, Amalia
Nova, Esther
Castillejo, Gemma
Varea, Vicente
Marcos, Ascensión
Garrote, José Antonio
Polanco, Isabel
Donat, Ester
Ribes-Koninckx, Carmen
Calvo, Carmen
Ortigosa, Luis
Palau Martínez, Francesc
Sanz Herranz, Yolanda
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
European Research Council
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv HLA genotype
PCR
Celiac disease
Gut microbiota
Pathogenic bacteria
topic HLA genotype
PCR
Celiac disease
Gut microbiota
Pathogenic bacteria
description 8 páginas, 1 figura, 2 tablas
publishDate 2018
dc.date.none.fl_str_mv 2018
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/180955
url http://hdl.handle.net/10261/180955
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2011-25169
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2014-52101-P
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2007-66126-C03-03
info:eu-repo/grantAgreement/EC/FP7/613979
http://dx.doi.org/10.1080/19490976.2018.1451276
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Taylor & Francis
Landes Bioscience
publisher.none.fl_str_mv Taylor & Francis
Landes Bioscience
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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