Cardiac troponin and COVID-19 severity: Results from BIOCOVID study.
BACKGROUND: Myocardial injury is a common finding in COVID-19 strongly associated with severity. We analysed the prevalence and prognostic utility of myocardial injury, characterized by elevated cardiac troponin, in a large population of COVID-19 patients, and further evaluated separately the role o...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Fundació Sant Joan de Déu |
| Repositorio: | r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu |
| OAI Identifier: | oai:fsjd.fundanetsuite.com:p19241 |
| Acceso en línea: | https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19241 |
| Access Level: | acceso abierto |
| Palabra clave: | COVID-19 SARS-CoV-2 cardiac troponin I cardiac troponin T myocardial injury prognosis |
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Cardiac troponin and COVID-19 severity: Results from BIOCOVID study.de Guadiana-Romualdo LGMorell-García DDRodríguez-Fraga OMorales-Indiano CMaría Lourdes Padilla Jiménez AGutiérrez Revilla JIUrrechaga EÁlamo JMHernando Holgado AMDel Carmen Lorenzo Lozano MSánchez Fdez-Pacheco Sde la Hera Cagigal PJuncos Tobarra MÁVílchez JAVírseda Chamorro I 1stGutiérrez Garcia IPastor Murcia YSahuquillo Frías LAltimira Queral LNuez Zaragoza Ede León JARRuiz Ripa ASalas Gómez-Pablos PCebreiros López IFernández Uriarte ALarruzea ÁLuisa López Yepes MSancho Rodríguez NConsuelo Zamorano Andrés MPedregosa Díaz JAcevedo Alcaraz CLuis Blázquez Manzanera APérez Sanmartín SDel Carmen Baamonde Calzada MVera MValera Nuñez ECanalda Campás MGarcía Muñoz SMiquel Bauça Rossello JVicente Gutiérrez LJiménez Añón LPérez Martínez APons Castillo AGonzález Tamayo RFérriz Vivancos JJosé Alcaide Martín Mde Brito Fernández VFDAguadero VGloria García Arévalo MArnaldos Carrillo MGonzález Morales MNúñez Gárate MRuiz Iruela CEsteban Torrella PVila Pérez MManuel Egea-Caparrós JSáenz LGalán Ortega AConsuegra-Sánchez LCOVID-19SARS-CoV-2cardiac troponin Icardiac troponin Tmyocardial injuryprognosisBACKGROUND: Myocardial injury is a common finding in COVID-19 strongly associated with severity. We analysed the prevalence and prognostic utility of myocardial injury, characterized by elevated cardiac troponin, in a large population of COVID-19 patients, and further evaluated separately the role of troponin T and I. METHODS: This is a multicentre, retrospective observational study enrolling patients with laboratory-confirmed COVID-19 who were hospitalized in 32 Spanish hospitals. Elevated troponin levels were defined as values above the sex-specific 99th percentile upper reference limit, as recommended by international guidelines. Thirty-day mortality was defined as endpoint. RESULTS: A total of 1280 COVID-19 patients were included in this study, of whom 187 (14.6%) died during the hospitalization. Using a nonspecific sex cut-off, elevated troponin levels were found in 344 patients (26.9%), increasing to 384 (30.0%) when a sex-specific cut-off was used. This prevalence was significantly higher (42.9% vs 21.9%; P < .001) in patients in whom troponin T was measured in comparison with troponin I. Sex-specific elevated troponin levels were significantly associated with 30-day mortality, with adjusted odds ratios (ORs) of 3.00 for total population, 3.20 for cardiac troponin T and 3.69 for cardiac troponin I. CONCLUSION: In this multicentre study, myocardial injury was a common finding in COVID-19 patients. Its prevalence increased when a sex-specific cut-off and cardiac troponin T were used. Elevated troponin was an independent predictor of 30-day mortality, irrespective of cardiac troponin assay and cut-offs to detect myocardial injury. Hence, the early measurement of cardiac troponin may be useful for risk stratification in COVID-19.WILEY2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19241EUROPEAN JOURNAL OF CLINICAL INVESTIGATIONISSN: 00142972ISSNe: 13652362reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p192412026-05-27T12:37:41Z |
| dc.title.none.fl_str_mv |
Cardiac troponin and COVID-19 severity: Results from BIOCOVID study. |
| title |
Cardiac troponin and COVID-19 severity: Results from BIOCOVID study. |
| spellingShingle |
Cardiac troponin and COVID-19 severity: Results from BIOCOVID study. de Guadiana-Romualdo LG COVID-19 SARS-CoV-2 cardiac troponin I cardiac troponin T myocardial injury prognosis |
| title_short |
Cardiac troponin and COVID-19 severity: Results from BIOCOVID study. |
| title_full |
Cardiac troponin and COVID-19 severity: Results from BIOCOVID study. |
| title_fullStr |
Cardiac troponin and COVID-19 severity: Results from BIOCOVID study. |
| title_full_unstemmed |
Cardiac troponin and COVID-19 severity: Results from BIOCOVID study. |
| title_sort |
Cardiac troponin and COVID-19 severity: Results from BIOCOVID study. |
| dc.creator.none.fl_str_mv |
de Guadiana-Romualdo LG Morell-García DD Rodríguez-Fraga O Morales-Indiano C María Lourdes Padilla Jiménez A Gutiérrez Revilla JI Urrechaga E Álamo JM Hernando Holgado AM Del Carmen Lorenzo Lozano M Sánchez Fdez-Pacheco S de la Hera Cagigal P Juncos Tobarra MÁ Vílchez JA Vírseda Chamorro I 1st Gutiérrez Garcia I Pastor Murcia Y Sahuquillo Frías L Altimira Queral L Nuez Zaragoza E de León JAR Ruiz Ripa A Salas Gómez-Pablos P Cebreiros López I Fernández Uriarte A Larruzea Á Luisa López Yepes M Sancho Rodríguez N Consuelo Zamorano Andrés M Pedregosa Díaz J Acevedo Alcaraz C Luis Blázquez Manzanera A Pérez Sanmartín S Del Carmen Baamonde Calzada M Vera M Valera Nuñez E Canalda Campás M García Muñoz S Miquel Bauça Rossello J Vicente Gutiérrez L Jiménez Añón L Pérez Martínez A Pons Castillo A González Tamayo R Férriz Vivancos J José Alcaide Martín M de Brito Fernández VFD Aguadero V Gloria García Arévalo M Arnaldos Carrillo M González Morales M Núñez Gárate M Ruiz Iruela C Esteban Torrella P Vila Pérez M Manuel Egea-Caparrós J Sáenz L Galán Ortega A Consuegra-Sánchez L |
| author |
de Guadiana-Romualdo LG |
| author_facet |
de Guadiana-Romualdo LG Morell-García DD Rodríguez-Fraga O Morales-Indiano C María Lourdes Padilla Jiménez A Gutiérrez Revilla JI Urrechaga E Álamo JM Hernando Holgado AM Del Carmen Lorenzo Lozano M Sánchez Fdez-Pacheco S de la Hera Cagigal P Juncos Tobarra MÁ Vílchez JA Vírseda Chamorro I 1st Gutiérrez Garcia I Pastor Murcia Y Sahuquillo Frías L Altimira Queral L Nuez Zaragoza E de León JAR Ruiz Ripa A Salas Gómez-Pablos P Cebreiros López I Fernández Uriarte A Larruzea Á Luisa López Yepes M Sancho Rodríguez N Consuelo Zamorano Andrés M Pedregosa Díaz J Acevedo Alcaraz C Luis Blázquez Manzanera A Pérez Sanmartín S Del Carmen Baamonde Calzada M Vera M Valera Nuñez E Canalda Campás M García Muñoz S Miquel Bauça Rossello J Vicente Gutiérrez L Jiménez Añón L Pérez Martínez A Pons Castillo A González Tamayo R Férriz Vivancos J José Alcaide Martín M de Brito Fernández VFD Aguadero V Gloria García Arévalo M Arnaldos Carrillo M González Morales M Núñez Gárate M Ruiz Iruela C Esteban Torrella P Vila Pérez M Manuel Egea-Caparrós J Sáenz L Galán Ortega A Consuegra-Sánchez L |
| author_role |
author |
| author2 |
Morell-García DD Rodríguez-Fraga O Morales-Indiano C María Lourdes Padilla Jiménez A Gutiérrez Revilla JI Urrechaga E Álamo JM Hernando Holgado AM Del Carmen Lorenzo Lozano M Sánchez Fdez-Pacheco S de la Hera Cagigal P Juncos Tobarra MÁ Vílchez JA Vírseda Chamorro I 1st Gutiérrez Garcia I Pastor Murcia Y Sahuquillo Frías L Altimira Queral L Nuez Zaragoza E de León JAR Ruiz Ripa A Salas Gómez-Pablos P Cebreiros López I Fernández Uriarte A Larruzea Á Luisa López Yepes M Sancho Rodríguez N Consuelo Zamorano Andrés M Pedregosa Díaz J Acevedo Alcaraz C Luis Blázquez Manzanera A Pérez Sanmartín S Del Carmen Baamonde Calzada M Vera M Valera Nuñez E Canalda Campás M García Muñoz S Miquel Bauça Rossello J Vicente Gutiérrez L Jiménez Añón L Pérez Martínez A Pons Castillo A González Tamayo R Férriz Vivancos J José Alcaide Martín M de Brito Fernández VFD Aguadero V Gloria García Arévalo M Arnaldos Carrillo M González Morales M Núñez Gárate M Ruiz Iruela C Esteban Torrella P Vila Pérez M Manuel Egea-Caparrós J Sáenz L Galán Ortega A Consuegra-Sánchez L |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
COVID-19 SARS-CoV-2 cardiac troponin I cardiac troponin T myocardial injury prognosis |
| topic |
COVID-19 SARS-CoV-2 cardiac troponin I cardiac troponin T myocardial injury prognosis |
| description |
BACKGROUND: Myocardial injury is a common finding in COVID-19 strongly associated with severity. We analysed the prevalence and prognostic utility of myocardial injury, characterized by elevated cardiac troponin, in a large population of COVID-19 patients, and further evaluated separately the role of troponin T and I. METHODS: This is a multicentre, retrospective observational study enrolling patients with laboratory-confirmed COVID-19 who were hospitalized in 32 Spanish hospitals. Elevated troponin levels were defined as values above the sex-specific 99th percentile upper reference limit, as recommended by international guidelines. Thirty-day mortality was defined as endpoint. RESULTS: A total of 1280 COVID-19 patients were included in this study, of whom 187 (14.6%) died during the hospitalization. Using a nonspecific sex cut-off, elevated troponin levels were found in 344 patients (26.9%), increasing to 384 (30.0%) when a sex-specific cut-off was used. This prevalence was significantly higher (42.9% vs 21.9%; P < .001) in patients in whom troponin T was measured in comparison with troponin I. Sex-specific elevated troponin levels were significantly associated with 30-day mortality, with adjusted odds ratios (ORs) of 3.00 for total population, 3.20 for cardiac troponin T and 3.69 for cardiac troponin I. CONCLUSION: In this multicentre study, myocardial injury was a common finding in COVID-19 patients. Its prevalence increased when a sex-specific cut-off and cardiac troponin T were used. Elevated troponin was an independent predictor of 30-day mortality, irrespective of cardiac troponin assay and cut-offs to detect myocardial injury. Hence, the early measurement of cardiac troponin may be useful for risk stratification in COVID-19. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19241 |
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https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19241 |
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Inglés |
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Inglés |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
| dc.publisher.none.fl_str_mv |
WILEY |
| publisher.none.fl_str_mv |
WILEY |
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EUROPEAN JOURNAL OF CLINICAL INVESTIGATION ISSN: 00142972 ISSNe: 13652362 reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu instname:Fundació Sant Joan de Déu |
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Fundació Sant Joan de Déu |
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r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu |
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r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu |
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15.812429 |