Usefulness of the COVID-GRAM and CURB-65 scores for predicting severity in patients with COVID-19

Aim: The aim of this study was to determine the usefulness of COVID-GRAM and CURB-65 scores as predictors of the severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Caucasian patients. Methods: This was a retrospective observational study including all adults with S...

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Autores: Armiñanzas Castillo, Carlos|||0000-0001-9009-7552, Arnáiz de las Revillas Almajano, Francisco|||0000-0002-0611-6309, Gutiérrez Cuadra, Manuel, Arnaiz García, Ana María, Fernández Sampedro, Marta, González Rico, Claudia, Ferrer Pargada, Diego, Mora Cuesta, Víctor Manuel|||0000-0002-8161-0462, Suberviola, Borja, Latorre, Maite, Calvo, Jorge, Olmos Martínez, José Manuel, Cifrián Martínez, José Manuel, Fariñas Álvarez, María del Carmen
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/24459
Acceso en línea:http://hdl.handle.net/10902/24459
Access Level:acceso abierto
Palabra clave:Coronavirus
COVID
CURB-65
COVID-GRAM
Severity score
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spelling Usefulness of the COVID-GRAM and CURB-65 scores for predicting severity in patients with COVID-19Armiñanzas Castillo, Carlos|||0000-0001-9009-7552Arnáiz de las Revillas Almajano, Francisco|||0000-0002-0611-6309Gutiérrez Cuadra, ManuelArnaiz García, Ana MaríaFernández Sampedro, MartaGonzález Rico, ClaudiaFerrer Pargada, DiegoMora Cuesta, Víctor Manuel|||0000-0002-8161-0462Suberviola, BorjaLatorre, MaiteCalvo, JorgeOlmos Martínez, José ManuelCifrián Martínez, José ManuelFariñas Álvarez, María del CarmenCoronavirusCOVIDCURB-65COVID-GRAMSeverity scoreAim: The aim of this study was to determine the usefulness of COVID-GRAM and CURB-65 scores as predictors of the severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Caucasian patients. Methods: This was a retrospective observational study including all adults with SARS-CoV-2 infection admitted to Hospital Universitario Marqués de Valdecilla from February to May 2020. Patients were stratified according to COVID-GRAM and CURB-65 scores as being at low-medium or high risk of critical illness. Univariate analysis, multivariate logistic regression models, receiver operating characteristic curve, and area under the curve (AUC) were calculated. Results: A total of 523 patients were included (51.8% male, 48.2% female; mean age 65.63 years (standard deviation 17.89 years)), of whom 110 (21%) presented a critical illness (intensive care unit admission 10.3%, 30-day mortality 13.8%). According to the COVID-GRAM score, 122 (23.33%) patients were classified as high risk; 197 (37.7%) presented a CURB-65 score ?2. A significantly greater proportion of patients with critical illness had a high COVID-GRAM score (64.5% vs 30.5%; P < 0.001). The COVID-GRAM score emerged as an independent predictor of critical illness (odds ratio 9.40, 95% confidence interval 5.51-16.04; P < 0.001), with an AUC of 0.779. A high COVID-GRAM score showed an AUC of 0.88 for the prediction of 30-day mortality, while a CURB-65 ?2 showed an AUC of 0.83. Conclusions: The COVID-GRAM score may be a useful tool for evaluating the risk of critical illness in Caucasian patients with SARS-CoV-2 infection. The CURB-65 score could be considered as an alternative.ElsevierUniversidad de Cantabria20212021-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttp://hdl.handle.net/10902/24459Int J Infect Dis . 2021 Jul;108:282-288reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/244592026-06-02T12:39:31Z
dc.title.none.fl_str_mv Usefulness of the COVID-GRAM and CURB-65 scores for predicting severity in patients with COVID-19
title Usefulness of the COVID-GRAM and CURB-65 scores for predicting severity in patients with COVID-19
spellingShingle Usefulness of the COVID-GRAM and CURB-65 scores for predicting severity in patients with COVID-19
Armiñanzas Castillo, Carlos|||0000-0001-9009-7552
Coronavirus
COVID
CURB-65
COVID-GRAM
Severity score
title_short Usefulness of the COVID-GRAM and CURB-65 scores for predicting severity in patients with COVID-19
title_full Usefulness of the COVID-GRAM and CURB-65 scores for predicting severity in patients with COVID-19
title_fullStr Usefulness of the COVID-GRAM and CURB-65 scores for predicting severity in patients with COVID-19
title_full_unstemmed Usefulness of the COVID-GRAM and CURB-65 scores for predicting severity in patients with COVID-19
title_sort Usefulness of the COVID-GRAM and CURB-65 scores for predicting severity in patients with COVID-19
dc.creator.none.fl_str_mv Armiñanzas Castillo, Carlos|||0000-0001-9009-7552
Arnáiz de las Revillas Almajano, Francisco|||0000-0002-0611-6309
Gutiérrez Cuadra, Manuel
Arnaiz García, Ana María
Fernández Sampedro, Marta
González Rico, Claudia
Ferrer Pargada, Diego
Mora Cuesta, Víctor Manuel|||0000-0002-8161-0462
Suberviola, Borja
Latorre, Maite
Calvo, Jorge
Olmos Martínez, José Manuel
Cifrián Martínez, José Manuel
Fariñas Álvarez, María del Carmen
author Armiñanzas Castillo, Carlos|||0000-0001-9009-7552
author_facet Armiñanzas Castillo, Carlos|||0000-0001-9009-7552
Arnáiz de las Revillas Almajano, Francisco|||0000-0002-0611-6309
Gutiérrez Cuadra, Manuel
Arnaiz García, Ana María
Fernández Sampedro, Marta
González Rico, Claudia
Ferrer Pargada, Diego
Mora Cuesta, Víctor Manuel|||0000-0002-8161-0462
Suberviola, Borja
Latorre, Maite
Calvo, Jorge
Olmos Martínez, José Manuel
Cifrián Martínez, José Manuel
Fariñas Álvarez, María del Carmen
author_role author
author2 Arnáiz de las Revillas Almajano, Francisco|||0000-0002-0611-6309
Gutiérrez Cuadra, Manuel
Arnaiz García, Ana María
Fernández Sampedro, Marta
González Rico, Claudia
Ferrer Pargada, Diego
Mora Cuesta, Víctor Manuel|||0000-0002-8161-0462
Suberviola, Borja
Latorre, Maite
Calvo, Jorge
Olmos Martínez, José Manuel
Cifrián Martínez, José Manuel
Fariñas Álvarez, María del Carmen
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
dc.subject.none.fl_str_mv Coronavirus
COVID
CURB-65
COVID-GRAM
Severity score
topic Coronavirus
COVID
CURB-65
COVID-GRAM
Severity score
description Aim: The aim of this study was to determine the usefulness of COVID-GRAM and CURB-65 scores as predictors of the severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Caucasian patients. Methods: This was a retrospective observational study including all adults with SARS-CoV-2 infection admitted to Hospital Universitario Marqués de Valdecilla from February to May 2020. Patients were stratified according to COVID-GRAM and CURB-65 scores as being at low-medium or high risk of critical illness. Univariate analysis, multivariate logistic regression models, receiver operating characteristic curve, and area under the curve (AUC) were calculated. Results: A total of 523 patients were included (51.8% male, 48.2% female; mean age 65.63 years (standard deviation 17.89 years)), of whom 110 (21%) presented a critical illness (intensive care unit admission 10.3%, 30-day mortality 13.8%). According to the COVID-GRAM score, 122 (23.33%) patients were classified as high risk; 197 (37.7%) presented a CURB-65 score ?2. A significantly greater proportion of patients with critical illness had a high COVID-GRAM score (64.5% vs 30.5%; P < 0.001). The COVID-GRAM score emerged as an independent predictor of critical illness (odds ratio 9.40, 95% confidence interval 5.51-16.04; P < 0.001), with an AUC of 0.779. A high COVID-GRAM score showed an AUC of 0.88 for the prediction of 30-day mortality, while a CURB-65 ?2 showed an AUC of 0.83. Conclusions: The COVID-GRAM score may be a useful tool for evaluating the risk of critical illness in Caucasian patients with SARS-CoV-2 infection. The CURB-65 score could be considered as an alternative.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10902/24459
url http://hdl.handle.net/10902/24459
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Int J Infect Dis . 2021 Jul;108:282-288
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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