Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain

Background: Several studies have suggested that Helicobacter pylori (H. pylori) infection is a risk factor for colorectal cancer (CRC), while others have not confirmed this hypothesis. This work aimed to assess the relation of CRC with H. pylori seropositivity and with seropositivity to 16 H. pylori...

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Autores: Fernández de Larrea Baz, Nerea, Michel, Angelika, Romero, Beatriz, Pérez Gómez, Beatriz, Moreno Aguado, Víctor, Martín Sánchez, Vicente, Dierssen Sotos, Trinidad, Jiménez Moleón, José Juan, Castilla, Jesús, Tardón, Adonina, Ruiz, Irune, Peiró Pérez, Rosana, Tejada, Antonio, Chirlaque, María Dolores, Butt, Julia A., Olmedo Requena, Rocío, Gómez Acebo, Inés, Linares, Pedro, Boldo, Elena, Castells Garangou, Antoni, Pawlita, Michael, Castaño-Vinyals, Gemma, Kogevinas, Manolis, Sanjosé Llongueras, Silvia de, Pollán, Marina, Campo, Rosa del, Waterboer, Tim, Aragonès Sanz, Núria
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/139819
Acceso en línea:https://hdl.handle.net/2445/139819
Access Level:acceso abierto
Palabra clave:Helicobacteri pilòric
Càncer colorectal
Helicobacter pylori
Colorectal cancer
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spelling Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in SpainFernández de Larrea Baz, NereaMichel, AngelikaRomero, BeatrizPérez Gómez, BeatrizMoreno Aguado, VíctorMartín Sánchez, VicenteDierssen Sotos, TrinidadJiménez Moleón, José JuanCastilla, JesúsTardón, AdoninaRuiz, IrunePeiró Pérez, RosanaTejada, AntonioChirlaque, María DoloresButt, Julia A.Olmedo Requena, RocíoGómez Acebo, InésLinares, PedroBoldo, ElenaCastells Garangou, AntoniPawlita, MichaelCastaño-Vinyals, GemmaKogevinas, ManolisSanjosé Llongueras, Silvia dePollán, MarinaCampo, Rosa delWaterboer, TimAragonès Sanz, NúriaHelicobacteri pilòricCàncer colorectalHelicobacter pyloriColorectal cancerBackground: Several studies have suggested that Helicobacter pylori (H. pylori) infection is a risk factor for colorectal cancer (CRC), while others have not confirmed this hypothesis. This work aimed to assess the relation of CRC with H. pylori seropositivity and with seropositivity to 16 H. pylori proteins, in the MultiCase-Control study, MCC-Spain.Methods: MCC-Spain is a multicase-control study carried out in Spain from 2008 to 2013. In total, 2,140 histologically-confirmed incident CRC cases and 4,098 population-based controls were recruited. Controls were frequency-matched by sex, age, and province. Epidemiological data were collected through a questionnaire fulfilled by face-to-face interviews and a self-administered food-frequency questionnaire. Seroreactivities against 16 H. pylori proteins were determined in 1,488 cases and 2,495 controls using H. pylori multiplex serology. H. pylori seropositivity was defined as positivity to >= 4 proteins. Multivariable logistic regression mixed models were used to estimate odds ratios (OR) and 95% confidence intervals (CI).Results: H. pylori seropositivity was not associated with increased CRC risk (OR = 0.91; 95% CI: 0.71-1.16). Among H. pylori seropositive subjects, seropositivity to Cag delta showed a lower CRC risk, and risk decreased with increasing number of proteins seropositive. Seropositivity to the most recognized virulence factors, CagA and VacA, was not associated with a higher CRC risk. No statistically significant heterogeneity was identified among tumor sites, although inverse relations were stronger for left colon cancer. An interaction with age and sex was found: H. pylori seropositivity was associated with a lower CRC risk in men younger than 65 and with a higher risk in older women.Conclusions: Our results suggest that neither H. pylori seropositivity, nor seropositivity to the virulence factor CagA are associated with a higher CRC risk. A possible effect modification by age and sex was identified.Frontiers Media2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/139819Articles publicats en revistes (Ciències Clíniques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3389/fmicb.2017.00888Frontiers in Microbiology, 2017, vol. 8https://doi.org/10.3389/fmicb.2017.00888cc-by (c) Fernández de Larrea Baz, Nerea et al., 2017http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1398192026-05-27T06:46:51Z
dc.title.none.fl_str_mv Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain
title Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain
spellingShingle Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain
Fernández de Larrea Baz, Nerea
Helicobacteri pilòric
Càncer colorectal
Helicobacter pylori
Colorectal cancer
title_short Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain
title_full Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain
title_fullStr Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain
title_full_unstemmed Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain
title_sort Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain
dc.creator.none.fl_str_mv Fernández de Larrea Baz, Nerea
Michel, Angelika
Romero, Beatriz
Pérez Gómez, Beatriz
Moreno Aguado, Víctor
Martín Sánchez, Vicente
Dierssen Sotos, Trinidad
Jiménez Moleón, José Juan
Castilla, Jesús
Tardón, Adonina
Ruiz, Irune
Peiró Pérez, Rosana
Tejada, Antonio
Chirlaque, María Dolores
Butt, Julia A.
Olmedo Requena, Rocío
Gómez Acebo, Inés
Linares, Pedro
Boldo, Elena
Castells Garangou, Antoni
Pawlita, Michael
Castaño-Vinyals, Gemma
Kogevinas, Manolis
Sanjosé Llongueras, Silvia de
Pollán, Marina
Campo, Rosa del
Waterboer, Tim
Aragonès Sanz, Núria
author Fernández de Larrea Baz, Nerea
author_facet Fernández de Larrea Baz, Nerea
Michel, Angelika
Romero, Beatriz
Pérez Gómez, Beatriz
Moreno Aguado, Víctor
Martín Sánchez, Vicente
Dierssen Sotos, Trinidad
Jiménez Moleón, José Juan
Castilla, Jesús
Tardón, Adonina
Ruiz, Irune
Peiró Pérez, Rosana
Tejada, Antonio
Chirlaque, María Dolores
Butt, Julia A.
Olmedo Requena, Rocío
Gómez Acebo, Inés
Linares, Pedro
Boldo, Elena
Castells Garangou, Antoni
Pawlita, Michael
Castaño-Vinyals, Gemma
Kogevinas, Manolis
Sanjosé Llongueras, Silvia de
Pollán, Marina
Campo, Rosa del
Waterboer, Tim
Aragonès Sanz, Núria
author_role author
author2 Michel, Angelika
Romero, Beatriz
Pérez Gómez, Beatriz
Moreno Aguado, Víctor
Martín Sánchez, Vicente
Dierssen Sotos, Trinidad
Jiménez Moleón, José Juan
Castilla, Jesús
Tardón, Adonina
Ruiz, Irune
Peiró Pérez, Rosana
Tejada, Antonio
Chirlaque, María Dolores
Butt, Julia A.
Olmedo Requena, Rocío
Gómez Acebo, Inés
Linares, Pedro
Boldo, Elena
Castells Garangou, Antoni
Pawlita, Michael
Castaño-Vinyals, Gemma
Kogevinas, Manolis
Sanjosé Llongueras, Silvia de
Pollán, Marina
Campo, Rosa del
Waterboer, Tim
Aragonès Sanz, Núria
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Helicobacteri pilòric
Càncer colorectal
Helicobacter pylori
Colorectal cancer
topic Helicobacteri pilòric
Càncer colorectal
Helicobacter pylori
Colorectal cancer
description Background: Several studies have suggested that Helicobacter pylori (H. pylori) infection is a risk factor for colorectal cancer (CRC), while others have not confirmed this hypothesis. This work aimed to assess the relation of CRC with H. pylori seropositivity and with seropositivity to 16 H. pylori proteins, in the MultiCase-Control study, MCC-Spain.Methods: MCC-Spain is a multicase-control study carried out in Spain from 2008 to 2013. In total, 2,140 histologically-confirmed incident CRC cases and 4,098 population-based controls were recruited. Controls were frequency-matched by sex, age, and province. Epidemiological data were collected through a questionnaire fulfilled by face-to-face interviews and a self-administered food-frequency questionnaire. Seroreactivities against 16 H. pylori proteins were determined in 1,488 cases and 2,495 controls using H. pylori multiplex serology. H. pylori seropositivity was defined as positivity to >= 4 proteins. Multivariable logistic regression mixed models were used to estimate odds ratios (OR) and 95% confidence intervals (CI).Results: H. pylori seropositivity was not associated with increased CRC risk (OR = 0.91; 95% CI: 0.71-1.16). Among H. pylori seropositive subjects, seropositivity to Cag delta showed a lower CRC risk, and risk decreased with increasing number of proteins seropositive. Seropositivity to the most recognized virulence factors, CagA and VacA, was not associated with a higher CRC risk. No statistically significant heterogeneity was identified among tumor sites, although inverse relations were stronger for left colon cancer. An interaction with age and sex was found: H. pylori seropositivity was associated with a lower CRC risk in men younger than 65 and with a higher risk in older women.Conclusions: Our results suggest that neither H. pylori seropositivity, nor seropositivity to the virulence factor CagA are associated with a higher CRC risk. A possible effect modification by age and sex was identified.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/139819
url https://hdl.handle.net/2445/139819
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fmicb.2017.00888
Frontiers in Microbiology, 2017, vol. 8
https://doi.org/10.3389/fmicb.2017.00888
dc.rights.none.fl_str_mv cc-by (c) Fernández de Larrea Baz, Nerea et al., 2017
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Fernández de Larrea Baz, Nerea et al., 2017
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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