Parallelized Ultrasound-Guiding for Enhanced Light Delivery within Scattering Media

The delivery of light over an extended area within a sample forms the basis of biomedical applications that are as relevant as photoacoustic tomography, fluorescence imaging, and phototherapy techniques. However, light scattering limits the ability of these methods to reach deep regions within biolo...

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Detalhes bibliográficos
Autores: Mestre Torà, Blanca, Duocastella, Martí
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2024
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/221136
Acesso em linha:https://hdl.handle.net/2445/221136
Access Level:Acceso aberto
Palavra-chave:Teoria quàntica
Dispersió de la llum
Quantum theory
Light scattering
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spelling Parallelized Ultrasound-Guiding for Enhanced Light Delivery within Scattering MediaMestre Torà, BlancaDuocastella, MartíTeoria quànticaDispersió de la llumQuantum theoryLight scatteringThe delivery of light over an extended area within a sample forms the basis of biomedical applications that are as relevant as photoacoustic tomography, fluorescence imaging, and phototherapy techniques. However, light scattering limits the ability of these methods to reach deep regions within biological tissues. As a result, their operational range remains confined to superficial areas of samples, posing a significant barrier to effective optical treatment and diagnosis. Here, we propose an approach to address this issue and enhance light delivery across an extended region inside scattering samples. Our strategy involves using ultrasound to directly modulate the optical properties of the sample, generating refractive index gradients that act as embedded optical waveguides. By employing two perpendicularly oriented piezoelectric plates, several parallel waveguides can be simultaneously formed within the sample, allowing light to be guided over a wide area (3 × 3 mm2 in current experiments). Supported by Monte Carlo simulations, we demonstrate that ultrasound-light-guiding can enhance the intensity of light delivered inside scattering samples with an optical thickness of 2.5 and 12.5 by up to a factor of 700 and 42%, respectively. As a proof-of-concept, we demonstrated the ability of our approach to irradiate nanoparticles located within a scattering sample at light intensities that are not possible without ultrasound.American Chemical Society2025202520242025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion9 p.application/pdfhttps://hdl.handle.net/2445/221136Articles publicats en revistes (Física Aplicada)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1021/acsphotonics.4c01398ACS Photonics, 2024, vol. 11, num.12, p. 5161-5169https://doi.org/10.1021/acsphotonics.4c01398cc-by (c) Mestre Torà et al., 2024http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2211362026-05-29T05:05:01Z
dc.title.none.fl_str_mv Parallelized Ultrasound-Guiding for Enhanced Light Delivery within Scattering Media
title Parallelized Ultrasound-Guiding for Enhanced Light Delivery within Scattering Media
spellingShingle Parallelized Ultrasound-Guiding for Enhanced Light Delivery within Scattering Media
Mestre Torà, Blanca
Teoria quàntica
Dispersió de la llum
Quantum theory
Light scattering
title_short Parallelized Ultrasound-Guiding for Enhanced Light Delivery within Scattering Media
title_full Parallelized Ultrasound-Guiding for Enhanced Light Delivery within Scattering Media
title_fullStr Parallelized Ultrasound-Guiding for Enhanced Light Delivery within Scattering Media
title_full_unstemmed Parallelized Ultrasound-Guiding for Enhanced Light Delivery within Scattering Media
title_sort Parallelized Ultrasound-Guiding for Enhanced Light Delivery within Scattering Media
dc.creator.none.fl_str_mv Mestre Torà, Blanca
Duocastella, Martí
author Mestre Torà, Blanca
author_facet Mestre Torà, Blanca
Duocastella, Martí
author_role author
author2 Duocastella, Martí
author2_role author
dc.subject.none.fl_str_mv Teoria quàntica
Dispersió de la llum
Quantum theory
Light scattering
topic Teoria quàntica
Dispersió de la llum
Quantum theory
Light scattering
description The delivery of light over an extended area within a sample forms the basis of biomedical applications that are as relevant as photoacoustic tomography, fluorescence imaging, and phototherapy techniques. However, light scattering limits the ability of these methods to reach deep regions within biological tissues. As a result, their operational range remains confined to superficial areas of samples, posing a significant barrier to effective optical treatment and diagnosis. Here, we propose an approach to address this issue and enhance light delivery across an extended region inside scattering samples. Our strategy involves using ultrasound to directly modulate the optical properties of the sample, generating refractive index gradients that act as embedded optical waveguides. By employing two perpendicularly oriented piezoelectric plates, several parallel waveguides can be simultaneously formed within the sample, allowing light to be guided over a wide area (3 × 3 mm2 in current experiments). Supported by Monte Carlo simulations, we demonstrate that ultrasound-light-guiding can enhance the intensity of light delivered inside scattering samples with an optical thickness of 2.5 and 12.5 by up to a factor of 700 and 42%, respectively. As a proof-of-concept, we demonstrated the ability of our approach to irradiate nanoparticles located within a scattering sample at light intensities that are not possible without ultrasound.
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/221136
url https://hdl.handle.net/2445/221136
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1021/acsphotonics.4c01398
ACS Photonics, 2024, vol. 11, num.12, p. 5161-5169
https://doi.org/10.1021/acsphotonics.4c01398
dc.rights.none.fl_str_mv cc-by (c) Mestre Torà et al., 2024
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Mestre Torà et al., 2024
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9 p.
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv Articles publicats en revistes (Física Aplicada)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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