Estradiol meets notch signaling in developing neurons
The transmembrane receptor Notch, a master developmental regulator, controls gliogene- sis, neurogenesis, and neurite development in the nervous system. Estradiol, acting as a hormonal signal or as a neurosteroid, also regulates these developmental processes. Here we review recent evidence indicatin...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2010 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/150171 |
| Acceso en línea: | http://hdl.handle.net/10261/150171 |
| Access Level: | acceso abierto |
| Palabra clave: | Estrogen receptors dendritogenesis hairy and enhancer of split neurogenin 3 G protein-coupled receptor 30 G protein-coupled estrogen receptor |
| Sumario: | The transmembrane receptor Notch, a master developmental regulator, controls gliogene- sis, neurogenesis, and neurite development in the nervous system. Estradiol, acting as a hormonal signal or as a neurosteroid, also regulates these developmental processes. Here we review recent evidence indicating that estradiol and Notch signaling interact in devel- oping hippocampal neurons by a mechanism involving the putative membrane receptor G protein-coupled receptor 30.This interaction is relevant for the control of neuronal differen- tiation, since the downregulation of Notch signaling by estradiol results in the upregulation of neurogenin 3, which in turn promotes dendritogenesis. © 2011 Arevalo, Ruiz-Palmero, Simon-Areces, Acaz-Fonseca, Azcoitia and Garcia-Segura. |
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