Impact of tobacco, alcohol, and marijuana on genome-wide DNA methylation and its relationship with hypertension

Tobacco, alcohol, and marijuana consumption is an important public health problem because of their high use worldwide and their association with the risk of mortality and many health conditions, such as hypertension, which is the commonest risk factor for death throughout the world. A likely pathway...

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Autores: Carreras-Gallo, Natàlia|||0000-0001-8559-2313, Dwaraka, Varun B., Cáceres, Alejandro|||0000-0001-8551-6695, Smith, Ryan|||0000-0002-3880-9740, Mendez, Tavis L., Went, Hannah, González, Juan Ramón|||0000-0003-3267-2146
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:286217
Acceso en línea:https://ddd.uab.cat/record/286217
https://dx.doi.org/urn:doi:10.1080/15592294.2023.2214392
Access Level:acceso abierto
Palabra clave:Tobacco
Alcohol
Marijuana
DNA methylation
Epigenome-wide association study
Hypertension
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spelling Impact of tobacco, alcohol, and marijuana on genome-wide DNA methylation and its relationship with hypertensionCarreras-Gallo, Natàlia|||0000-0001-8559-2313Dwaraka, Varun B.Cáceres, Alejandro|||0000-0001-8551-6695Smith, Ryan|||0000-0002-3880-9740Mendez, Tavis L.Went, HannahGonzález, Juan Ramón|||0000-0003-3267-2146TobaccoAlcoholMarijuanaDNA methylationEpigenome-wide association studyHypertensionTobacco, alcohol, and marijuana consumption is an important public health problem because of their high use worldwide and their association with the risk of mortality and many health conditions, such as hypertension, which is the commonest risk factor for death throughout the world. A likely pathway of action of substance consumption leading to persistent hypertension is DNA methylation. Here, we evaluated the effects of tobacco, alcohol, and marijuana on DNA methylation in the same cohort (N = 3,424). Three epigenome-wide association studies (EWAS) were assessed in whole blood using the InfiniumHumanMethylationEPIC BeadChip. We also evaluated the mediation of the top CpG sites in the association between substance consumption and hypertension. Our analyses showed 2,569 CpG sites differentially methylated by alcohol drinking and 528 by tobacco smoking. We did not find significant associations with marijuana consumption after correcting for multiple comparisons. We found 61 genes overlapping between alcohol and tobacco that were enriched in biological processes involved in the nervous and cardiovascular systems. In the mediation analysis, we found 66 CpG sites that significantly mediated the effect of alcohol consumption on hypertension. The top alcohol-related CpG site (cg06690548, P-value = 5.9·10 -83) mapped to SLC7A11 strongly mediated 70.5% of the effect of alcohol consumption on hypertension (P-value = 0.006). Our findings suggest that DNA methylation should be considered for new targets in hypertension prevention and management, particularly concerning alcohol consumption. Our data also encourage further research into the use of methylation in blood to study the neurological and cardiovascular effects of substance consumption. 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/286217https://dx.doi.org/urn:doi:10.1080/15592294.2023.2214392reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Ciencia e Innovación https://doi.org/10.13039/501100004837 CEX2018-000806-Sopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2862172026-06-06T12:50:31Z
dc.title.none.fl_str_mv Impact of tobacco, alcohol, and marijuana on genome-wide DNA methylation and its relationship with hypertension
title Impact of tobacco, alcohol, and marijuana on genome-wide DNA methylation and its relationship with hypertension
spellingShingle Impact of tobacco, alcohol, and marijuana on genome-wide DNA methylation and its relationship with hypertension
Carreras-Gallo, Natàlia|||0000-0001-8559-2313
Tobacco
Alcohol
Marijuana
DNA methylation
Epigenome-wide association study
Hypertension
title_short Impact of tobacco, alcohol, and marijuana on genome-wide DNA methylation and its relationship with hypertension
title_full Impact of tobacco, alcohol, and marijuana on genome-wide DNA methylation and its relationship with hypertension
title_fullStr Impact of tobacco, alcohol, and marijuana on genome-wide DNA methylation and its relationship with hypertension
title_full_unstemmed Impact of tobacco, alcohol, and marijuana on genome-wide DNA methylation and its relationship with hypertension
title_sort Impact of tobacco, alcohol, and marijuana on genome-wide DNA methylation and its relationship with hypertension
dc.creator.none.fl_str_mv Carreras-Gallo, Natàlia|||0000-0001-8559-2313
Dwaraka, Varun B.
Cáceres, Alejandro|||0000-0001-8551-6695
Smith, Ryan|||0000-0002-3880-9740
Mendez, Tavis L.
Went, Hannah
González, Juan Ramón|||0000-0003-3267-2146
author Carreras-Gallo, Natàlia|||0000-0001-8559-2313
author_facet Carreras-Gallo, Natàlia|||0000-0001-8559-2313
Dwaraka, Varun B.
Cáceres, Alejandro|||0000-0001-8551-6695
Smith, Ryan|||0000-0002-3880-9740
Mendez, Tavis L.
Went, Hannah
González, Juan Ramón|||0000-0003-3267-2146
author_role author
author2 Dwaraka, Varun B.
Cáceres, Alejandro|||0000-0001-8551-6695
Smith, Ryan|||0000-0002-3880-9740
Mendez, Tavis L.
Went, Hannah
González, Juan Ramón|||0000-0003-3267-2146
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Tobacco
Alcohol
Marijuana
DNA methylation
Epigenome-wide association study
Hypertension
topic Tobacco
Alcohol
Marijuana
DNA methylation
Epigenome-wide association study
Hypertension
description Tobacco, alcohol, and marijuana consumption is an important public health problem because of their high use worldwide and their association with the risk of mortality and many health conditions, such as hypertension, which is the commonest risk factor for death throughout the world. A likely pathway of action of substance consumption leading to persistent hypertension is DNA methylation. Here, we evaluated the effects of tobacco, alcohol, and marijuana on DNA methylation in the same cohort (N = 3,424). Three epigenome-wide association studies (EWAS) were assessed in whole blood using the InfiniumHumanMethylationEPIC BeadChip. We also evaluated the mediation of the top CpG sites in the association between substance consumption and hypertension. Our analyses showed 2,569 CpG sites differentially methylated by alcohol drinking and 528 by tobacco smoking. We did not find significant associations with marijuana consumption after correcting for multiple comparisons. We found 61 genes overlapping between alcohol and tobacco that were enriched in biological processes involved in the nervous and cardiovascular systems. In the mediation analysis, we found 66 CpG sites that significantly mediated the effect of alcohol consumption on hypertension. The top alcohol-related CpG site (cg06690548, P-value = 5.9·10 -83) mapped to SLC7A11 strongly mediated 70.5% of the effect of alcohol consumption on hypertension (P-value = 0.006). Our findings suggest that DNA methylation should be considered for new targets in hypertension prevention and management, particularly concerning alcohol consumption. Our data also encourage further research into the use of methylation in blood to study the neurological and cardiovascular effects of substance consumption.
publishDate 2023
dc.date.none.fl_str_mv 2
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/286217
https://dx.doi.org/urn:doi:10.1080/15592294.2023.2214392
url https://ddd.uab.cat/record/286217
https://dx.doi.org/urn:doi:10.1080/15592294.2023.2214392
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 CEX2018-000806-S
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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