Micellar Nanocarriers from Dendritic Macromolecules Containing Fluorescent Coumarin Moieties

The design of efficient drug-delivery vehicles remains a big challenge in materials science. Herein, we describe a novel class of amphiphilic hybrid dendrimers that consist of a poly(amidoamine) (PAMAM) dendritic core functionalized with <i>bis</i>MPA dendrons bearing cholesterol and cou...

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Detalles Bibliográficos
Autores: Concellón, Alberto, San Anselmo, María, Hernández-Ainsa, Silvia, Romero, Pilar, Marcos, Mercedes, Serrano, José Luis
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/225666
Acceso en línea:http://hdl.handle.net/10261/225666
Access Level:acceso abierto
Palabra clave:Dendrimers
Liquid crystals
Nanocarriers
Self-assembly
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spelling Micellar Nanocarriers from Dendritic Macromolecules Containing Fluorescent Coumarin MoietiesConcellón, AlbertoSan Anselmo, MaríaHernández-Ainsa, SilviaRomero, PilarMarcos, MercedesSerrano, José LuisDendrimersLiquid crystalsNanocarriersSelf-assemblyThe design of efficient drug-delivery vehicles remains a big challenge in materials science. Herein, we describe a novel class of amphiphilic hybrid dendrimers that consist of a poly(amidoamine) (PAMAM) dendritic core functionalized with <i>bis</i>MPA dendrons bearing cholesterol and coumarin moieties. Their self-assembly behavior both in bulk and in water was investigated. All dendrimers exhibited smectic A or hexagonal columnar liquid crystal organizations, depending on the generation of the dendrimer. In water, these dendrimers self-assembled to form stable spherical micelles that could encapsulate Nile Red, a hydrophobic model compound. The cell viability in vitro of the micelles was studied in HeLa cell line, and proved to be non-toxic up to 72 h of incubation. Therefore, these spherical micelles allow the encapsulation of hydrophobic molecules, and at the same time provided fluorescent traceability due to the presence of coumarin units in their chemical structure, demonstrating the potential of these dendrimers as nanocarriers for drug-delivery applications.This work was supported by the MINECO-FEDER funds (PGC2018-097583-B-I00) and Gobierno de Aragón-FEDER (Research Group E47_17R).Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Ciencia, Innovación y Universidades (España)Gobierno de AragónConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2020202020202020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/225666reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-097583-B-I00Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2256662026-05-22T06:33:51Z
dc.title.none.fl_str_mv Micellar Nanocarriers from Dendritic Macromolecules Containing Fluorescent Coumarin Moieties
title Micellar Nanocarriers from Dendritic Macromolecules Containing Fluorescent Coumarin Moieties
spellingShingle Micellar Nanocarriers from Dendritic Macromolecules Containing Fluorescent Coumarin Moieties
Concellón, Alberto
Dendrimers
Liquid crystals
Nanocarriers
Self-assembly
title_short Micellar Nanocarriers from Dendritic Macromolecules Containing Fluorescent Coumarin Moieties
title_full Micellar Nanocarriers from Dendritic Macromolecules Containing Fluorescent Coumarin Moieties
title_fullStr Micellar Nanocarriers from Dendritic Macromolecules Containing Fluorescent Coumarin Moieties
title_full_unstemmed Micellar Nanocarriers from Dendritic Macromolecules Containing Fluorescent Coumarin Moieties
title_sort Micellar Nanocarriers from Dendritic Macromolecules Containing Fluorescent Coumarin Moieties
dc.creator.none.fl_str_mv Concellón, Alberto
San Anselmo, María
Hernández-Ainsa, Silvia
Romero, Pilar
Marcos, Mercedes
Serrano, José Luis
author Concellón, Alberto
author_facet Concellón, Alberto
San Anselmo, María
Hernández-Ainsa, Silvia
Romero, Pilar
Marcos, Mercedes
Serrano, José Luis
author_role author
author2 San Anselmo, María
Hernández-Ainsa, Silvia
Romero, Pilar
Marcos, Mercedes
Serrano, José Luis
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Gobierno de Aragón
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Dendrimers
Liquid crystals
Nanocarriers
Self-assembly
topic Dendrimers
Liquid crystals
Nanocarriers
Self-assembly
description The design of efficient drug-delivery vehicles remains a big challenge in materials science. Herein, we describe a novel class of amphiphilic hybrid dendrimers that consist of a poly(amidoamine) (PAMAM) dendritic core functionalized with <i>bis</i>MPA dendrons bearing cholesterol and coumarin moieties. Their self-assembly behavior both in bulk and in water was investigated. All dendrimers exhibited smectic A or hexagonal columnar liquid crystal organizations, depending on the generation of the dendrimer. In water, these dendrimers self-assembled to form stable spherical micelles that could encapsulate Nile Red, a hydrophobic model compound. The cell viability in vitro of the micelles was studied in HeLa cell line, and proved to be non-toxic up to 72 h of incubation. Therefore, these spherical micelles allow the encapsulation of hydrophobic molecules, and at the same time provided fluorescent traceability due to the presence of coumarin units in their chemical structure, demonstrating the potential of these dendrimers as nanocarriers for drug-delivery applications.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/225666
url http://hdl.handle.net/10261/225666
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-097583-B-I00
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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