The DREAM complex promotes gene body H2A.Z for target repression

The DREAM (DP, Retinoblastoma [Rb]-like, E2F, and MuvB) complex controls cellular quiescence by repressing cell cycle genes, but its mechanism of action is poorly understood. Here we show that Caenorhabditis elegans DREAM targets have an unusual pattern of high gene body HTZ-1/H2A.Z. In mutants of l...

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Detalles Bibliográficos
Autores: Latorre, Isabel, Chesney, Michael A., Garrigues, Jacob M., Stempor, Przemyslaw, Appert, Alex, Francesconi, Mirko, Strome, Susan, Ahringer, Julie
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/25040
Acceso en línea:http://hdl.handle.net/10230/25040
http://dx.doi.org/10.1101/gad.255810.114
Access Level:acceso abierto
Palabra clave:Histones
Proteïnes -- Metabolisme
C. elegans
H2A.Z
Retinoblastoma/DREAM
Transcriptional repression
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spelling The DREAM complex promotes gene body H2A.Z for target repressionLatorre, IsabelChesney, Michael A.Garrigues, Jacob M.Stempor, PrzemyslawAppert, AlexFrancesconi, MirkoStrome, SusanAhringer, JulieHistonesProteïnes -- MetabolismeC. elegansH2A.ZRetinoblastoma/DREAMTranscriptional repressionThe DREAM (DP, Retinoblastoma [Rb]-like, E2F, and MuvB) complex controls cellular quiescence by repressing cell cycle genes, but its mechanism of action is poorly understood. Here we show that Caenorhabditis elegans DREAM targets have an unusual pattern of high gene body HTZ-1/H2A.Z. In mutants of lin-35, the sole p130/Rb-like gene in C. elegans, DREAM targets have reduced gene body HTZ-1/H2A.Z and increased expression. Consistent with a repressive role for gene body H2A.Z, many DREAM targets are up-regulated in htz-1/ H2A.Z mutants. Our results indicate that the DREAM complex facilitates high gene body HTZ-1/H2A.Z, which plays a role in target gene repression.Cold Spring Harbor Laboratory Press201520152015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/25040http://dx.doi.org/10.1101/gad.255810.114reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraCatalánGenes & development. 2015; 29(5): 495-500© 2015 Latorre et al. This article, published in Genes & Development, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/250402026-06-12T07:21:37Z
dc.title.none.fl_str_mv The DREAM complex promotes gene body H2A.Z for target repression
title The DREAM complex promotes gene body H2A.Z for target repression
spellingShingle The DREAM complex promotes gene body H2A.Z for target repression
Latorre, Isabel
Histones
Proteïnes -- Metabolisme
C. elegans
H2A.Z
Retinoblastoma/DREAM
Transcriptional repression
title_short The DREAM complex promotes gene body H2A.Z for target repression
title_full The DREAM complex promotes gene body H2A.Z for target repression
title_fullStr The DREAM complex promotes gene body H2A.Z for target repression
title_full_unstemmed The DREAM complex promotes gene body H2A.Z for target repression
title_sort The DREAM complex promotes gene body H2A.Z for target repression
dc.creator.none.fl_str_mv Latorre, Isabel
Chesney, Michael A.
Garrigues, Jacob M.
Stempor, Przemyslaw
Appert, Alex
Francesconi, Mirko
Strome, Susan
Ahringer, Julie
author Latorre, Isabel
author_facet Latorre, Isabel
Chesney, Michael A.
Garrigues, Jacob M.
Stempor, Przemyslaw
Appert, Alex
Francesconi, Mirko
Strome, Susan
Ahringer, Julie
author_role author
author2 Chesney, Michael A.
Garrigues, Jacob M.
Stempor, Przemyslaw
Appert, Alex
Francesconi, Mirko
Strome, Susan
Ahringer, Julie
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Histones
Proteïnes -- Metabolisme
C. elegans
H2A.Z
Retinoblastoma/DREAM
Transcriptional repression
topic Histones
Proteïnes -- Metabolisme
C. elegans
H2A.Z
Retinoblastoma/DREAM
Transcriptional repression
description The DREAM (DP, Retinoblastoma [Rb]-like, E2F, and MuvB) complex controls cellular quiescence by repressing cell cycle genes, but its mechanism of action is poorly understood. Here we show that Caenorhabditis elegans DREAM targets have an unusual pattern of high gene body HTZ-1/H2A.Z. In mutants of lin-35, the sole p130/Rb-like gene in C. elegans, DREAM targets have reduced gene body HTZ-1/H2A.Z and increased expression. Consistent with a repressive role for gene body H2A.Z, many DREAM targets are up-regulated in htz-1/ H2A.Z mutants. Our results indicate that the DREAM complex facilitates high gene body HTZ-1/H2A.Z, which plays a role in target gene repression.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015
2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/25040
http://dx.doi.org/10.1101/gad.255810.114
url http://hdl.handle.net/10230/25040
http://dx.doi.org/10.1101/gad.255810.114
dc.language.none.fl_str_mv Catalán
language_invalid_str_mv Catalán
dc.relation.none.fl_str_mv Genes & development. 2015; 29(5): 495-500
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cold Spring Harbor Laboratory Press
publisher.none.fl_str_mv Cold Spring Harbor Laboratory Press
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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