Prepandemic personal concentrations of per- and polyfluoroalkyl substances (PFAS) and other pollutants: Specific and combined effects on the incidence of COVID-19 disease and SARS-CoV-2 infection

Objective: To investigate the specific and combined effects of personal concentrations of some per- and polyfluoroalkyl substances (PFAS), other persistent organic pollutants (POPs), and chemical elements -measured in individuals' blood several years before the pandemic- on the development...

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Authors: Pumarega Rodríguez, José Antonio, Gasull Panadès, Magda, Koponen, Jani, Campi, Laura, Rantakokko, Panu, Henríquez Hernández, Luis Alberto, Aguilar, Ruth, Donat-Vargas, Carolina, Zumbado, Manuel, Villar García, Judit, Rius, Cristina, Santiago-Díaz, Pablo, Vidal, Marta, Jiménez Morera, Alfons, Iglesias Coma, Mar, Dobaño, Carlota, Moncunill, Gemma, Porta, Miquel
Format: article
Status:Versión aceptada para publicación
Publication Date:2023
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/60150
Online Access:http://hdl.handle.net/10230/60150
http://dx.doi.org/10.1016/j.envres.2023.116965
Access Level:Open access
Keyword:COVID-19
Immunotoxicity
Mixtures
Per- and polyfluoroalkyl substances (PFAS)
SARS-CoV-2
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oai_identifier_str oai:recercat.cat:10230/60150
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Prepandemic personal concentrations of per- and polyfluoroalkyl substances (PFAS) and other pollutants: Specific and combined effects on the incidence of COVID-19 disease and SARS-CoV-2 infection
title Prepandemic personal concentrations of per- and polyfluoroalkyl substances (PFAS) and other pollutants: Specific and combined effects on the incidence of COVID-19 disease and SARS-CoV-2 infection
spellingShingle Prepandemic personal concentrations of per- and polyfluoroalkyl substances (PFAS) and other pollutants: Specific and combined effects on the incidence of COVID-19 disease and SARS-CoV-2 infection
Pumarega Rodríguez, José Antonio
COVID-19
Immunotoxicity
Mixtures
Per- and polyfluoroalkyl substances (PFAS)
SARS-CoV-2
title_short Prepandemic personal concentrations of per- and polyfluoroalkyl substances (PFAS) and other pollutants: Specific and combined effects on the incidence of COVID-19 disease and SARS-CoV-2 infection
title_full Prepandemic personal concentrations of per- and polyfluoroalkyl substances (PFAS) and other pollutants: Specific and combined effects on the incidence of COVID-19 disease and SARS-CoV-2 infection
title_fullStr Prepandemic personal concentrations of per- and polyfluoroalkyl substances (PFAS) and other pollutants: Specific and combined effects on the incidence of COVID-19 disease and SARS-CoV-2 infection
title_full_unstemmed Prepandemic personal concentrations of per- and polyfluoroalkyl substances (PFAS) and other pollutants: Specific and combined effects on the incidence of COVID-19 disease and SARS-CoV-2 infection
title_sort Prepandemic personal concentrations of per- and polyfluoroalkyl substances (PFAS) and other pollutants: Specific and combined effects on the incidence of COVID-19 disease and SARS-CoV-2 infection
dc.creator.none.fl_str_mv Pumarega Rodríguez, José Antonio
Gasull Panadès, Magda
Koponen, Jani
Campi, Laura
Rantakokko, Panu
Henríquez Hernández, Luis Alberto
Aguilar, Ruth
Donat-Vargas, Carolina
Zumbado, Manuel
Villar García, Judit
Rius, Cristina
Santiago-Díaz, Pablo
Vidal, Marta
Jiménez Morera, Alfons
Iglesias Coma, Mar
Dobaño, Carlota
Moncunill, Gemma
Porta, Miquel
author Pumarega Rodríguez, José Antonio
author_facet Pumarega Rodríguez, José Antonio
Gasull Panadès, Magda
Koponen, Jani
Campi, Laura
Rantakokko, Panu
Henríquez Hernández, Luis Alberto
Aguilar, Ruth
Donat-Vargas, Carolina
Zumbado, Manuel
Villar García, Judit
Rius, Cristina
Santiago-Díaz, Pablo
Vidal, Marta
Jiménez Morera, Alfons
Iglesias Coma, Mar
Dobaño, Carlota
Moncunill, Gemma
Porta, Miquel
author_role author
author2 Gasull Panadès, Magda
Koponen, Jani
Campi, Laura
Rantakokko, Panu
Henríquez Hernández, Luis Alberto
Aguilar, Ruth
Donat-Vargas, Carolina
Zumbado, Manuel
Villar García, Judit
Rius, Cristina
Santiago-Díaz, Pablo
Vidal, Marta
Jiménez Morera, Alfons
Iglesias Coma, Mar
Dobaño, Carlota
Moncunill, Gemma
Porta, Miquel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv COVID-19
Immunotoxicity
Mixtures
Per- and polyfluoroalkyl substances (PFAS)
SARS-CoV-2
topic COVID-19
Immunotoxicity
Mixtures
Per- and polyfluoroalkyl substances (PFAS)
SARS-CoV-2
description Objective: To investigate the specific and combined effects of personal concentrations of some per- and polyfluoroalkyl substances (PFAS), other persistent organic pollutants (POPs), and chemical elements -measured in individuals' blood several years before the pandemic- on the development of SARS-CoV-2 infection and COVID-19 disease in the general population. Methods: We conducted a prospective cohort study in 240 individuals from the general population of Barcelona. PFAS, other POPs, and chemical elements were measured in plasma, serum, and whole blood samples, respectively, collected in 2016-2017. PFAS were analyzed by liquid chromatography-triple quadrupole mass spectrometry. SARS-CoV-2 infection was detected by rRT-PCR in nasopharyngeal swabs and/or antibody serology in blood samples collected in 2020-2021. Results: No individual PFAS nor their mixtures were significantly associated with SARS-CoV-2 seropositivity or COVID-19 disease. Previously identified mixtures of POPs and elements (Porta et al., 2023) remained significantly associated with seropositivity and COVID-19 when adjusted for PFAS (all OR > 4 or p < 0.05). Nine chemicals comprised mixtures associated with COVID-19: thallium, ruthenium, lead, benzo[b]fluoranthene, DDD, other DDT-related compounds, manganese, tantalum, and aluminium. And nine chemicals comprised the mixtures more consistently associated with SARS-CoV-2 seropositivity: thallium, ruthenium, lead, benzo[b]fluoranthene, DDD, gold, and (protectively) selenium, indium, and iron. Conclusions: The PFAS studied were not associated with SARS-CoV-2 seropositivity or COVID-19. The results confirm the associations between personal blood concentrations of some POPs and chemical elements and the risk of COVID-19 and SARS-CoV-2 infection in what remains the only prospective and population-based cohort study on the topic. Mixtures of POPs and chemical elements may contribute to explain the heterogeneity in the risks of SARS-CoV-2 infection and COVID-19 in the general population.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/60150
http://dx.doi.org/10.1016/j.envres.2023.116965
url http://hdl.handle.net/10230/60150
http://dx.doi.org/10.1016/j.envres.2023.116965
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Environ Res. 2023 Nov 15;237(Pt 2):116965
info:eu-repo/grantAgreement/ES/2PE/CEX2018-000806-S
dc.rights.none.fl_str_mv © Elsevier http://dx.doi.org/10.1016/j.envres.2023.116965
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © Elsevier http://dx.doi.org/10.1016/j.envres.2023.116965
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Prepandemic personal concentrations of per- and polyfluoroalkyl substances (PFAS) and other pollutants: Specific and combined effects on the incidence of COVID-19 disease and SARS-CoV-2 infectionPumarega Rodríguez, José AntonioGasull Panadès, MagdaKoponen, JaniCampi, LauraRantakokko, PanuHenríquez Hernández, Luis AlbertoAguilar, RuthDonat-Vargas, CarolinaZumbado, ManuelVillar García, JuditRius, CristinaSantiago-Díaz, PabloVidal, MartaJiménez Morera, AlfonsIglesias Coma, MarDobaño, CarlotaMoncunill, GemmaPorta, MiquelCOVID-19ImmunotoxicityMixturesPer- and polyfluoroalkyl substances (PFAS)SARS-CoV-2Objective: To investigate the specific and combined effects of personal concentrations of some per- and polyfluoroalkyl substances (PFAS), other persistent organic pollutants (POPs), and chemical elements -measured in individuals' blood several years before the pandemic- on the development of SARS-CoV-2 infection and COVID-19 disease in the general population. Methods: We conducted a prospective cohort study in 240 individuals from the general population of Barcelona. PFAS, other POPs, and chemical elements were measured in plasma, serum, and whole blood samples, respectively, collected in 2016-2017. PFAS were analyzed by liquid chromatography-triple quadrupole mass spectrometry. SARS-CoV-2 infection was detected by rRT-PCR in nasopharyngeal swabs and/or antibody serology in blood samples collected in 2020-2021. Results: No individual PFAS nor their mixtures were significantly associated with SARS-CoV-2 seropositivity or COVID-19 disease. Previously identified mixtures of POPs and elements (Porta et al., 2023) remained significantly associated with seropositivity and COVID-19 when adjusted for PFAS (all OR > 4 or p < 0.05). Nine chemicals comprised mixtures associated with COVID-19: thallium, ruthenium, lead, benzo[b]fluoranthene, DDD, other DDT-related compounds, manganese, tantalum, and aluminium. And nine chemicals comprised the mixtures more consistently associated with SARS-CoV-2 seropositivity: thallium, ruthenium, lead, benzo[b]fluoranthene, DDD, gold, and (protectively) selenium, indium, and iron. Conclusions: The PFAS studied were not associated with SARS-CoV-2 seropositivity or COVID-19. The results confirm the associations between personal blood concentrations of some POPs and chemical elements and the risk of COVID-19 and SARS-CoV-2 infection in what remains the only prospective and population-based cohort study on the topic. Mixtures of POPs and chemical elements may contribute to explain the heterogeneity in the risks of SARS-CoV-2 infection and COVID-19 in the general population.The work was supported in part by research grants from Instituto de Salud Carlos III, Government of Spain, co-funded by FEDER (FIS PI17/00088, FIS PI21/00052, and CIBER de Epidemiología y Salud Pública - CIBERESP); CRUE-Santander Fondo Supera Covid-19 (15072020); the Hospital del Mar Medical Research Institute (IMIM), Barcelona; and the Government of Catalonia (2017 SGR 439; 2021 SGR 43). GM is supported by RYC2020-029886-I/AEI/10.13039/501100011033, co-funded by European Social Fund (ESF). Development of SARS-CoV-2 reagents was partially supported by the NIAID Centers of Excellence for Influenza Research and Surveillance (CEIRS) contract HHSN272201400008C. ISGlobal acknowledges support from the Spanish Ministry of Science and Innovation and State Research Agency through the ‘Centro de Excelencia Severo Ochoa 2019–2023’ Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Elsevier202420252023info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/60150http://dx.doi.org/10.1016/j.envres.2023.116965reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésEnviron Res. 2023 Nov 15;237(Pt 2):116965info:eu-repo/grantAgreement/ES/2PE/CEX2018-000806-S© Elsevier http://dx.doi.org/10.1016/j.envres.2023.116965info:eu-repo/semantics/openAccessoai:recercat.cat:10230/601502026-05-29T05:05:01Z
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