Editorial: Glial crosstalk in neurological disorders
Neurons have been focused as a main target for investigation of pathogenesis and therapeutics in neurological disorders. Although some of the mechanisms, including oxidative stress and inflammation, followed by apoptosis, are thought to be involved in the pathogenesis of these diseases, pathological...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/378217 |
| Acceso en línea: | http://hdl.handle.net/10261/378217 https://api.elsevier.com/content/abstract/scopus_id/85210165045 |
| Access Level: | acceso abierto |
| Palabra clave: | Astrocyte Glia Glial interaction Microglia Neurological disorder Oligodendrocyte |
| Sumario: | Neurons have been focused as a main target for investigation of pathogenesis and therapeutics in neurological disorders. Although some of the mechanisms, including oxidative stress and inflammation, followed by apoptosis, are thought to be involved in the pathogenesis of these diseases, pathological mechanism remains unknown. There is a consensus on the involvement of non-neuronal cells in the pathological progression. Recently, glial cells are getting attention as a key players of non-cell autonomous neurodegeneration in neurological disorders. Especially, glial crosstalk and its action on neurons are highlighted. It is demonstrated that microglia convert astrocytes to neurotoxic reactive A1 astrocytes (Liddelow, et al., 2017). In contrast, it is also reported that astrocytes activate microglia to produce neuroinflammation (Rohl and Sievers, 2005). Besides, astrocyte-microglia crosstalk contributes to degradation of protein aggregates (Rostami, et al., 2021). Furthermore, recent studies indicated microglia-oligodendrocyte or astrocyte-oligodendrocyte interaction promoted neuronal dysfunction and neurodegeneration (Lohrberg, et al., 2020; Papazian, et al., 2021). Thus, glial communication could be a main target to understand pathological mechanism and develop neuroprotective therapeutic approach. This series includes five articles covering different aspect of the Research Topic outlined above. |
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