In vivo assessment of marine vs bovine origin collagen-based composite scaffolds promoting bone regeneration in a New Zealand rabbit model
13 pages, 8 figures.-- Under a Creative Commons license
| Autores: | , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/350682 |
| Acceso en línea: | http://hdl.handle.net/10261/350682 |
| Access Level: | acceso abierto |
| Palabra clave: | Fish collagen Apatite Blue shark Bone regeneration New Zealand rabbit Marine biomaterials http://aims.fao.org/aos/agrovoc/c_1755 http://aims.fao.org/aos/agrovoc/c_5bbf486b http://aims.fao.org/aos/agrovoc/c_7028 collagen apatite sharks |
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In vivo assessment of marine vs bovine origin collagen-based composite scaffolds promoting bone regeneration in a New Zealand rabbit modelDiogo, Gabriela S.Permuy, MaríaMarques, Catarina F.González Sotelo, CarmenPérez Martín, Ricardo IsaacSerra, JuliaGonzález, PioMuñoz, FernandoPirraco, Rogério P.Reis, Rui L.Silva, Tiago H.Fish collagenApatiteBlue sharkBone regenerationNew Zealand rabbitMarine biomaterialshttp://aims.fao.org/aos/agrovoc/c_1755http://aims.fao.org/aos/agrovoc/c_5bbf486bhttp://aims.fao.org/aos/agrovoc/c_7028collagenapatitesharks13 pages, 8 figures.-- Under a Creative Commons licenseThe ability of human tissues to self-repair is limited, which motivates the scientific community to explore new and better therapeutic approaches to tissue regeneration. The present manuscript provides a comparative study between a marine-based composite biomaterial, and another composed of well-established counterparts for bone tissue regeneration. Blue shark skin collagen was combined with bioapatite obtained from blue shark's teeth (mColl:BAp), while bovine collagen was combined with synthetic hydroxyapatite (bColl:Ap) to produce 3D composite scaffolds by freeze-drying. Collagens showed similar profiles, while apatite particles differed in their composition, being the marine bioapatite a fluoride-enriched ceramic. The marine-sourced biomaterials presented higher porosities, improved mechanical properties, and slower degradation rates when compared to synthetic apatite-reinforced bovine collagen. The in vivo performance regarding bone tissue regeneration was evaluated in defects created in femoral condyles in New Zealand rabbits twelve weeks post-surgery. Micro-CT results showed that mColl:BAp implanted condyles had a slower degradation and an higher tissue formation (17.9 ± 6.9 %) when compared with bColl:Ap implanted ones (12.9 ± 7.6 %). The histomorphometry analysis provided supporting evidence, confirming the observed trend by quantifying 13.1 ± 7.9 % of new tissue formation for mColl:BAp composites and 10.4 ± 3.2 % for bColl:Ap composites, suggesting the potential use of marine biomaterials for bone regenerationThis study was funded by the Portuguese Foundation for Science and Technology (FCT) under the scope of the BiogenInk project (M-ERA-NET2/0022/2016), by European Regional Development Fund through INTERREG Spain-Portugal Programme, under the scope of 0245_IBEROS_1_E project, through INTERREG Atlantic Area Programme, under the scope of BLUEHUMAN (EAPA_151/2016) project and through Northern Portugal Regional Operational Program (NORTE 2020), under the scope of Structured project NORTE-01-0145-FEDER-000021. The Doctoral Programme NORTE-08-5369-FSE-000044 supported by NORTE 2020, under the PORTUGAL 2020 Partnership Agreement, through the European Social Fund, is also greatly acknowledged by the PhD fellowship of GSD. RP and CM thank FCT for the research contracts IF/00347/2015 and CEECIND/04687/2017, respectivelyPeer reviewedElsevierFundação para a Ciência e a Tecnologia (Portugal)European CommissionDiogo, Gabriela S. [0000-0002-5696-631X]Permuy, María [0000-0002-3708-4821]González Sotelo, Carmen [0000-0002-0726-4370]Pérez Martín, Ricardo Isaac [0000-0002-4918-9399]Muñoz, Fernando [0000-0002-4130-1526]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/350682reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésNo data was used for the research described in the articlehttps://doi.org/10.1016/j.bioadv.2024.213813Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3506822026-05-22T06:33:51Z |
| dc.title.none.fl_str_mv |
In vivo assessment of marine vs bovine origin collagen-based composite scaffolds promoting bone regeneration in a New Zealand rabbit model |
| title |
In vivo assessment of marine vs bovine origin collagen-based composite scaffolds promoting bone regeneration in a New Zealand rabbit model |
| spellingShingle |
In vivo assessment of marine vs bovine origin collagen-based composite scaffolds promoting bone regeneration in a New Zealand rabbit model Diogo, Gabriela S. Fish collagen Apatite Blue shark Bone regeneration New Zealand rabbit Marine biomaterials http://aims.fao.org/aos/agrovoc/c_1755 http://aims.fao.org/aos/agrovoc/c_5bbf486b http://aims.fao.org/aos/agrovoc/c_7028 collagen apatite sharks |
| title_short |
In vivo assessment of marine vs bovine origin collagen-based composite scaffolds promoting bone regeneration in a New Zealand rabbit model |
| title_full |
In vivo assessment of marine vs bovine origin collagen-based composite scaffolds promoting bone regeneration in a New Zealand rabbit model |
| title_fullStr |
In vivo assessment of marine vs bovine origin collagen-based composite scaffolds promoting bone regeneration in a New Zealand rabbit model |
| title_full_unstemmed |
In vivo assessment of marine vs bovine origin collagen-based composite scaffolds promoting bone regeneration in a New Zealand rabbit model |
| title_sort |
In vivo assessment of marine vs bovine origin collagen-based composite scaffolds promoting bone regeneration in a New Zealand rabbit model |
| dc.creator.none.fl_str_mv |
Diogo, Gabriela S. Permuy, María Marques, Catarina F. González Sotelo, Carmen Pérez Martín, Ricardo Isaac Serra, Julia González, Pio Muñoz, Fernando Pirraco, Rogério P. Reis, Rui L. Silva, Tiago H. |
| author |
Diogo, Gabriela S. |
| author_facet |
Diogo, Gabriela S. Permuy, María Marques, Catarina F. González Sotelo, Carmen Pérez Martín, Ricardo Isaac Serra, Julia González, Pio Muñoz, Fernando Pirraco, Rogério P. Reis, Rui L. Silva, Tiago H. |
| author_role |
author |
| author2 |
Permuy, María Marques, Catarina F. González Sotelo, Carmen Pérez Martín, Ricardo Isaac Serra, Julia González, Pio Muñoz, Fernando Pirraco, Rogério P. Reis, Rui L. Silva, Tiago H. |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Fundação para a Ciência e a Tecnologia (Portugal) European Commission Diogo, Gabriela S. [0000-0002-5696-631X] Permuy, María [0000-0002-3708-4821] González Sotelo, Carmen [0000-0002-0726-4370] Pérez Martín, Ricardo Isaac [0000-0002-4918-9399] Muñoz, Fernando [0000-0002-4130-1526] Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
Fish collagen Apatite Blue shark Bone regeneration New Zealand rabbit Marine biomaterials http://aims.fao.org/aos/agrovoc/c_1755 http://aims.fao.org/aos/agrovoc/c_5bbf486b http://aims.fao.org/aos/agrovoc/c_7028 collagen apatite sharks |
| topic |
Fish collagen Apatite Blue shark Bone regeneration New Zealand rabbit Marine biomaterials http://aims.fao.org/aos/agrovoc/c_1755 http://aims.fao.org/aos/agrovoc/c_5bbf486b http://aims.fao.org/aos/agrovoc/c_7028 collagen apatite sharks |
| description |
13 pages, 8 figures.-- Under a Creative Commons license |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2024 2024 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10261/350682 |
| url |
http://hdl.handle.net/10261/350682 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
No data was used for the research described in the article https://doi.org/10.1016/j.bioadv.2024.213813 Sí |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
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reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC) |
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Consejo Superior de Investigaciones Científicas (CSIC) |
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DIGITAL.CSIC. Repositorio Institucional del CSIC |
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DIGITAL.CSIC. Repositorio Institucional del CSIC |
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1869416216035065856 |
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15.812429 |