Are delusions and/or referentiality associated with aberrant reward prediction error (RPE) signaling? Evidence from fMRI using a probabilistic monetary reward task.

BACKGROUND: According to the aberrant salience proposal, reward processing abnormality, specifically erroneous reward prediction error (RPE) signaling due to stimulus-independent release of dopamine, underlies delusions in schizophrenia. However, no studies to date have examined RPE-associated brain...

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Autores: García-León MÁ, Fuentes-Claramonte P, Gee A, Ramiro-Sousa N, Soler-Vidal J, Salgado-Pineda P, Torres L, Jaurrieta N, Sánchez-Pérez M, Panicali F, Inarejos Clemente EJ, Raduà J, Sarró S, Salvador R, McKenna PJ, Pomarol-Clotet E
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p27672
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=27672
Access Level:acceso abierto
Palabra clave:delusions
fMRI
referentiality
reward
reward prediction error
schizophrenia
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spelling Are delusions and/or referentiality associated with aberrant reward prediction error (RPE) signaling? Evidence from fMRI using a probabilistic monetary reward task.García-León MÁFuentes-Claramonte PGee ARamiro-Sousa NSoler-Vidal JSalgado-Pineda PTorres LJaurrieta NSánchez-Pérez MPanicali FInarejos Clemente EJRaduà JSarró SSalvador RMcKenna PJPomarol-Clotet EdelusionsfMRIreferentialityrewardreward prediction errorschizophreniaBACKGROUND: According to the aberrant salience proposal, reward processing abnormality, specifically erroneous reward prediction error (RPE) signaling due to stimulus-independent release of dopamine, underlies delusions in schizophrenia. However, no studies to date have examined RPE-associated brain activations in relation to this symptom. METHODS: Seventy-eight patients with a DSM-5 diagnosis of schizophrenia/schizoaffective disorder and 43 healthy individuals underwent fMRI while they performed a probabilistic monetary reward task designed to generate a measure of RPE. Ratings of delusions and referentiality were made in the patients. RESULTS: Using whole-brain, voxel-based analysis, schizophrenia patients showed only minor differences in RPE-associated activation compared to healthy controls. Within the patient group, however, severity of delusions was inversely associated with RPE-associated activation in areas including the caudate nucleus, the thalamus and the left pallidum, as well as the lateral frontal cortex bilaterally, the pre- and postcentral gyrus and supplementary motor area, the middle cingulate gyrus, and parts of the temporal and parietal cortex. A broadly similar pattern of association was seen for referentiality. CONCLUSIONS: According to this study, while patients with schizophrenia as a group do not show marked alterations in RPE signaling, delusions and referentiality are associated with reduced activation in parts of the prefrontal cortex and the basal ganglia, though not specifically the ventral striatum. The direction of the changes is on the face of it contrary to that predicted by aberrant salience theory.CAMBRIDGE UNIV PRESS2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=27672PSYCHOLOGICAL MEDICINEISSN: 00332917ISSNe: 14698978reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p276722026-05-27T12:37:41Z
dc.title.none.fl_str_mv Are delusions and/or referentiality associated with aberrant reward prediction error (RPE) signaling? Evidence from fMRI using a probabilistic monetary reward task.
title Are delusions and/or referentiality associated with aberrant reward prediction error (RPE) signaling? Evidence from fMRI using a probabilistic monetary reward task.
spellingShingle Are delusions and/or referentiality associated with aberrant reward prediction error (RPE) signaling? Evidence from fMRI using a probabilistic monetary reward task.
García-León MÁ
delusions
fMRI
referentiality
reward
reward prediction error
schizophrenia
title_short Are delusions and/or referentiality associated with aberrant reward prediction error (RPE) signaling? Evidence from fMRI using a probabilistic monetary reward task.
title_full Are delusions and/or referentiality associated with aberrant reward prediction error (RPE) signaling? Evidence from fMRI using a probabilistic monetary reward task.
title_fullStr Are delusions and/or referentiality associated with aberrant reward prediction error (RPE) signaling? Evidence from fMRI using a probabilistic monetary reward task.
title_full_unstemmed Are delusions and/or referentiality associated with aberrant reward prediction error (RPE) signaling? Evidence from fMRI using a probabilistic monetary reward task.
title_sort Are delusions and/or referentiality associated with aberrant reward prediction error (RPE) signaling? Evidence from fMRI using a probabilistic monetary reward task.
dc.creator.none.fl_str_mv García-León MÁ
Fuentes-Claramonte P
Gee A
Ramiro-Sousa N
Soler-Vidal J
Salgado-Pineda P
Torres L
Jaurrieta N
Sánchez-Pérez M
Panicali F
Inarejos Clemente EJ
Raduà J
Sarró S
Salvador R
McKenna PJ
Pomarol-Clotet E
author García-León MÁ
author_facet García-León MÁ
Fuentes-Claramonte P
Gee A
Ramiro-Sousa N
Soler-Vidal J
Salgado-Pineda P
Torres L
Jaurrieta N
Sánchez-Pérez M
Panicali F
Inarejos Clemente EJ
Raduà J
Sarró S
Salvador R
McKenna PJ
Pomarol-Clotet E
author_role author
author2 Fuentes-Claramonte P
Gee A
Ramiro-Sousa N
Soler-Vidal J
Salgado-Pineda P
Torres L
Jaurrieta N
Sánchez-Pérez M
Panicali F
Inarejos Clemente EJ
Raduà J
Sarró S
Salvador R
McKenna PJ
Pomarol-Clotet E
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv delusions
fMRI
referentiality
reward
reward prediction error
schizophrenia
topic delusions
fMRI
referentiality
reward
reward prediction error
schizophrenia
description BACKGROUND: According to the aberrant salience proposal, reward processing abnormality, specifically erroneous reward prediction error (RPE) signaling due to stimulus-independent release of dopamine, underlies delusions in schizophrenia. However, no studies to date have examined RPE-associated brain activations in relation to this symptom. METHODS: Seventy-eight patients with a DSM-5 diagnosis of schizophrenia/schizoaffective disorder and 43 healthy individuals underwent fMRI while they performed a probabilistic monetary reward task designed to generate a measure of RPE. Ratings of delusions and referentiality were made in the patients. RESULTS: Using whole-brain, voxel-based analysis, schizophrenia patients showed only minor differences in RPE-associated activation compared to healthy controls. Within the patient group, however, severity of delusions was inversely associated with RPE-associated activation in areas including the caudate nucleus, the thalamus and the left pallidum, as well as the lateral frontal cortex bilaterally, the pre- and postcentral gyrus and supplementary motor area, the middle cingulate gyrus, and parts of the temporal and parietal cortex. A broadly similar pattern of association was seen for referentiality. CONCLUSIONS: According to this study, while patients with schizophrenia as a group do not show marked alterations in RPE signaling, delusions and referentiality are associated with reduced activation in parts of the prefrontal cortex and the basal ganglia, though not specifically the ventral striatum. The direction of the changes is on the face of it contrary to that predicted by aberrant salience theory.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=27672
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=27672
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv CAMBRIDGE UNIV PRESS
publisher.none.fl_str_mv CAMBRIDGE UNIV PRESS
dc.source.none.fl_str_mv PSYCHOLOGICAL MEDICINE
ISSN: 00332917
ISSNe: 14698978
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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