Role of the Growth Suppressor p27Kip1 During Vascular Remodeling

8 páginas, 4 figuras.-- El documento en word es la versión post-print.

Detalles Bibliográficos
Autores: Díez-Juan, Antonio, Castro, Claudia, Edo, María Dolores, Andrés, Vicente
Tipo de recurso: artículo
Fecha de publicación:2003
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/36873
Acceso en línea:http://hdl.handle.net/10261/36873
Access Level:acceso abierto
Palabra clave:Atherosclerosis
Restenosis
Neovascularization
Proliferation
Migration
p27
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spelling Role of the Growth Suppressor p27Kip1 During Vascular RemodelingDíez-Juan, AntonioCastro, ClaudiaEdo, María DoloresAndrés, VicenteAtherosclerosisRestenosisNeovascularizationProliferationMigrationp278 páginas, 4 figuras.-- El documento en word es la versión post-print.At homeostasis, vascular cells display a very low proliferative rate and a scant migratory activity. However, hyperplastic growth and locomotion of vascular cells are a hallmark of vascular remodeling during several pathophysiological conditions (e. g., neovascularization, arteriosclerosis and restenosis post-angioplasty). Thus, a better understanding of the molecular mechanisms that control vascular cell proliferation and migration should facilitate the development of novel therapies to treat cardiovascular disease. In this review, we will discuss recent studies implicating the cell cycle regulatory protein p27Kip1 as a key modulator of vascular cell growth and locomotion in vitro and during vascular remodeling in vivo.Work in the laboratory of V. Andrés is supported by the Spanish Ministry of Science and Technology and Fondo Europeo de Desarrollo Regional (FEDER) (grants SAF2001-2358 and SAF2002-1443) and by Generalitat Valenciana (grants GV01-488 and CTGCA/2002/04). C. Castro and M. D. Edo are recipients of a fellowship from Agencia Española de Cooperación Internacional and Generalitat Valenciana, respectively. A. Díez-Juan was partially supported from the Spanish DGESIC and FEDER (grant 1FD97-1035-C02-02), and from Fondo Social Europeo (CSIC-Programa I3P fellowship).Peer reviewedBentham Science Publishers201120112003info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/36873reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://www.benthamdirect.org/pages/content.php?CVP/2003/00000001/00000001/012AD.SGMinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/368732026-05-22T06:33:51Z
dc.title.none.fl_str_mv Role of the Growth Suppressor p27Kip1 During Vascular Remodeling
title Role of the Growth Suppressor p27Kip1 During Vascular Remodeling
spellingShingle Role of the Growth Suppressor p27Kip1 During Vascular Remodeling
Díez-Juan, Antonio
Atherosclerosis
Restenosis
Neovascularization
Proliferation
Migration
p27
title_short Role of the Growth Suppressor p27Kip1 During Vascular Remodeling
title_full Role of the Growth Suppressor p27Kip1 During Vascular Remodeling
title_fullStr Role of the Growth Suppressor p27Kip1 During Vascular Remodeling
title_full_unstemmed Role of the Growth Suppressor p27Kip1 During Vascular Remodeling
title_sort Role of the Growth Suppressor p27Kip1 During Vascular Remodeling
dc.creator.none.fl_str_mv Díez-Juan, Antonio
Castro, Claudia
Edo, María Dolores
Andrés, Vicente
author Díez-Juan, Antonio
author_facet Díez-Juan, Antonio
Castro, Claudia
Edo, María Dolores
Andrés, Vicente
author_role author
author2 Castro, Claudia
Edo, María Dolores
Andrés, Vicente
author2_role author
author
author
dc.subject.none.fl_str_mv Atherosclerosis
Restenosis
Neovascularization
Proliferation
Migration
p27
topic Atherosclerosis
Restenosis
Neovascularization
Proliferation
Migration
p27
description 8 páginas, 4 figuras.-- El documento en word es la versión post-print.
publishDate 2003
dc.date.none.fl_str_mv 2003
2011
2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/36873
url http://hdl.handle.net/10261/36873
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://www.benthamdirect.org/pages/content.php?CVP/2003/00000001/00000001/012AD.SGM
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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