CRUSADE bleeding risk score validation for ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention

Introduction: The CRUSADE bleeding risk score (CBRS) accurately predicts major bleeding in non-ST segment elevation myocardial infarction NSTEMI patients. However, little information exists about its application in ST segment elevation myocardial infarction STEMI. We aimed to assess the ability of C...

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Autores: Ariza Solé, Albert, Sánchez Elvira, Guillermo, Sánchez Salado, Jose Carlos, Lorente-Tordera, Victoria, Salazar Mendiguchía, Joel, Sánchez Prieto, Remedios, Romaguera-Torres, Rafael, Ferreiro Gutiérrez, José Luis, Gómez Hospital, Joan Antoni, Cequier Fillat, Àngel R.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2013
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/224884
Acceso en línea:https://hdl.handle.net/2445/224884
Access Level:acceso abierto
Palabra clave:Anticoagulants (Medicina)
Coagulació sanguínia
Hemorràgia
Infart de miocardi
Anticoagulants (Medicine)
Blood coagulation
Hemorrhage
Myocardial infarction
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spelling CRUSADE bleeding risk score validation for ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary interventionAriza Solé, AlbertSánchez Elvira, GuillermoSánchez Salado, Jose CarlosLorente-Tordera, VictoriaSalazar Mendiguchía, JoelSánchez Prieto, RemediosRomaguera-Torres, RafaelFerreiro Gutiérrez, José LuisGómez Hospital, Joan AntoniCequier Fillat, Àngel R.Anticoagulants (Medicina)Coagulació sanguíniaHemorràgiaInfart de miocardiAnticoagulants (Medicine)Blood coagulationHemorrhageMyocardial infarctionIntroduction: The CRUSADE bleeding risk score (CBRS) accurately predicts major bleeding in non-ST segment elevation myocardial infarction NSTEMI patients. However, little information exists about its application in ST segment elevation myocardial infarction STEMI. We aimed to assess the ability of CBRS to predict in-hospital major bleeding in STEMI patients undergoing primary percutaneous coronary intervention (PPCI). Materials and methods: We prospectively analyzed consecutive STEMI patients undergoing PPCI. Baseline characteristics, in-hospital complications and mid term mortality were recorded. Major bleeding was defined by the CRUSADE definition. Predictive ability of the CBRS was assessed by logistic regression method and the area under the ROC curve (AUC). Results: We included 1064 patients (mean age 63years). Mean CBRS value was 24. Most of patients (740/1064 (69.6%)) were in the two lowest risk quintiles of CBRS. Incidence of in-hospital major bleeding was 33/1064 (3.1%). The rates of in-hospital bleeding across the quintiles of risk groups were 0.4% (very low risk), 2.6% (low), 4.6% (moderate), 7.2% (high), and 13.4% (very high) (p 0.001). AUC was 0.80 (95% CI 0.73-0.87 p 0.001). In patients with radial access angiography (n=621) AUC was 0.81 (95% CI: 0.65-0.97). Mean follow up was 344days. Patients with bleeding events had higher mortality during follow up (HR 6.91; 95% CI 3.72-12.82; p 0.001). Conclusions: Our patients had a significantly lower bleeding risk as compared to CRUSADE NSTEMI population. CBRS accurately predicted major in-hospital bleeding in this different clinical scenario, including patients with radial artery approach.Elsevier Ltd.2025202520132025info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion22 p.application/pdfhttps://hdl.handle.net/2445/224884Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1016/j.thromres.2013.09.019Thrombosis Research, 2013, vol. 132, num.6, p. 652-658https://doi.org/10.1016/j.thromres.2013.09.019(c) Elsevier Ltd., 2013info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2248842026-05-29T05:05:01Z
dc.title.none.fl_str_mv CRUSADE bleeding risk score validation for ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention
title CRUSADE bleeding risk score validation for ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention
spellingShingle CRUSADE bleeding risk score validation for ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention
Ariza Solé, Albert
Anticoagulants (Medicina)
Coagulació sanguínia
Hemorràgia
Infart de miocardi
Anticoagulants (Medicine)
Blood coagulation
Hemorrhage
Myocardial infarction
title_short CRUSADE bleeding risk score validation for ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention
title_full CRUSADE bleeding risk score validation for ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention
title_fullStr CRUSADE bleeding risk score validation for ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention
title_full_unstemmed CRUSADE bleeding risk score validation for ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention
title_sort CRUSADE bleeding risk score validation for ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention
dc.creator.none.fl_str_mv Ariza Solé, Albert
Sánchez Elvira, Guillermo
Sánchez Salado, Jose Carlos
Lorente-Tordera, Victoria
Salazar Mendiguchía, Joel
Sánchez Prieto, Remedios
Romaguera-Torres, Rafael
Ferreiro Gutiérrez, José Luis
Gómez Hospital, Joan Antoni
Cequier Fillat, Àngel R.
author Ariza Solé, Albert
author_facet Ariza Solé, Albert
Sánchez Elvira, Guillermo
Sánchez Salado, Jose Carlos
Lorente-Tordera, Victoria
Salazar Mendiguchía, Joel
Sánchez Prieto, Remedios
Romaguera-Torres, Rafael
Ferreiro Gutiérrez, José Luis
Gómez Hospital, Joan Antoni
Cequier Fillat, Àngel R.
author_role author
author2 Sánchez Elvira, Guillermo
Sánchez Salado, Jose Carlos
Lorente-Tordera, Victoria
Salazar Mendiguchía, Joel
Sánchez Prieto, Remedios
Romaguera-Torres, Rafael
Ferreiro Gutiérrez, José Luis
Gómez Hospital, Joan Antoni
Cequier Fillat, Àngel R.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Anticoagulants (Medicina)
Coagulació sanguínia
Hemorràgia
Infart de miocardi
Anticoagulants (Medicine)
Blood coagulation
Hemorrhage
Myocardial infarction
topic Anticoagulants (Medicina)
Coagulació sanguínia
Hemorràgia
Infart de miocardi
Anticoagulants (Medicine)
Blood coagulation
Hemorrhage
Myocardial infarction
description Introduction: The CRUSADE bleeding risk score (CBRS) accurately predicts major bleeding in non-ST segment elevation myocardial infarction NSTEMI patients. However, little information exists about its application in ST segment elevation myocardial infarction STEMI. We aimed to assess the ability of CBRS to predict in-hospital major bleeding in STEMI patients undergoing primary percutaneous coronary intervention (PPCI). Materials and methods: We prospectively analyzed consecutive STEMI patients undergoing PPCI. Baseline characteristics, in-hospital complications and mid term mortality were recorded. Major bleeding was defined by the CRUSADE definition. Predictive ability of the CBRS was assessed by logistic regression method and the area under the ROC curve (AUC). Results: We included 1064 patients (mean age 63years). Mean CBRS value was 24. Most of patients (740/1064 (69.6%)) were in the two lowest risk quintiles of CBRS. Incidence of in-hospital major bleeding was 33/1064 (3.1%). The rates of in-hospital bleeding across the quintiles of risk groups were 0.4% (very low risk), 2.6% (low), 4.6% (moderate), 7.2% (high), and 13.4% (very high) (p 0.001). AUC was 0.80 (95% CI 0.73-0.87 p 0.001). In patients with radial access angiography (n=621) AUC was 0.81 (95% CI: 0.65-0.97). Mean follow up was 344days. Patients with bleeding events had higher mortality during follow up (HR 6.91; 95% CI 3.72-12.82; p 0.001). Conclusions: Our patients had a significantly lower bleeding risk as compared to CRUSADE NSTEMI population. CBRS accurately predicted major in-hospital bleeding in this different clinical scenario, including patients with radial artery approach.
publishDate 2013
dc.date.none.fl_str_mv 2013
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/224884
url https://hdl.handle.net/2445/224884
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1016/j.thromres.2013.09.019
Thrombosis Research, 2013, vol. 132, num.6, p. 652-658
https://doi.org/10.1016/j.thromres.2013.09.019
dc.rights.none.fl_str_mv (c) Elsevier Ltd., 2013
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Elsevier Ltd., 2013
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 22 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ltd.
publisher.none.fl_str_mv Elsevier Ltd.
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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