An Early Th1 Response Is a Key Factor for a Favorable COVID-19 Evolution

Gil Etayo, Francisco Javier; Garcinuño, Sara; Utrero Rico, Alberto; Cabrera Marante, Oscar; Arroyo Sánchez, Daniel; Mancebo, Esther; Pleguezuelo, Daniel Enrique; Rodríguez Frías, Edgard; Allende Martínez, Luis Miguel; Morales Pérez, Pablo; Castro Panete, María José; Lalueza Blanco, Antonio; Lumbreras Bermejo, Carlos Juan; Paz Artal, Estela Natividad; Serrano, Antonio

An Early Th1 Response Is a Key Factor for a Favorable COVID-19 Evolution

The Th1/Th2 balance plays a crucial role in the progression of different pathologies and is a determining factor in the evolution of infectious diseases. This work has aimed to evaluate the early, or on diagnosis, T-cell compartment response, T-helper subsets and anti-SARS-CoV-2 antibody specificity...

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Detalhes bibliográficos
Autores:	Gil Etayo, Francisco Javier, Garcinuño, Sara, Utrero Rico, Alberto, Cabrera Marante, Oscar, Arroyo Sánchez, Daniel, Mancebo, Esther, Pleguezuelo, Daniel Enrique, Rodríguez Frías, Edgard, Allende Martínez, Luis Miguel, Morales Pérez, Pablo, Castro Panete, María José, Lalueza Blanco, Antonio, Lumbreras Bermejo, Carlos Juan, Paz Artal, Estela Natividad, Serrano, Antonio
Formato:	artículo
Fecha de publicación:	2022
País:	España
Recursos:	Universidad Complutense de Madrid (UCM)
Repositorio:	Docta Complutense
Idioma:	inglés
OAI Identifier:	oai:docta.ucm.es:20.500.14352/71608
Acesso em linha:	https://hdl.handle.net/20.500.14352/71608
Access Level:	acceso abierto
Palavra-chave:	COVID-19 Th1 T helper cell mediated immunity imbalanced immune response Th17 Th2 T-cell subsets SARS-CoV2 Inmunología 2412 Inmunología

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spelling	An Early Th1 Response Is a Key Factor for a Favorable COVID-19 EvolutionGil Etayo, Francisco JavierGarcinuño, SaraUtrero Rico, AlbertoCabrera Marante, OscarArroyo Sánchez, DanielMancebo, EstherPleguezuelo, Daniel EnriqueRodríguez Frías, EdgardAllende Martínez, Luis MiguelMorales Pérez, PabloCastro Panete, María JoséLalueza Blanco, AntonioLumbreras Bermejo, Carlos JuanPaz Artal, Estela NatividadSerrano, AntonioCOVID-19Th1T helpercell mediated immunityimbalanced immune responseTh17Th2T-cell subsetsSARS-CoV2Inmunología2412 InmunologíaThe Th1/Th2 balance plays a crucial role in the progression of different pathologies and is a determining factor in the evolution of infectious diseases. This work has aimed to evaluate the early, or on diagnosis, T-cell compartment response, T-helper subsets and anti-SARS-CoV-2 antibody specificity in COVID-19 patients and to classify them according to evolution based on infection severity. A unicenter, randomized group of 146 COVID-19 patients was divided into four groups in accordance with the most critical events during the course of disease. The immunophenotype and T-helper subsets were analyzed by flow cytometry. Asymptomatic SARS-CoV-2 infected individuals showed a potent and robust Th1 immunity, with a lower Th17 and less activated T-cells at the time of sample acquisition compared not only with symptomatic patients, but also with healthy controls. Conversely, severe COVID-19 patients presented with Th17-skewed immunity, fewer Th1 responses and more activated T-cells. The multivariate analysis of the immunological and inflammatory parameters, together with the comorbidities, showed that the Th1 response was an independent protective factor for the prevention of hospitalization (OR 0.17, 95% CI 0.03–0.81), with an AUC of 0.844. Likewise, the Th1 response was found to be an independent protective factor for severe forms of the disease (OR 0.09, 95% CI: 0.01–0.63, p = 0.015, AUC: 0.873). In conclusion, a predominant Th1 immune response in the acute phase of the SARS-CoV-2 infection could be used as a tool to identify patients who might have a good disease evolution.MPDIUniversidad Complutense de Madrid20222022-01-2720222022-01-27journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/71608reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/716082026-06-02T12:44:21Z
dc.title.none.fl_str_mv	An Early Th1 Response Is a Key Factor for a Favorable COVID-19 Evolution
title	An Early Th1 Response Is a Key Factor for a Favorable COVID-19 Evolution
spellingShingle	An Early Th1 Response Is a Key Factor for a Favorable COVID-19 Evolution Gil Etayo, Francisco Javier COVID-19 Th1 T helper cell mediated immunity imbalanced immune response Th17 Th2 T-cell subsets SARS-CoV2 Inmunología 2412 Inmunología
title_short	An Early Th1 Response Is a Key Factor for a Favorable COVID-19 Evolution
title_full	An Early Th1 Response Is a Key Factor for a Favorable COVID-19 Evolution
title_fullStr	An Early Th1 Response Is a Key Factor for a Favorable COVID-19 Evolution
title_full_unstemmed	An Early Th1 Response Is a Key Factor for a Favorable COVID-19 Evolution
title_sort	An Early Th1 Response Is a Key Factor for a Favorable COVID-19 Evolution
dc.creator.none.fl_str_mv	Gil Etayo, Francisco Javier Garcinuño, Sara Utrero Rico, Alberto Cabrera Marante, Oscar Arroyo Sánchez, Daniel Mancebo, Esther Pleguezuelo, Daniel Enrique Rodríguez Frías, Edgard Allende Martínez, Luis Miguel Morales Pérez, Pablo Castro Panete, María José Lalueza Blanco, Antonio Lumbreras Bermejo, Carlos Juan Paz Artal, Estela Natividad Serrano, Antonio
author	Gil Etayo, Francisco Javier
author_facet	Gil Etayo, Francisco Javier Garcinuño, Sara Utrero Rico, Alberto Cabrera Marante, Oscar Arroyo Sánchez, Daniel Mancebo, Esther Pleguezuelo, Daniel Enrique Rodríguez Frías, Edgard Allende Martínez, Luis Miguel Morales Pérez, Pablo Castro Panete, María José Lalueza Blanco, Antonio Lumbreras Bermejo, Carlos Juan Paz Artal, Estela Natividad Serrano, Antonio
author_role	author
author2	Garcinuño, Sara Utrero Rico, Alberto Cabrera Marante, Oscar Arroyo Sánchez, Daniel Mancebo, Esther Pleguezuelo, Daniel Enrique Rodríguez Frías, Edgard Allende Martínez, Luis Miguel Morales Pérez, Pablo Castro Panete, María José Lalueza Blanco, Antonio Lumbreras Bermejo, Carlos Juan Paz Artal, Estela Natividad Serrano, Antonio
author2_role	author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Universidad Complutense de Madrid
dc.subject.none.fl_str_mv	COVID-19 Th1 T helper cell mediated immunity imbalanced immune response Th17 Th2 T-cell subsets SARS-CoV2 Inmunología 2412 Inmunología
topic	COVID-19 Th1 T helper cell mediated immunity imbalanced immune response Th17 Th2 T-cell subsets SARS-CoV2 Inmunología 2412 Inmunología
description	The Th1/Th2 balance plays a crucial role in the progression of different pathologies and is a determining factor in the evolution of infectious diseases. This work has aimed to evaluate the early, or on diagnosis, T-cell compartment response, T-helper subsets and anti-SARS-CoV-2 antibody specificity in COVID-19 patients and to classify them according to evolution based on infection severity. A unicenter, randomized group of 146 COVID-19 patients was divided into four groups in accordance with the most critical events during the course of disease. The immunophenotype and T-helper subsets were analyzed by flow cytometry. Asymptomatic SARS-CoV-2 infected individuals showed a potent and robust Th1 immunity, with a lower Th17 and less activated T-cells at the time of sample acquisition compared not only with symptomatic patients, but also with healthy controls. Conversely, severe COVID-19 patients presented with Th17-skewed immunity, fewer Th1 responses and more activated T-cells. The multivariate analysis of the immunological and inflammatory parameters, together with the comorbidities, showed that the Th1 response was an independent protective factor for the prevention of hospitalization (OR 0.17, 95% CI 0.03–0.81), with an AUC of 0.844. Likewise, the Th1 response was found to be an independent protective factor for severe forms of the disease (OR 0.09, 95% CI: 0.01–0.63, p = 0.015, AUC: 0.873). In conclusion, a predominant Th1 immune response in the acute phase of the SARS-CoV-2 infection could be used as a tool to identify patients who might have a good disease evolution.
publishDate	2022
dc.date.none.fl_str_mv	2022 2022-01-27 2022 2022-01-27
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/20.500.14352/71608
url	https://hdl.handle.net/20.500.14352/71608
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Atribución 3.0 España https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Atribución 3.0 España https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	MPDI
publisher.none.fl_str_mv	MPDI
dc.source.none.fl_str_mv	reponame:Docta Complutense instname:Universidad Complutense de Madrid (UCM)
instname_str	Universidad Complutense de Madrid (UCM)
reponame_str	Docta Complutense
collection	Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,300719

An Early Th1 Response Is a Key Factor for a Favorable COVID-19 Evolution

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