Inhibitory Role of Growth Hormone in the Induction and Progression Phases of Collagen-Induced Arthritis
Evidence indicates an intimate connection between the neuroendocrine and the immune systems. A number of in vitro and in vivo studies have demonstrated growth hormone (GH) involvement in immune regulation. The GH receptor is expressed by several leukocyte subpopulations, and GH modulates immune cell...
| Autores: | , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/13484 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/13484 |
| Access Level: | acceso abierto |
| Palabra clave: | 577.17 616.72-002 577.27 Collagen-induced arthritis Growth hormone Th17/Th1 cells Cytokines Immune regulation Bioquímica (Medicina) Inmunología Reumatología 2412 Inmunología 3205.09 Reumatología |
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Inhibitory Role of Growth Hormone in the Induction and Progression Phases of Collagen-Induced ArthritisVillares, RicardoCriado, GabrielJuarranz Moratilla, YasminaLópez Santalla, MercedesGarcía Cuesta, Eva MaríaRodríguez Frade, José MiguelLeceta Martínez, JavierLucas, PilarPablos Álvarez, José LuisMartínez-A., CarlosGarín, Marina I.Gomáriz, Rosa P.Mellado, Mario577.17616.72-002577.27Collagen-induced arthritisGrowth hormoneTh17/Th1 cellsCytokinesImmune regulationBioquímica (Medicina)InmunologíaReumatología2412 Inmunología3205.09 ReumatologíaEvidence indicates an intimate connection between the neuroendocrine and the immune systems. A number of in vitro and in vivo studies have demonstrated growth hormone (GH) involvement in immune regulation. The GH receptor is expressed by several leukocyte subpopulations, and GH modulates immune cell proliferation and activity. Here, we found that sustained GH expression protected against collagen-induced arthritis (CIA); in GH-transgenic C57BL/6 (GHTg) mice, disease onset was delayed, and its overall severity was decreased. The anti-collagen response was impaired in these mice, as were inflammatory cytokine levels. Compared to control arthritic littermates, immunized GHTg mice showed significantly lower RORγt (retinoic acid receptor-related orphan receptor gamma 2), IL-17, GM-CSF, IL-22, and IFNγ mRNA expression in draining lymph nodes, whereas there were no differences in IL-21, IL-6, or IL-2 mRNA levels. Data thus suggest that Th17/Th1 cell plasticity toward a pathological phenotype is reduced in these mice. Exogenous GH administration in arthritic DBA/1J mice reduced the severity of established CIA as well as the inflammatory environment, which also shows a GH effect on arthritis progression. These results indicate that GH prevents inflammatory joint destruction in CIA. Our findings demonstrate a modulatory GH role in immune system function that contributes to alleviating CIA symptoms and underlines the importance of endocrine regulation of the immune response.Frontiers MediaUniversidad Complutense de Madrid20182018-05-2520182018-05-25journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/13484reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/134842026-06-02T12:44:21Z |
| dc.title.none.fl_str_mv |
Inhibitory Role of Growth Hormone in the Induction and Progression Phases of Collagen-Induced Arthritis |
| title |
Inhibitory Role of Growth Hormone in the Induction and Progression Phases of Collagen-Induced Arthritis |
| spellingShingle |
Inhibitory Role of Growth Hormone in the Induction and Progression Phases of Collagen-Induced Arthritis Villares, Ricardo 577.17 616.72-002 577.27 Collagen-induced arthritis Growth hormone Th17/Th1 cells Cytokines Immune regulation Bioquímica (Medicina) Inmunología Reumatología 2412 Inmunología 3205.09 Reumatología |
| title_short |
Inhibitory Role of Growth Hormone in the Induction and Progression Phases of Collagen-Induced Arthritis |
| title_full |
Inhibitory Role of Growth Hormone in the Induction and Progression Phases of Collagen-Induced Arthritis |
| title_fullStr |
Inhibitory Role of Growth Hormone in the Induction and Progression Phases of Collagen-Induced Arthritis |
| title_full_unstemmed |
Inhibitory Role of Growth Hormone in the Induction and Progression Phases of Collagen-Induced Arthritis |
| title_sort |
Inhibitory Role of Growth Hormone in the Induction and Progression Phases of Collagen-Induced Arthritis |
| dc.creator.none.fl_str_mv |
Villares, Ricardo Criado, Gabriel Juarranz Moratilla, Yasmina López Santalla, Mercedes García Cuesta, Eva María Rodríguez Frade, José Miguel Leceta Martínez, Javier Lucas, Pilar Pablos Álvarez, José Luis Martínez-A., Carlos Garín, Marina I. Gomáriz, Rosa P. Mellado, Mario |
| author |
Villares, Ricardo |
| author_facet |
Villares, Ricardo Criado, Gabriel Juarranz Moratilla, Yasmina López Santalla, Mercedes García Cuesta, Eva María Rodríguez Frade, José Miguel Leceta Martínez, Javier Lucas, Pilar Pablos Álvarez, José Luis Martínez-A., Carlos Garín, Marina I. Gomáriz, Rosa P. Mellado, Mario |
| author_role |
author |
| author2 |
Criado, Gabriel Juarranz Moratilla, Yasmina López Santalla, Mercedes García Cuesta, Eva María Rodríguez Frade, José Miguel Leceta Martínez, Javier Lucas, Pilar Pablos Álvarez, José Luis Martínez-A., Carlos Garín, Marina I. Gomáriz, Rosa P. Mellado, Mario |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidad Complutense de Madrid |
| dc.subject.none.fl_str_mv |
577.17 616.72-002 577.27 Collagen-induced arthritis Growth hormone Th17/Th1 cells Cytokines Immune regulation Bioquímica (Medicina) Inmunología Reumatología 2412 Inmunología 3205.09 Reumatología |
| topic |
577.17 616.72-002 577.27 Collagen-induced arthritis Growth hormone Th17/Th1 cells Cytokines Immune regulation Bioquímica (Medicina) Inmunología Reumatología 2412 Inmunología 3205.09 Reumatología |
| description |
Evidence indicates an intimate connection between the neuroendocrine and the immune systems. A number of in vitro and in vivo studies have demonstrated growth hormone (GH) involvement in immune regulation. The GH receptor is expressed by several leukocyte subpopulations, and GH modulates immune cell proliferation and activity. Here, we found that sustained GH expression protected against collagen-induced arthritis (CIA); in GH-transgenic C57BL/6 (GHTg) mice, disease onset was delayed, and its overall severity was decreased. The anti-collagen response was impaired in these mice, as were inflammatory cytokine levels. Compared to control arthritic littermates, immunized GHTg mice showed significantly lower RORγt (retinoic acid receptor-related orphan receptor gamma 2), IL-17, GM-CSF, IL-22, and IFNγ mRNA expression in draining lymph nodes, whereas there were no differences in IL-21, IL-6, or IL-2 mRNA levels. Data thus suggest that Th17/Th1 cell plasticity toward a pathological phenotype is reduced in these mice. Exogenous GH administration in arthritic DBA/1J mice reduced the severity of established CIA as well as the inflammatory environment, which also shows a GH effect on arthritis progression. These results indicate that GH prevents inflammatory joint destruction in CIA. Our findings demonstrate a modulatory GH role in immune system function that contributes to alleviating CIA symptoms and underlines the importance of endocrine regulation of the immune response. |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018 2018-05-25 2018 2018-05-25 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/20.500.14352/13484 |
| url |
https://hdl.handle.net/20.500.14352/13484 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Atribución 3.0 España https://creativecommons.org/licenses/by/3.0/es/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Atribución 3.0 España https://creativecommons.org/licenses/by/3.0/es/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Frontiers Media |
| publisher.none.fl_str_mv |
Frontiers Media |
| dc.source.none.fl_str_mv |
reponame:Docta Complutense instname:Universidad Complutense de Madrid (UCM) |
| instname_str |
Universidad Complutense de Madrid (UCM) |
| reponame_str |
Docta Complutense |
| collection |
Docta Complutense |
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15,300719 |