Leptin in osteoarthritis and rheumatoid arthritis: player or bystander?

White adipose tissue (WAT) is a specialized tissue whose main function is lipid synthesis and triglyceride storage. It is now considered as an active organ secreting a plethora of hormones and cytokines namely adipokines. Discovered in 1994, leptin has emerged as a key molecule with pleiotropic func...

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Autores: Ait Eldjoudi, Djedjiga, Cordero Barreal, Alfonso, González-Rodriguez, María, Ruiz-Fernández, Clara, Farrag, Yousof, Lago, Francisca, Capuozzo, Maurizio, González-Gay Mantecón, Miguel Ángel, Mera Varela, Antonio, Pino, Jesús, Gualillo, Oreste
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/28633
Acceso en línea:https://hdl.handle.net/10902/28633
Access Level:acceso abierto
Palabra clave:Leptin
Leptin receptor
Rheumatoid arthritis
Osteoarthritis
Inflammation
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spelling Leptin in osteoarthritis and rheumatoid arthritis: player or bystander?Ait Eldjoudi, DjedjigaCordero Barreal, AlfonsoGonzález-Rodriguez, MaríaRuiz-Fernández, ClaraFarrag, YousofLago, FranciscaCapuozzo, MaurizioGonzález-Gay Mantecón, Miguel ÁngelMera Varela, AntonioPino, JesúsGualillo, OresteLeptinLeptin receptorRheumatoid arthritisOsteoarthritisInflammationWhite adipose tissue (WAT) is a specialized tissue whose main function is lipid synthesis and triglyceride storage. It is now considered as an active organ secreting a plethora of hormones and cytokines namely adipokines. Discovered in 1994, leptin has emerged as a key molecule with pleiotropic functions. It is primarily recognized for its role in regulating energy homeostasis and food intake. Currently, further evidence suggests its potent role in reproduction, glucose metabolism, hematopoiesis, and interaction with the immune system. It is implicated in both innate and adaptive immunity, and it is reported to contribute, with other adipokines, in the cross-talking networks involved in the pathogenesis of chronic inflammation and immune-related diseases of the musculoskeletal system such as osteoarthritis (OA) and rheumatoid arthritis (RA). In this review, we summarize the most recent findings concerning the involvement of leptin in immunity and inflammatory responses in OA and RA.O.G. and F.L. are staff personnel (I3SNS stable researchers) of Xunta de Galicia (Servizo Galego de Saude, SERGAS) through a research-staff contract (ISCIII/SERGAS). C.R.F. is a predoctoral research scholar funded by ISCIII and FEDER (Exp.18/00188). M.G.R. is a recipient of a pre-doctoral contract funded by Xunta de Galicia (IN606A-2020/010). A.C.B. is a recipient of a pre-doctoral contract funded by Secretaría de Estado de Universidades, Investigación, Desarrollo e Innovación, Ministerio de Universidades (FPU2018-04165). O.G. and MAGG are members of the RICORS Programme, RD21/0002/0025 via ISCIII and FEDER. F.L. is a member of Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV). The work of O.G. and J.P. (PI17/00409 and PI20/00902), and F.L. (PI18/00821, PI21/01145) is funded by ISCIII and FEDER. O.G. is a beneficiary of a project funded by the Research Executive Agency of the European Union in the framework of MSCA-RISE Action of the H2020 Programme (project number 734899). O.G. is beneficiary of a grant funded by Xunta de Galicia, Conselleriá de Educación, Universidade e Formación Profesional, and Conselleriá de Economia, Emprego e Industria (GAIN), GPC IN607B2019/10.MDPIUniversidad de Cantabria20222022-03-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttps://hdl.handle.net/10902/28633Int J Mol Sci. 2022, 23(5), 2859reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/286332026-06-02T12:39:31Z
dc.title.none.fl_str_mv Leptin in osteoarthritis and rheumatoid arthritis: player or bystander?
title Leptin in osteoarthritis and rheumatoid arthritis: player or bystander?
spellingShingle Leptin in osteoarthritis and rheumatoid arthritis: player or bystander?
Ait Eldjoudi, Djedjiga
Leptin
Leptin receptor
Rheumatoid arthritis
Osteoarthritis
Inflammation
title_short Leptin in osteoarthritis and rheumatoid arthritis: player or bystander?
title_full Leptin in osteoarthritis and rheumatoid arthritis: player or bystander?
title_fullStr Leptin in osteoarthritis and rheumatoid arthritis: player or bystander?
title_full_unstemmed Leptin in osteoarthritis and rheumatoid arthritis: player or bystander?
title_sort Leptin in osteoarthritis and rheumatoid arthritis: player or bystander?
dc.creator.none.fl_str_mv Ait Eldjoudi, Djedjiga
Cordero Barreal, Alfonso
González-Rodriguez, María
Ruiz-Fernández, Clara
Farrag, Yousof
Lago, Francisca
Capuozzo, Maurizio
González-Gay Mantecón, Miguel Ángel
Mera Varela, Antonio
Pino, Jesús
Gualillo, Oreste
author Ait Eldjoudi, Djedjiga
author_facet Ait Eldjoudi, Djedjiga
Cordero Barreal, Alfonso
González-Rodriguez, María
Ruiz-Fernández, Clara
Farrag, Yousof
Lago, Francisca
Capuozzo, Maurizio
González-Gay Mantecón, Miguel Ángel
Mera Varela, Antonio
Pino, Jesús
Gualillo, Oreste
author_role author
author2 Cordero Barreal, Alfonso
González-Rodriguez, María
Ruiz-Fernández, Clara
Farrag, Yousof
Lago, Francisca
Capuozzo, Maurizio
González-Gay Mantecón, Miguel Ángel
Mera Varela, Antonio
Pino, Jesús
Gualillo, Oreste
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
dc.subject.none.fl_str_mv Leptin
Leptin receptor
Rheumatoid arthritis
Osteoarthritis
Inflammation
topic Leptin
Leptin receptor
Rheumatoid arthritis
Osteoarthritis
Inflammation
description White adipose tissue (WAT) is a specialized tissue whose main function is lipid synthesis and triglyceride storage. It is now considered as an active organ secreting a plethora of hormones and cytokines namely adipokines. Discovered in 1994, leptin has emerged as a key molecule with pleiotropic functions. It is primarily recognized for its role in regulating energy homeostasis and food intake. Currently, further evidence suggests its potent role in reproduction, glucose metabolism, hematopoiesis, and interaction with the immune system. It is implicated in both innate and adaptive immunity, and it is reported to contribute, with other adipokines, in the cross-talking networks involved in the pathogenesis of chronic inflammation and immune-related diseases of the musculoskeletal system such as osteoarthritis (OA) and rheumatoid arthritis (RA). In this review, we summarize the most recent findings concerning the involvement of leptin in immunity and inflammatory responses in OA and RA.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-03-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10902/28633
url https://hdl.handle.net/10902/28633
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Int J Mol Sci. 2022, 23(5), 2859
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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