SARS-CoV-2 infection modulates ACE2 function and subsequent inflammatory responses in swabs and plasma of COVID-19 patients

Angiotensin converting enzyme 2 (ACE2) is a host ectopeptidase and the receptor for the SARS-CoV-2 virus, albeit virus-ACE2 interaction goes far beyond viral entry into target cells. Controversial data exists linking viral infection to changes in ACE2 expression and function, which might influence t...

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Detalles Bibliográficos
Autores: Gutiérrez-Chamorro, Lucía, Riveira Muñoz, Eva, Barrios Barrera, Clara, Palau González, Vanesa, Nevot, Maria, Pedreño-López, Sònia, Senserrich, Jordi, Massanella Luna, Marta, 1983-, Clotet, Bonaventura, Cabrera, Cecilia, Mitjà, Oriol, Crespo Barrio, Marta, Pascual Santos, Julio, Riera, Marta, Ballana Guix, Ester
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/53732
Acceso en línea:http://hdl.handle.net/10230/53732
http://dx.doi.org/10.3390/v13091715
Access Level:acceso abierto
Palabra clave:SARS-CoV-2-ACE2
Biomarker
Inflammation
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spelling SARS-CoV-2 infection modulates ACE2 function and subsequent inflammatory responses in swabs and plasma of COVID-19 patientsGutiérrez-Chamorro, LucíaRiveira Muñoz, EvaBarrios Barrera, ClaraPalau González, VanesaNevot, MariaPedreño-López, SòniaSenserrich, JordiMassanella Luna, Marta, 1983-Clotet, BonaventuraCabrera, CeciliaMitjà, OriolCrespo Barrio, MartaPascual Santos, JulioRiera, MartaBallana Guix, EsterSARS-CoV-2-ACE2BiomarkerInflammationAngiotensin converting enzyme 2 (ACE2) is a host ectopeptidase and the receptor for the SARS-CoV-2 virus, albeit virus-ACE2 interaction goes far beyond viral entry into target cells. Controversial data exists linking viral infection to changes in ACE2 expression and function, which might influence the subsequent induction of an inflammatory response. Here, we tested the significance of soluble ACE2 enzymatic activity longitudinally in nasopharyngeal swabs and plasma samples of SARS-CoV-2 infected patients, along with the induction of inflammatory cytokines. Release of soluble functional ACE2 increases upon SARS-CoV-2 infection in swabs and plasma of infected patients, albeit rapidly decreasing during infection course in parallel with ACE2 gene expression. Similarly, SARS-CoV-2 infection also induced the expression of inflammatory cytokines. These changes positively correlated with the viral load. Overall, our results demonstrate the existence of mechanisms by which SARS-CoV-2 modulates ACE2 expression and function, intracellular viral sensing and subsequent inflammatory response, offering new insights into ACE2 dynamics in the human upper respiratory tract and pointing towards soluble ACE2 levels as a putative early biomarker of infection severity.MDPI202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/53732http://dx.doi.org/10.3390/v13091715reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglés© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/537322026-06-12T07:21:37Z
dc.title.none.fl_str_mv SARS-CoV-2 infection modulates ACE2 function and subsequent inflammatory responses in swabs and plasma of COVID-19 patients
title SARS-CoV-2 infection modulates ACE2 function and subsequent inflammatory responses in swabs and plasma of COVID-19 patients
spellingShingle SARS-CoV-2 infection modulates ACE2 function and subsequent inflammatory responses in swabs and plasma of COVID-19 patients
Gutiérrez-Chamorro, Lucía
SARS-CoV-2-ACE2
Biomarker
Inflammation
title_short SARS-CoV-2 infection modulates ACE2 function and subsequent inflammatory responses in swabs and plasma of COVID-19 patients
title_full SARS-CoV-2 infection modulates ACE2 function and subsequent inflammatory responses in swabs and plasma of COVID-19 patients
title_fullStr SARS-CoV-2 infection modulates ACE2 function and subsequent inflammatory responses in swabs and plasma of COVID-19 patients
title_full_unstemmed SARS-CoV-2 infection modulates ACE2 function and subsequent inflammatory responses in swabs and plasma of COVID-19 patients
title_sort SARS-CoV-2 infection modulates ACE2 function and subsequent inflammatory responses in swabs and plasma of COVID-19 patients
dc.creator.none.fl_str_mv Gutiérrez-Chamorro, Lucía
Riveira Muñoz, Eva
Barrios Barrera, Clara
Palau González, Vanesa
Nevot, Maria
Pedreño-López, Sònia
Senserrich, Jordi
Massanella Luna, Marta, 1983-
Clotet, Bonaventura
Cabrera, Cecilia
Mitjà, Oriol
Crespo Barrio, Marta
Pascual Santos, Julio
Riera, Marta
Ballana Guix, Ester
author Gutiérrez-Chamorro, Lucía
author_facet Gutiérrez-Chamorro, Lucía
Riveira Muñoz, Eva
Barrios Barrera, Clara
Palau González, Vanesa
Nevot, Maria
Pedreño-López, Sònia
Senserrich, Jordi
Massanella Luna, Marta, 1983-
Clotet, Bonaventura
Cabrera, Cecilia
Mitjà, Oriol
Crespo Barrio, Marta
Pascual Santos, Julio
Riera, Marta
Ballana Guix, Ester
author_role author
author2 Riveira Muñoz, Eva
Barrios Barrera, Clara
Palau González, Vanesa
Nevot, Maria
Pedreño-López, Sònia
Senserrich, Jordi
Massanella Luna, Marta, 1983-
Clotet, Bonaventura
Cabrera, Cecilia
Mitjà, Oriol
Crespo Barrio, Marta
Pascual Santos, Julio
Riera, Marta
Ballana Guix, Ester
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv SARS-CoV-2-ACE2
Biomarker
Inflammation
topic SARS-CoV-2-ACE2
Biomarker
Inflammation
description Angiotensin converting enzyme 2 (ACE2) is a host ectopeptidase and the receptor for the SARS-CoV-2 virus, albeit virus-ACE2 interaction goes far beyond viral entry into target cells. Controversial data exists linking viral infection to changes in ACE2 expression and function, which might influence the subsequent induction of an inflammatory response. Here, we tested the significance of soluble ACE2 enzymatic activity longitudinally in nasopharyngeal swabs and plasma samples of SARS-CoV-2 infected patients, along with the induction of inflammatory cytokines. Release of soluble functional ACE2 increases upon SARS-CoV-2 infection in swabs and plasma of infected patients, albeit rapidly decreasing during infection course in parallel with ACE2 gene expression. Similarly, SARS-CoV-2 infection also induced the expression of inflammatory cytokines. These changes positively correlated with the viral load. Overall, our results demonstrate the existence of mechanisms by which SARS-CoV-2 modulates ACE2 expression and function, intracellular viral sensing and subsequent inflammatory response, offering new insights into ACE2 dynamics in the human upper respiratory tract and pointing towards soluble ACE2 levels as a putative early biomarker of infection severity.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/53732
http://dx.doi.org/10.3390/v13091715
url http://hdl.handle.net/10230/53732
http://dx.doi.org/10.3390/v13091715
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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