Experimental evidence of symmetry breaking of transition-path times

While thermal rates of state transitions in classical systems have been studied for almost a century, associated transition-path times have only recently received attention. Uphill and downhill transition paths between states at different free energies should be statistically indistinguishable. Here...

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Detalles Bibliográficos
Autores: Gladrow, J., Ribezzi-Crivellari, M., Ritort Farran, Fèlix, Keyser, U.F.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/162499
Acceso en línea:https://hdl.handle.net/2445/162499
Access Level:acceso abierto
Palabra clave:Energia
Col·loides
Moviment brownià
ADN
Energy
Colloids
Brownian movements
DNA
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spelling Experimental evidence of symmetry breaking of transition-path timesGladrow, J.Ribezzi-Crivellari, M.Ritort Farran, FèlixKeyser, U.F.EnergiaCol·loidesMoviment browniàADNEnergyColloidsBrownian movementsDNAWhile thermal rates of state transitions in classical systems have been studied for almost a century, associated transition-path times have only recently received attention. Uphill and downhill transition paths between states at different free energies should be statistically indistinguishable. Here, we systematically investigate transition-path-time symmetry and report evidence of its breakdown on the molecular- and meso-scale out of equilibrium. In automated Brownian dynamics experiments, we establish first-passage-time symmetries of colloids driven by femtoNewton forces in holographically-created optical landscapes confined within microchannels. Conversely, we show that transitions which couple in a path-dependent manner to fluctuating forces exhibit asymmetry. We reproduce this asymmetry in folding transitions of DNA-hairpins driven out of equilibrium and suggest a topological mechanism of symmetry breakdown. Our results are relevant to measurements that capture a single coordinate in a multidimensional free energy landscape, as encountered in electrophysiology and single-molecule fluorescence experiments.Nature Publishing Group2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/162499Articles publicats en revistes (Física de la Matèria Condensada)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1038/s41467-018-07873-9Nature Communications, 2019, vol. 10, p. 55https://doi.org/10.1038/s41467-018-07873-9info:eu-repo/grantAgreement/EC/H2020/647144info:eu-repo/grantAgreement/EC/H2020/674979info:eu-repo/grantAgreement/EC/H2020/749944cc-by (c) Gladrow, J. et al., 2019http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1624992026-05-27T06:46:51Z
dc.title.none.fl_str_mv Experimental evidence of symmetry breaking of transition-path times
title Experimental evidence of symmetry breaking of transition-path times
spellingShingle Experimental evidence of symmetry breaking of transition-path times
Gladrow, J.
Energia
Col·loides
Moviment brownià
ADN
Energy
Colloids
Brownian movements
DNA
title_short Experimental evidence of symmetry breaking of transition-path times
title_full Experimental evidence of symmetry breaking of transition-path times
title_fullStr Experimental evidence of symmetry breaking of transition-path times
title_full_unstemmed Experimental evidence of symmetry breaking of transition-path times
title_sort Experimental evidence of symmetry breaking of transition-path times
dc.creator.none.fl_str_mv Gladrow, J.
Ribezzi-Crivellari, M.
Ritort Farran, Fèlix
Keyser, U.F.
author Gladrow, J.
author_facet Gladrow, J.
Ribezzi-Crivellari, M.
Ritort Farran, Fèlix
Keyser, U.F.
author_role author
author2 Ribezzi-Crivellari, M.
Ritort Farran, Fèlix
Keyser, U.F.
author2_role author
author
author
dc.subject.none.fl_str_mv Energia
Col·loides
Moviment brownià
ADN
Energy
Colloids
Brownian movements
DNA
topic Energia
Col·loides
Moviment brownià
ADN
Energy
Colloids
Brownian movements
DNA
description While thermal rates of state transitions in classical systems have been studied for almost a century, associated transition-path times have only recently received attention. Uphill and downhill transition paths between states at different free energies should be statistically indistinguishable. Here, we systematically investigate transition-path-time symmetry and report evidence of its breakdown on the molecular- and meso-scale out of equilibrium. In automated Brownian dynamics experiments, we establish first-passage-time symmetries of colloids driven by femtoNewton forces in holographically-created optical landscapes confined within microchannels. Conversely, we show that transitions which couple in a path-dependent manner to fluctuating forces exhibit asymmetry. We reproduce this asymmetry in folding transitions of DNA-hairpins driven out of equilibrium and suggest a topological mechanism of symmetry breakdown. Our results are relevant to measurements that capture a single coordinate in a multidimensional free energy landscape, as encountered in electrophysiology and single-molecule fluorescence experiments.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/162499
url https://hdl.handle.net/2445/162499
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/s41467-018-07873-9
Nature Communications, 2019, vol. 10, p. 55
https://doi.org/10.1038/s41467-018-07873-9
info:eu-repo/grantAgreement/EC/H2020/647144
info:eu-repo/grantAgreement/EC/H2020/674979
info:eu-repo/grantAgreement/EC/H2020/749944
dc.rights.none.fl_str_mv cc-by (c) Gladrow, J. et al., 2019
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Gladrow, J. et al., 2019
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Física de la Matèria Condensada)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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