Diastolic Dysfunction and Exercise Capacity in Patients with Metabolic Syndrome and Overweight/Obesity

Background: Left ventricle diastolic dysfunction (LVDD) is a common finding in high risk individuals, its presence being associated with reduced exercise capacity (EC). We assessed the prevalence of LVDD, applying the 2016 guidelines of the American Society of Echocardiography (ASE)/European Associa...

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Autores: Alonso Gómez, Ángel María, Tojal Sierra, Lucas, Fortuny Frau, Elena, Goicolea Güemez, Leire, Aboitiz Uribarri, Ane, Portillo Baquedano, María Puy, Toledo, Estefanía, Schröder, Helmut, Salas Salvadó, Jordi, Arós Borau, Luis Fernando
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/31063
Acceso en línea:http://hdl.handle.net/10810/31063
Access Level:acceso abierto
Palabra clave:diastolic dysfunction
doppler echocardiography
exercise capacity
metabolic syndrome
obesity
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spelling Diastolic Dysfunction and Exercise Capacity in Patients with Metabolic Syndrome and Overweight/ObesityAlonso Gómez, Ángel MaríaTojal Sierra, LucasFortuny Frau, ElenaGoicolea Güemez, LeireAboitiz Uribarri, AnePortillo Baquedano, María PuyToledo, EstefaníaSchröder, HelmutSalas Salvadó, JordiArós Borau, Luis Fernandodiastolic dysfunctiondoppler echocardiographyexercise capacitymetabolic syndromeobesityBackground: Left ventricle diastolic dysfunction (LVDD) is a common finding in high risk individuals, its presence being associated with reduced exercise capacity (EC). We assessed the prevalence of LVDD, applying the 2016 guidelines of the American Society of Echocardiography (ASE)/European Association of Cardiovascular Imaging (EACVI), in a population with overweight/obesity and metabolic syndrome and its association with EC. Methods and results: This was a prospective, cross-sectional study of a cohort of 235 patients (mean age of 65 ± 5 years old and 33% female) without heart disease and an ejection fraction >50% who underwent a complete echocardiographic assessment and cardiopulmonary exercise testing. Individuals meeting three or more criteria of the 2016 ASE/EACVI guidelines are considered to have LVDD, while tests are considered indeterminate in those meeting only two. Overall, 178 (76%) of our patients met one echocardiographic cutoff value for LVDD, 91 (39%) met two and 7 (3%) three or more. Patients meeting three cutoffs values showed a significant reduction in maximal oxygen uptake (16 ± 3 vs. 19.6 ± 5 ml/kg/min, p < .05), unlike those with indeterminate tests. In multiple regression analysis, meeting three cutoffs was associated with number of METS (SS = -2.2, p = .018). In exploratory analysis, using two criteria based on cutoffs different from those proposed in the guidelines, we identified groups with different EC.This work has been funded by the Carlos III Health Institute (Ministry of Economy, Industry and Competitiveness, Spain) through a FIS project coordinated by Dr. Jordi Salas-Salvadó (PI13/01056), by CIBEROBN (Centre for Biomedical Research Network. Physiopathology of Obesity and Nutrition, Spain) and by the European Research Council, European-Union (Advanced Research Grant 2013–2018; 340918) granted to Dr. Miguel A. González-Martínez.Elsevier201920192019info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/31063reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/grantAgreement/MINECO/PI13/01056https://www.sciencedirect.com/science/article/pii/S2352906718301696?via%3Dihub#!info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/3.0/es/© 2018 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Atribución-NoComercial-SinDerivadas 3.0 Españaoai:addi.ehu.eus:10810/310632026-06-18T09:23:17Z
dc.title.none.fl_str_mv Diastolic Dysfunction and Exercise Capacity in Patients with Metabolic Syndrome and Overweight/Obesity
title Diastolic Dysfunction and Exercise Capacity in Patients with Metabolic Syndrome and Overweight/Obesity
spellingShingle Diastolic Dysfunction and Exercise Capacity in Patients with Metabolic Syndrome and Overweight/Obesity
Alonso Gómez, Ángel María
diastolic dysfunction
doppler echocardiography
exercise capacity
metabolic syndrome
obesity
title_short Diastolic Dysfunction and Exercise Capacity in Patients with Metabolic Syndrome and Overweight/Obesity
title_full Diastolic Dysfunction and Exercise Capacity in Patients with Metabolic Syndrome and Overweight/Obesity
title_fullStr Diastolic Dysfunction and Exercise Capacity in Patients with Metabolic Syndrome and Overweight/Obesity
title_full_unstemmed Diastolic Dysfunction and Exercise Capacity in Patients with Metabolic Syndrome and Overweight/Obesity
title_sort Diastolic Dysfunction and Exercise Capacity in Patients with Metabolic Syndrome and Overweight/Obesity
dc.creator.none.fl_str_mv Alonso Gómez, Ángel María
Tojal Sierra, Lucas
Fortuny Frau, Elena
Goicolea Güemez, Leire
Aboitiz Uribarri, Ane
Portillo Baquedano, María Puy
Toledo, Estefanía
Schröder, Helmut
Salas Salvadó, Jordi
Arós Borau, Luis Fernando
author Alonso Gómez, Ángel María
author_facet Alonso Gómez, Ángel María
Tojal Sierra, Lucas
Fortuny Frau, Elena
Goicolea Güemez, Leire
Aboitiz Uribarri, Ane
Portillo Baquedano, María Puy
Toledo, Estefanía
Schröder, Helmut
Salas Salvadó, Jordi
Arós Borau, Luis Fernando
author_role author
author2 Tojal Sierra, Lucas
Fortuny Frau, Elena
Goicolea Güemez, Leire
Aboitiz Uribarri, Ane
Portillo Baquedano, María Puy
Toledo, Estefanía
Schröder, Helmut
Salas Salvadó, Jordi
Arós Borau, Luis Fernando
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv diastolic dysfunction
doppler echocardiography
exercise capacity
metabolic syndrome
obesity
topic diastolic dysfunction
doppler echocardiography
exercise capacity
metabolic syndrome
obesity
description Background: Left ventricle diastolic dysfunction (LVDD) is a common finding in high risk individuals, its presence being associated with reduced exercise capacity (EC). We assessed the prevalence of LVDD, applying the 2016 guidelines of the American Society of Echocardiography (ASE)/European Association of Cardiovascular Imaging (EACVI), in a population with overweight/obesity and metabolic syndrome and its association with EC. Methods and results: This was a prospective, cross-sectional study of a cohort of 235 patients (mean age of 65 ± 5 years old and 33% female) without heart disease and an ejection fraction >50% who underwent a complete echocardiographic assessment and cardiopulmonary exercise testing. Individuals meeting three or more criteria of the 2016 ASE/EACVI guidelines are considered to have LVDD, while tests are considered indeterminate in those meeting only two. Overall, 178 (76%) of our patients met one echocardiographic cutoff value for LVDD, 91 (39%) met two and 7 (3%) three or more. Patients meeting three cutoffs values showed a significant reduction in maximal oxygen uptake (16 ± 3 vs. 19.6 ± 5 ml/kg/min, p < .05), unlike those with indeterminate tests. In multiple regression analysis, meeting three cutoffs was associated with number of METS (SS = -2.2, p = .018). In exploratory analysis, using two criteria based on cutoffs different from those proposed in the guidelines, we identified groups with different EC.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/31063
url http://hdl.handle.net/10810/31063
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MINECO/PI13/01056
https://www.sciencedirect.com/science/article/pii/S2352906718301696?via%3Dihub#!
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
Atribución-NoComercial-SinDerivadas 3.0 España
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/3.0/es/
Atribución-NoComercial-SinDerivadas 3.0 España
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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