Click chemistry: an efficient toolbox for the design of chitosand-based hydrogels for biomedicine

312 p.

Detalles Bibliográficos
Autor: Guaresti Larrea, Olatz
Tipo de recurso: tesis doctoral
Fecha de publicación:2020
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/50313
Acceso en línea:http://hdl.handle.net/10810/50313
Access Level:acceso abierto
Palabra clave:networks polymers
polymer analysis
polysaccharides
polímeros de redes
análisis de polímeros
polisacáridos
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spelling Click chemistry: an efficient toolbox for the design of chitosand-based hydrogels for biomedicineGuaresti Larrea, Olatznetworks polymerspolymer analysispolysaccharidespolímeros de redesanálisis de polímerospolisacáridos312 p.The present thesis was focused on the development of new gel-type biomaterials form chitosan withexcellent stimuli-responsive properties using different click reactions. To this end, in the first place,chitosan was endowed with specific functionalities, after the controlled insertion of furan, maleimide,thiol or tetrazole groups in the main chain of the biopolymer, maintaining its original biocompatiblecharacter. Hereafter, hydrogels with different size and chemical structure were synthesized by means ofclick type cross-linking reactions (Diels-Alder, thiol-Michael addition or nitrile imine-mediated tetrazoleenecycloaddition). The final physico-chemical, swelling, viscoelastic and morphological properties ofthe different hydrogel systems were studied. So that the new developed biomaterials would be competentin the biomedical field, biodegradability studies under specific enzymes, controlled drug release assays,mucoadhesion experiments with mucin, antibacterial studies against Escherichia coli and Staphylococcusaureus and short-term cytotoxicity assays were conducted, depending on the intended final application.GMT :Materials Technologies Research GroupEceiza Mendiguren, María AranzazuGabilondo López, Nagore2021202120202020info:eu-repo/semantics/doctoralThesisapplication/pdfhttp://hdl.handle.net/10810/50313reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/semantics/openAccess(c)2020 OLATZ GUARESTI LARREAoai:addi.ehu.eus:10810/503132026-06-18T09:23:17Z
dc.title.none.fl_str_mv Click chemistry: an efficient toolbox for the design of chitosand-based hydrogels for biomedicine
title Click chemistry: an efficient toolbox for the design of chitosand-based hydrogels for biomedicine
spellingShingle Click chemistry: an efficient toolbox for the design of chitosand-based hydrogels for biomedicine
Guaresti Larrea, Olatz
networks polymers
polymer analysis
polysaccharides
polímeros de redes
análisis de polímeros
polisacáridos
title_short Click chemistry: an efficient toolbox for the design of chitosand-based hydrogels for biomedicine
title_full Click chemistry: an efficient toolbox for the design of chitosand-based hydrogels for biomedicine
title_fullStr Click chemistry: an efficient toolbox for the design of chitosand-based hydrogels for biomedicine
title_full_unstemmed Click chemistry: an efficient toolbox for the design of chitosand-based hydrogels for biomedicine
title_sort Click chemistry: an efficient toolbox for the design of chitosand-based hydrogels for biomedicine
dc.creator.none.fl_str_mv Guaresti Larrea, Olatz
author Guaresti Larrea, Olatz
author_facet Guaresti Larrea, Olatz
author_role author
dc.contributor.none.fl_str_mv Eceiza Mendiguren, María Aranzazu
Gabilondo López, Nagore
dc.subject.none.fl_str_mv networks polymers
polymer analysis
polysaccharides
polímeros de redes
análisis de polímeros
polisacáridos
topic networks polymers
polymer analysis
polysaccharides
polímeros de redes
análisis de polímeros
polisacáridos
description 312 p.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/50313
url http://hdl.handle.net/10810/50313
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
(c)2020 OLATZ GUARESTI LARREA
eu_rights_str_mv openAccess
rights_invalid_str_mv (c)2020 OLATZ GUARESTI LARREA
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301629

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