GEMC1 is a critical regulator of multiciliated cell differentiation.

The generation of multiciliated cells (MCCs) is required for the proper function of many tissues, including the respiratory tract, brain, and germline. Defects in MCC development have been demonstrated to cause a subclass of mucociliary clearance disorders termed reduced generation of multiple motil...

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Detalles Bibliográficos
Autores: Terré, Berta, Piergiovanni, Gabriele, Segura-Bayona, Sandra, Gil Gómez, Gabriel, Youssef, Sameh A., Attolini, Camille Stephan-Otto, Wilsch-Bräuninger, Michaela, Jung, Carole, Rojas Mendoza, Ana Maria, Marjanovi c, Marko, Knobel, Philip A., Palenzuela, Lluís, López-Rovira, Teresa, Forrow, Stephen, Huttner, Wieland B., Valverde, M. A. (Miguel Ángel), 1963-, de Bruin, Alain, Costanzo, Vincenzo, Stracker, Travis
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2016
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/26303
Acceso en línea:http://hdl.handle.net/10230/26303
http://dx.doi.org/10.15252/embj.201592821
Access Level:acceso abierto
Palabra clave:Hidrocefàlia
Esterilitat
Descripción
Sumario:The generation of multiciliated cells (MCCs) is required for the proper function of many tissues, including the respiratory tract, brain, and germline. Defects in MCC development have been demonstrated to cause a subclass of mucociliary clearance disorders termed reduced generation of multiple motile cilia (RGMC). To date, only two genes, Multicilin (MCIDAS) and cyclin O (CCNO) have been identified in this disorder in humans.

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