The Interaction between Childhood Bullying and the FKBP5 Gene on Psychotic-Like Experiences and Stress Reactivity in Real Life

Aim: The present study employed Experience Sampling Methodology to examine whether the interaction between childhood bullying and FKBP5 variability (i) is associated with the expression of psychotic-like experiences, paranoia, and negative affect, and (ii) moderates psychotic-like, paranoid, and aff...

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Autores: Cristóbal Narváez, Paula, Sheinbaum, Tamara, Rosa de la Cruz, Araceli, Ballespí, Sergi, Castro Catala, Marta de, Peña Lozano, Elionora, Kwapil, Thomas R., Barrantes Vidal, Neus
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/101634
Acceso en línea:https://hdl.handle.net/2445/101634
Access Level:acceso abierto
Palabra clave:Assetjament psicològic
Infants
Agressivitat
Percepció en els infants
Estrès (Psicologia)
Psychological abuse
Children
Aggressiveness
Perception in children
Stress (Psychology)
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network_acronym_str ES
network_name_str España
repository_id_str
spelling The Interaction between Childhood Bullying and the FKBP5 Gene on Psychotic-Like Experiences and Stress Reactivity in Real LifeCristóbal Narváez, PaulaSheinbaum, TamaraRosa de la Cruz, AraceliBallespí, SergiCastro Catala, Marta dePeña Lozano, ElionoraKwapil, Thomas R.Barrantes Vidal, NeusAssetjament psicològicInfantsAgressivitatPercepció en els infantsEstrès (Psicologia)Psychological abuseChildrenAggressivenessPerception in childrenStress (Psychology)Aim: The present study employed Experience Sampling Methodology to examine whether the interaction between childhood bullying and FKBP5 variability (i) is associated with the expression of psychotic-like experiences, paranoia, and negative affect, and (ii) moderates psychotic-like, paranoid, and affective reactivity to different forms of momentary stress (situational and social) in daily life. Methods: A total of 206 nonclinical young adults were interviewed for bullying with the Childhood Experience of Care and Abuse and were prompted randomly eight times daily for one week to complete assessments of their current experiences, affect, and stress appraisals. Participants were genotyped for three FKBP5 single nucleotide polymorphisms (SNPs) (rs3800373, rs9296158, and rs1360780) that have been linked to hypothalamus-pituitary-adrenal axis reactivity. Multilevel analyses were conducted to examine the effect of the interaction between childhood bullying and the FKBP5 haplotype derived from these three SNPs. Results: The interaction between bullying and the FKBP5 haplotype was associated with positive, but not negative, psychotic-like experiences, paranoia, and negative affect. The bullying x FKBP5 interaction also moderated the association of a social stress appraisal (specifically, being alone because people do not want to be with you) with psychotic-like experiences and negative affect in daily life. Simple slopes analyses indicated that, in all cases, the associations were significantly increased by exposure to bullying in participants with the risk haplotype, but not for those with the non-risk haplotype. Discussion: The present study provides the first evidence of the interplay between childhood bullying and FKBP5 variability in the real-world expression of psychosis proneness and social stress reactivity. The findings underscore the importance of investigating how gene-environment interactions are involved in mechanistic pathways to the extended psychosis phenotype and lend further support to the increasing relevance given to socially defeating appraisals in the experience of reality distortion.Public Library of Science (PLoS)2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/101634Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0158809PLoS One, 2016, vol. 11, num. 7, p. e0158809http://dx.doi.org/10.1371/journal.pone.0158809cc-by (c) Cristóbal Narváez, Paula et al., 2016http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1016342026-05-27T06:46:51Z
dc.title.none.fl_str_mv The Interaction between Childhood Bullying and the FKBP5 Gene on Psychotic-Like Experiences and Stress Reactivity in Real Life
title The Interaction between Childhood Bullying and the FKBP5 Gene on Psychotic-Like Experiences and Stress Reactivity in Real Life
spellingShingle The Interaction between Childhood Bullying and the FKBP5 Gene on Psychotic-Like Experiences and Stress Reactivity in Real Life
Cristóbal Narváez, Paula
Assetjament psicològic
Infants
Agressivitat
Percepció en els infants
Estrès (Psicologia)
Psychological abuse
Children
Aggressiveness
Perception in children
Stress (Psychology)
title_short The Interaction between Childhood Bullying and the FKBP5 Gene on Psychotic-Like Experiences and Stress Reactivity in Real Life
title_full The Interaction between Childhood Bullying and the FKBP5 Gene on Psychotic-Like Experiences and Stress Reactivity in Real Life
title_fullStr The Interaction between Childhood Bullying and the FKBP5 Gene on Psychotic-Like Experiences and Stress Reactivity in Real Life
title_full_unstemmed The Interaction between Childhood Bullying and the FKBP5 Gene on Psychotic-Like Experiences and Stress Reactivity in Real Life
title_sort The Interaction between Childhood Bullying and the FKBP5 Gene on Psychotic-Like Experiences and Stress Reactivity in Real Life
dc.creator.none.fl_str_mv Cristóbal Narváez, Paula
Sheinbaum, Tamara
Rosa de la Cruz, Araceli
Ballespí, Sergi
Castro Catala, Marta de
Peña Lozano, Elionora
Kwapil, Thomas R.
Barrantes Vidal, Neus
author Cristóbal Narváez, Paula
author_facet Cristóbal Narváez, Paula
Sheinbaum, Tamara
Rosa de la Cruz, Araceli
Ballespí, Sergi
Castro Catala, Marta de
Peña Lozano, Elionora
Kwapil, Thomas R.
Barrantes Vidal, Neus
author_role author
author2 Sheinbaum, Tamara
Rosa de la Cruz, Araceli
Ballespí, Sergi
Castro Catala, Marta de
Peña Lozano, Elionora
Kwapil, Thomas R.
Barrantes Vidal, Neus
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Assetjament psicològic
Infants
Agressivitat
Percepció en els infants
Estrès (Psicologia)
Psychological abuse
Children
Aggressiveness
Perception in children
Stress (Psychology)
topic Assetjament psicològic
Infants
Agressivitat
Percepció en els infants
Estrès (Psicologia)
Psychological abuse
Children
Aggressiveness
Perception in children
Stress (Psychology)
description Aim: The present study employed Experience Sampling Methodology to examine whether the interaction between childhood bullying and FKBP5 variability (i) is associated with the expression of psychotic-like experiences, paranoia, and negative affect, and (ii) moderates psychotic-like, paranoid, and affective reactivity to different forms of momentary stress (situational and social) in daily life. Methods: A total of 206 nonclinical young adults were interviewed for bullying with the Childhood Experience of Care and Abuse and were prompted randomly eight times daily for one week to complete assessments of their current experiences, affect, and stress appraisals. Participants were genotyped for three FKBP5 single nucleotide polymorphisms (SNPs) (rs3800373, rs9296158, and rs1360780) that have been linked to hypothalamus-pituitary-adrenal axis reactivity. Multilevel analyses were conducted to examine the effect of the interaction between childhood bullying and the FKBP5 haplotype derived from these three SNPs. Results: The interaction between bullying and the FKBP5 haplotype was associated with positive, but not negative, psychotic-like experiences, paranoia, and negative affect. The bullying x FKBP5 interaction also moderated the association of a social stress appraisal (specifically, being alone because people do not want to be with you) with psychotic-like experiences and negative affect in daily life. Simple slopes analyses indicated that, in all cases, the associations were significantly increased by exposure to bullying in participants with the risk haplotype, but not for those with the non-risk haplotype. Discussion: The present study provides the first evidence of the interplay between childhood bullying and FKBP5 variability in the real-world expression of psychosis proneness and social stress reactivity. The findings underscore the importance of investigating how gene-environment interactions are involved in mechanistic pathways to the extended psychosis phenotype and lend further support to the increasing relevance given to socially defeating appraisals in the experience of reality distortion.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/101634
url https://hdl.handle.net/2445/101634
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0158809
PLoS One, 2016, vol. 11, num. 7, p. e0158809
http://dx.doi.org/10.1371/journal.pone.0158809
dc.rights.none.fl_str_mv cc-by (c) Cristóbal Narváez, Paula et al., 2016
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Cristóbal Narváez, Paula et al., 2016
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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