Investigating the regulatory immune response and the impact of COVID-19 lockdown on lifestyle habits considering the level of disease progression in patients with type 2 diabetes mellitus.
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and pancreatic beta-cell dysfunction as the pathology progresses to more advanced stages. This condition is highly heterogeneous in terms of clinical characteristics, nutritional and pharmacological m...
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| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/130799 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/130799 |
| Access Level: | acceso abierto |
| Palabra clave: | 616.379-008.64(043.2) Diabetes Medicina 32 Ciencias Médicas |
| Sumario: | Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and pancreatic beta-cell dysfunction as the pathology progresses to more advanced stages. This condition is highly heterogeneous in terms of clinical characteristics, nutritional and pharmacological management, and risk of complications. Additionally, T2DM is associated with numerous comorbilities, including cardiovascular diseases, diabetic dyslipidemia, hypertension, and metabolic-dysfunction associated steatotic liver disease (MASLD). T2DM is closely linked to the immune system both causally and consequently, with abnormal activation of immune cells and a chronic inflammatory environment playing a crucial role in its progression. The COVID-19 pandemic has further exacerbated these challenges, causing significant lifestyle changes and affecting the metabolic control of patients with T2DM... |
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