The early-life exposome modulates the effect of polymorphic inversions on DNA methylation

Polymorphic genomic inversions are chromosomal variants with intrinsic variability that play important roles in evolution, environmental adaptation, and complex traits. We investigated the DNA methylation patterns of three common human inversions, at 8p23.1, 16p11.2, and 17q21.31 in 1,009 blood samp...

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Detalles Bibliográficos
Autores: Carreras Gallo, Natàlia, Cáceres Domínguez, Alejandro, Balagué Dobón, Laura, Ruiz-Arenas, Carlos, Andrusaityte, Sandra, Carracedo, Ángel, Casas, Maribel, Chatzi, Leda, Grazuleviciene, Regina, Gutzkow, Kristine Bjerve, Lepeule, Johanna, Maitre, Léa, Nieuwenhuijsen, Mark J, Slama, Remy, Stratakis, Nikos
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/379244
Acceso en línea:https://hdl.handle.net/2117/379244
https://dx.doi.org/10.1038/s42003-022-03380-2
Access Level:acceso abierto
Palabra clave:DNA--Analysis
ADN--Anàlisi
Àrees temàtiques de la UPC::Matemàtiques i estadística
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spelling The early-life exposome modulates the effect of polymorphic inversions on DNA methylationCarreras Gallo, NatàliaCáceres Domínguez, AlejandroBalagué Dobón, LauraRuiz-Arenas, CarlosAndrusaityte, SandraCarracedo, ÁngelCasas, MaribelChatzi, LedaGrazuleviciene, ReginaGutzkow, Kristine BjerveLepeule, JohannaMaitre, LéaNieuwenhuijsen, Mark JSlama, RemyStratakis, NikosDNA--AnalysisADN--AnàlisiÀrees temàtiques de la UPC::Matemàtiques i estadísticaPolymorphic genomic inversions are chromosomal variants with intrinsic variability that play important roles in evolution, environmental adaptation, and complex traits. We investigated the DNA methylation patterns of three common human inversions, at 8p23.1, 16p11.2, and 17q21.31 in 1,009 blood samples from children from the Human Early Life Exposome (HELIX) project and in 39 prenatal heart tissue samples. We found inversion-state specific methylation patterns within and nearby flanking each inversion region in both datasets. Additionally, numerous inversion-exposure interactions on methylation levels were identified from early-life exposome data comprising 64 exposures. For instance, children homozygous at inv-8p23.1 and higher meat intake were more susceptible to TDH hypermethylation (P¿=¿3.8¿×¿10-22); being the inversion, exposure, and gene known risk factors for adult obesity. Inv-8p23.1 associated hypermethylation of GATA4 was also detected across numerous exposures. Our data suggests that the pleiotropic influence of inversions during development and lifetime could be substantially mediated by allele-specific methylation patterns which can be modulated by the exposome.Peer ReviewedSpringer Nature20222022-05-1220222022-12-22journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/379244https://dx.doi.org/10.1038/s42003-022-03380-2reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/3792442026-05-27T15:37:01Z
dc.title.none.fl_str_mv The early-life exposome modulates the effect of polymorphic inversions on DNA methylation
title The early-life exposome modulates the effect of polymorphic inversions on DNA methylation
spellingShingle The early-life exposome modulates the effect of polymorphic inversions on DNA methylation
Carreras Gallo, Natàlia
DNA--Analysis
ADN--Anàlisi
Àrees temàtiques de la UPC::Matemàtiques i estadística
title_short The early-life exposome modulates the effect of polymorphic inversions on DNA methylation
title_full The early-life exposome modulates the effect of polymorphic inversions on DNA methylation
title_fullStr The early-life exposome modulates the effect of polymorphic inversions on DNA methylation
title_full_unstemmed The early-life exposome modulates the effect of polymorphic inversions on DNA methylation
title_sort The early-life exposome modulates the effect of polymorphic inversions on DNA methylation
dc.creator.none.fl_str_mv Carreras Gallo, Natàlia
Cáceres Domínguez, Alejandro
Balagué Dobón, Laura
Ruiz-Arenas, Carlos
Andrusaityte, Sandra
Carracedo, Ángel
Casas, Maribel
Chatzi, Leda
Grazuleviciene, Regina
Gutzkow, Kristine Bjerve
Lepeule, Johanna
Maitre, Léa
Nieuwenhuijsen, Mark J
Slama, Remy
Stratakis, Nikos
author Carreras Gallo, Natàlia
author_facet Carreras Gallo, Natàlia
Cáceres Domínguez, Alejandro
Balagué Dobón, Laura
Ruiz-Arenas, Carlos
Andrusaityte, Sandra
Carracedo, Ángel
Casas, Maribel
Chatzi, Leda
Grazuleviciene, Regina
Gutzkow, Kristine Bjerve
Lepeule, Johanna
Maitre, Léa
Nieuwenhuijsen, Mark J
Slama, Remy
Stratakis, Nikos
author_role author
author2 Cáceres Domínguez, Alejandro
Balagué Dobón, Laura
Ruiz-Arenas, Carlos
Andrusaityte, Sandra
Carracedo, Ángel
Casas, Maribel
Chatzi, Leda
Grazuleviciene, Regina
Gutzkow, Kristine Bjerve
Lepeule, Johanna
Maitre, Léa
Nieuwenhuijsen, Mark J
Slama, Remy
Stratakis, Nikos
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv DNA--Analysis
ADN--Anàlisi
Àrees temàtiques de la UPC::Matemàtiques i estadística
topic DNA--Analysis
ADN--Anàlisi
Àrees temàtiques de la UPC::Matemàtiques i estadística
description Polymorphic genomic inversions are chromosomal variants with intrinsic variability that play important roles in evolution, environmental adaptation, and complex traits. We investigated the DNA methylation patterns of three common human inversions, at 8p23.1, 16p11.2, and 17q21.31 in 1,009 blood samples from children from the Human Early Life Exposome (HELIX) project and in 39 prenatal heart tissue samples. We found inversion-state specific methylation patterns within and nearby flanking each inversion region in both datasets. Additionally, numerous inversion-exposure interactions on methylation levels were identified from early-life exposome data comprising 64 exposures. For instance, children homozygous at inv-8p23.1 and higher meat intake were more susceptible to TDH hypermethylation (P¿=¿3.8¿×¿10-22); being the inversion, exposure, and gene known risk factors for adult obesity. Inv-8p23.1 associated hypermethylation of GATA4 was also detected across numerous exposures. Our data suggests that the pleiotropic influence of inversions during development and lifetime could be substantially mediated by allele-specific methylation patterns which can be modulated by the exposome.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-05-12
2022
2022-12-22
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/379244
https://dx.doi.org/10.1038/s42003-022-03380-2
url https://hdl.handle.net/2117/379244
https://dx.doi.org/10.1038/s42003-022-03380-2
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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