The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome.

Selma, María Victoria; González-Sarrías, Antonio; Salas Salvadó, Jordi; Andrés Lacueva, Ma. Cristina; Alasalvar, Cesarettin; Örem, Asim; Tomas-Barberan, F. A. (Francisco A.); Espín, Juan Carlos

The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome.

Background & aims: Urolithins are microbial metabolites produced after consumption of ellagitannincontaining foods such as pomegranates and walnuts. Parallel to isoflavone-metabolizing phenotypes, ellagitannin-metabolizing phenotypes (urolithin metabotypes A, B and 0; UM-A, UM-B and UM-0, respec...

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Authors:	Selma, María Victoria, González-Sarrías, Antonio, Salas Salvadó, Jordi, Andrés Lacueva, Ma. Cristina, Alasalvar, Cesarettin, Örem, Asim, Tomas-Barberan, F. A. (Francisco A.), Espín, Juan Carlos
Format:	article
Status:	Versión aceptada para publicación
Publication Date:	2017
Country:	España
Institution:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/163670
Online Access:	https://hdl.handle.net/2445/163670
Access Level:	Open access
Keyword:	Metabolisme Microbiota intestinal Obesitat Marcadors bioquímics Malalties cardiovasculars Fruita seca Magranes Fisiologia Polifenols Lípids Metabolism Gastrointestinal microbiome Obesity Biochemical markers Cardiovascular diseases Dried fruit Pomegranate (Fruit) Physiology Polyphenols Lipids

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repository_id_str
spelling	The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome.Selma, María VictoriaGonzález-Sarrías, AntonioSalas Salvadó, JordiAndrés Lacueva, Ma. CristinaAlasalvar, CesarettinÖrem, AsimTomas-Barberan, F. A. (Francisco A.)Espín, Juan CarlosMetabolismeMicrobiota intestinalObesitatMarcadors bioquímicsMalalties cardiovascularsFruita secaMagranesFisiologiaPolifenolsLípidsMetabolismGastrointestinal microbiomeObesityBiochemical markersCardiovascular diseasesDried fruitPomegranate (Fruit)PhysiologyPolyphenolsLipidsBackground & aims: Urolithins are microbial metabolites produced after consumption of ellagitannincontaining foods such as pomegranates and walnuts. Parallel to isoflavone-metabolizing phenotypes, ellagitannin-metabolizing phenotypes (urolithin metabotypes A, B and 0; UM-A, UM-B and UM-0, respectively) can vary among individuals depending on their body mass index (BMI), but correlations between urolithin metabotypes (UMs) and cardiometabolic risk (CMR) factors are unexplored. We investigated the association between UMs and CMR factors in individuals with different BMI and health status. Methods: UM was identified using UPLC-ESI-qToF-MS in individuals consuming pomegranate or nuts. The associations between basal CMR factors and the urine urolithin metabolomic signature were explored in 20 healthy normoweight individuals consuming walnuts (30 g/d), 49 healthy overweightobese individuals ingesting pomegranate extract (450 mg/d) and 25 metabolic syndrome (MetS) patients consuming nuts (15 g-walnuts, 7.5 g-hazelnuts and 7.5 g-almonds/d). Results: Correlations between CMR factors and urolithins were found in overweight-obese individuals. Urolithin-A (mostly present in UM-A) was positively correlated with apolipoprotein A-I (P 0.05) and intermediate-HDL-cholesterol (P 0.05) while urolithin-B and isourolithin-A (characteristic from UM-B) were positively correlated with total-cholesterol, LDL-cholesterol (P 0.001), apolipoprotein B (P 0.01), VLDL-cholesterol, IDL-cholesterol, oxidized-LDL and apolipoprotein B:apolipoprotein A-I ratio (P 0.05). In MetS patients, urolithin-A only correlated inversely with glucose (P 0.05). Statin-treated MetS patients with UM-A showed a lipid profile similar to that of healthy normoweight individuals while a poor response to lipid-lowering therapy was observed in MB patients. Conclusions: UMs are potential CMR biomarkers. Overweight-obese individuals with UM-B are at increased risk of cardiometabolic disease, whereas urolithin-A production could protect against CMR factors. Further research is warranted to explore these associations in larger cohorts and whether the effect of lipidlowering drugs or ellagitannin-consumption on CMR biomarkers depends on individuals' UM.Elsevier2020202020172020info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion9 p.application/pdfhttps://hdl.handle.net/2445/163670Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1016/j.clnu.2017.03.012Clinical Nutrition, 2017, vol. 37, num. 3, p. 897-905https://doi.org/10.1016/j.clnu.2017.03.012info:eu-repo/grantAgreement/EC/H2020/951994cc-by-nc-nd (c) Elsevier Ltd and European Society for Clinical Nutrition and Metabolism, 2017http://creativecommons.org/licenses/by-nc-nd/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1636702026-05-29T05:05:01Z
dc.title.none.fl_str_mv	The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome.
title	The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome.
spellingShingle	The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome. Selma, María Victoria Metabolisme Microbiota intestinal Obesitat Marcadors bioquímics Malalties cardiovasculars Fruita seca Magranes Fisiologia Polifenols Lípids Metabolism Gastrointestinal microbiome Obesity Biochemical markers Cardiovascular diseases Dried fruit Pomegranate (Fruit) Physiology Polyphenols Lipids
title_short	The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome.
title_full	The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome.
title_fullStr	The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome.
title_full_unstemmed	The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome.
title_sort	The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome.
dc.creator.none.fl_str_mv	Selma, María Victoria González-Sarrías, Antonio Salas Salvadó, Jordi Andrés Lacueva, Ma. Cristina Alasalvar, Cesarettin Örem, Asim Tomas-Barberan, F. A. (Francisco A.) Espín, Juan Carlos
author	Selma, María Victoria
author_facet	Selma, María Victoria González-Sarrías, Antonio Salas Salvadó, Jordi Andrés Lacueva, Ma. Cristina Alasalvar, Cesarettin Örem, Asim Tomas-Barberan, F. A. (Francisco A.) Espín, Juan Carlos
author_role	author
author2	González-Sarrías, Antonio Salas Salvadó, Jordi Andrés Lacueva, Ma. Cristina Alasalvar, Cesarettin Örem, Asim Tomas-Barberan, F. A. (Francisco A.) Espín, Juan Carlos
author2_role	author author author author author author author
dc.subject.none.fl_str_mv	Metabolisme Microbiota intestinal Obesitat Marcadors bioquímics Malalties cardiovasculars Fruita seca Magranes Fisiologia Polifenols Lípids Metabolism Gastrointestinal microbiome Obesity Biochemical markers Cardiovascular diseases Dried fruit Pomegranate (Fruit) Physiology Polyphenols Lipids
topic	Metabolisme Microbiota intestinal Obesitat Marcadors bioquímics Malalties cardiovasculars Fruita seca Magranes Fisiologia Polifenols Lípids Metabolism Gastrointestinal microbiome Obesity Biochemical markers Cardiovascular diseases Dried fruit Pomegranate (Fruit) Physiology Polyphenols Lipids
description	Background & aims: Urolithins are microbial metabolites produced after consumption of ellagitannincontaining foods such as pomegranates and walnuts. Parallel to isoflavone-metabolizing phenotypes, ellagitannin-metabolizing phenotypes (urolithin metabotypes A, B and 0; UM-A, UM-B and UM-0, respectively) can vary among individuals depending on their body mass index (BMI), but correlations between urolithin metabotypes (UMs) and cardiometabolic risk (CMR) factors are unexplored. We investigated the association between UMs and CMR factors in individuals with different BMI and health status. Methods: UM was identified using UPLC-ESI-qToF-MS in individuals consuming pomegranate or nuts. The associations between basal CMR factors and the urine urolithin metabolomic signature were explored in 20 healthy normoweight individuals consuming walnuts (30 g/d), 49 healthy overweightobese individuals ingesting pomegranate extract (450 mg/d) and 25 metabolic syndrome (MetS) patients consuming nuts (15 g-walnuts, 7.5 g-hazelnuts and 7.5 g-almonds/d). Results: Correlations between CMR factors and urolithins were found in overweight-obese individuals. Urolithin-A (mostly present in UM-A) was positively correlated with apolipoprotein A-I (P 0.05) and intermediate-HDL-cholesterol (P 0.05) while urolithin-B and isourolithin-A (characteristic from UM-B) were positively correlated with total-cholesterol, LDL-cholesterol (P 0.001), apolipoprotein B (P 0.01), VLDL-cholesterol, IDL-cholesterol, oxidized-LDL and apolipoprotein B:apolipoprotein A-I ratio (P 0.05). In MetS patients, urolithin-A only correlated inversely with glucose (P 0.05). Statin-treated MetS patients with UM-A showed a lipid profile similar to that of healthy normoweight individuals while a poor response to lipid-lowering therapy was observed in MB patients. Conclusions: UMs are potential CMR biomarkers. Overweight-obese individuals with UM-B are at increased risk of cardiometabolic disease, whereas urolithin-A production could protect against CMR factors. Further research is warranted to explore these associations in larger cohorts and whether the effect of lipidlowering drugs or ellagitannin-consumption on CMR biomarkers depends on individuals' UM.
publishDate	2017
dc.date.none.fl_str_mv	2017 2020 2020 2020
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion
format	article
status_str	acceptedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/163670
url	https://hdl.handle.net/2445/163670
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Versió postprint del document publicat a: https://doi.org/10.1016/j.clnu.2017.03.012 Clinical Nutrition, 2017, vol. 37, num. 3, p. 897-905 https://doi.org/10.1016/j.clnu.2017.03.012 info:eu-repo/grantAgreement/EC/H2020/951994
dc.rights.none.fl_str_mv	cc-by-nc-nd (c) Elsevier Ltd and European Society for Clinical Nutrition and Metabolism, 2017 http://creativecommons.org/licenses/by-nc-nd/3.0/es info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc-by-nc-nd (c) Elsevier Ltd and European Society for Clinical Nutrition and Metabolism, 2017 http://creativecommons.org/licenses/by-nc-nd/3.0/es
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	9 p. application/pdf
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,812429

The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome.

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