Genetic Differences in Reactivity to the Environment Impact Psychotic-Like and Affective Reactivity in Daily Life

Consistent with diathesis-stress models, psychosis research has focused on genetic moderation of adverse environmental exposures. In contrast, the Differential Susceptibility (DS) model suggests that the same genetic variants that increase risk-inducing effects of adverse experiences also enhance be...

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Autores: Barrantes Vidal, Neus|||0000-0002-8671-1238, Torrecilla González, Pilar|||0000-0003-2017-6014, Mas-Bermejo, Patricia|||0000-0003-4789-9650, Papiol, Sergi|||0000-0001-9366-8728, Bakermans-Kranenburg, Marian|||0000-0001-7763-0711, Rosa de la Cruz, Araceli|||0000-0001-6935-3785, Kwapil, Thomas|||0000-0003-1116-5954
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:320999
Acceso en línea:https://ddd.uab.cat/record/320999
https://dx.doi.org/urn:doi:10.1093/schbul/sbad162
Access Level:acceso abierto
Palabra clave:Schizotypy
Psychosis
Gene-environment interaction
Experience sampling methodology
Differential susceptibility
Polygenic Risk Score
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spelling Genetic Differences in Reactivity to the Environment Impact Psychotic-Like and Affective Reactivity in Daily LifeBarrantes Vidal, Neus|||0000-0002-8671-1238Torrecilla González, Pilar|||0000-0003-2017-6014Mas-Bermejo, Patricia|||0000-0003-4789-9650Papiol, Sergi|||0000-0001-9366-8728Bakermans-Kranenburg, Marian|||0000-0001-7763-0711Rosa de la Cruz, Araceli|||0000-0001-6935-3785Kwapil, Thomas|||0000-0003-1116-5954SchizotypyPsychosisGene-environment interactionExperience sampling methodologyDifferential susceptibilityPolygenic Risk ScoreConsistent with diathesis-stress models, psychosis research has focused on genetic moderation of adverse environmental exposures. In contrast, the Differential Susceptibility (DS) model suggests that the same genetic variants that increase risk-inducing effects of adverse experiences also enhance beneficial effects from positive experiences. This study examined whether individuals with high genetic susceptibility to the environment showed differential psychotic-like and affective reactivity in response to positive and negative events in daily life. Experience sampling methodology assessed context (positive and stressful) and momentary levels of paranoia, psychotic-like experiences (PLE), and positive (PA) and negative affect (NA) in 217 non-clinical adults oversampled for schizotypy. Linear mixed models examined whether Polygenic Risk Scores of Environmental Sensitivity (PRS-ES) moderated the impact of current context on subsequent experiences. PRS-ES moderated positive, but not stressful, context on subsequent levels of momentary paranoia, NA, and PA, but not PLE. Genetic and environmental (G × E) interactions indicated diathesis-stress at lower thresholds of PRS-ES, but a DS model at the highest threshold of the PRS-ES. Participants with elevated PRS-ES showed increased paranoia and NA and decreased PA in subsequent assessments when reporting low levels of positive situations, but also decreased paranoia and NA and increased PA when rating contexts as positive. Findings support the influence of genetic sensitivity to the environment on psychotic-like and affective reactivity in daily life, particularly in response to positive contexts. This highlights the transdiagnostic protective role of positive experiences and informs ecological momentary interventions. 22025-01-0120252025-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/320999https://dx.doi.org/urn:doi:10.1093/schbul/sbad162reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 PSI2017-91814-EXPAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-119211RB-I00Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-01010open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3209992026-06-06T12:50:31Z
dc.title.none.fl_str_mv Genetic Differences in Reactivity to the Environment Impact Psychotic-Like and Affective Reactivity in Daily Life
title Genetic Differences in Reactivity to the Environment Impact Psychotic-Like and Affective Reactivity in Daily Life
spellingShingle Genetic Differences in Reactivity to the Environment Impact Psychotic-Like and Affective Reactivity in Daily Life
Barrantes Vidal, Neus|||0000-0002-8671-1238
Schizotypy
Psychosis
Gene-environment interaction
Experience sampling methodology
Differential susceptibility
Polygenic Risk Score
title_short Genetic Differences in Reactivity to the Environment Impact Psychotic-Like and Affective Reactivity in Daily Life
title_full Genetic Differences in Reactivity to the Environment Impact Psychotic-Like and Affective Reactivity in Daily Life
title_fullStr Genetic Differences in Reactivity to the Environment Impact Psychotic-Like and Affective Reactivity in Daily Life
title_full_unstemmed Genetic Differences in Reactivity to the Environment Impact Psychotic-Like and Affective Reactivity in Daily Life
title_sort Genetic Differences in Reactivity to the Environment Impact Psychotic-Like and Affective Reactivity in Daily Life
dc.creator.none.fl_str_mv Barrantes Vidal, Neus|||0000-0002-8671-1238
Torrecilla González, Pilar|||0000-0003-2017-6014
Mas-Bermejo, Patricia|||0000-0003-4789-9650
Papiol, Sergi|||0000-0001-9366-8728
Bakermans-Kranenburg, Marian|||0000-0001-7763-0711
Rosa de la Cruz, Araceli|||0000-0001-6935-3785
Kwapil, Thomas|||0000-0003-1116-5954
author Barrantes Vidal, Neus|||0000-0002-8671-1238
author_facet Barrantes Vidal, Neus|||0000-0002-8671-1238
Torrecilla González, Pilar|||0000-0003-2017-6014
Mas-Bermejo, Patricia|||0000-0003-4789-9650
Papiol, Sergi|||0000-0001-9366-8728
Bakermans-Kranenburg, Marian|||0000-0001-7763-0711
Rosa de la Cruz, Araceli|||0000-0001-6935-3785
Kwapil, Thomas|||0000-0003-1116-5954
author_role author
author2 Torrecilla González, Pilar|||0000-0003-2017-6014
Mas-Bermejo, Patricia|||0000-0003-4789-9650
Papiol, Sergi|||0000-0001-9366-8728
Bakermans-Kranenburg, Marian|||0000-0001-7763-0711
Rosa de la Cruz, Araceli|||0000-0001-6935-3785
Kwapil, Thomas|||0000-0003-1116-5954
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Schizotypy
Psychosis
Gene-environment interaction
Experience sampling methodology
Differential susceptibility
Polygenic Risk Score
topic Schizotypy
Psychosis
Gene-environment interaction
Experience sampling methodology
Differential susceptibility
Polygenic Risk Score
description Consistent with diathesis-stress models, psychosis research has focused on genetic moderation of adverse environmental exposures. In contrast, the Differential Susceptibility (DS) model suggests that the same genetic variants that increase risk-inducing effects of adverse experiences also enhance beneficial effects from positive experiences. This study examined whether individuals with high genetic susceptibility to the environment showed differential psychotic-like and affective reactivity in response to positive and negative events in daily life. Experience sampling methodology assessed context (positive and stressful) and momentary levels of paranoia, psychotic-like experiences (PLE), and positive (PA) and negative affect (NA) in 217 non-clinical adults oversampled for schizotypy. Linear mixed models examined whether Polygenic Risk Scores of Environmental Sensitivity (PRS-ES) moderated the impact of current context on subsequent experiences. PRS-ES moderated positive, but not stressful, context on subsequent levels of momentary paranoia, NA, and PA, but not PLE. Genetic and environmental (G × E) interactions indicated diathesis-stress at lower thresholds of PRS-ES, but a DS model at the highest threshold of the PRS-ES. Participants with elevated PRS-ES showed increased paranoia and NA and decreased PA in subsequent assessments when reporting low levels of positive situations, but also decreased paranoia and NA and increased PA when rating contexts as positive. Findings support the influence of genetic sensitivity to the environment on psychotic-like and affective reactivity in daily life, particularly in response to positive contexts. This highlights the transdiagnostic protective role of positive experiences and informs ecological momentary interventions.
publishDate 2025
dc.date.none.fl_str_mv 2
2025-01-01
2025
2025-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/320999
https://dx.doi.org/urn:doi:10.1093/schbul/sbad162
url https://ddd.uab.cat/record/320999
https://dx.doi.org/urn:doi:10.1093/schbul/sbad162
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PSI2017-91814-EXP
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-119211RB-I00
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-01010
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
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