One-pot Sequential Organocatalytic Michael-Tishchenko-Lactonization Reactions. Synthesis of Enantioenriched 4, 5, 6 -Trisubstituted - Lactones

Producción Científica

Detalles Bibliográficos
Autores: Guevara Pulido, James Oswaldo, Andrés García, José María, Pedrosa Sáez, Rafael
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Universidad de Valladolid
Repositorio:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/21448
Acceso en línea:https://doi.org/10.1021/jo5013724
http://uvadoc.uva.es/handle/10324/21448
Access Level:acceso abierto
Palabra clave:Catalizadores
Química orgánica
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spelling One-pot Sequential Organocatalytic Michael-Tishchenko-Lactonization Reactions. Synthesis of Enantioenriched 4, 5, 6 -Trisubstituted - LactonesGuevara Pulido, James OswaldoAndrés García, José MaríaPedrosa Sáez, RafaelCatalizadoresQuímica orgánicaProducción CientíficaEnantioenriched trisubstituted lactones were obtained in good yields and moderate to very good enantioselectivities in one-pot process, which implies a sequential organocatalyzed Michael addition of ketones to enals, followed by catalytic intramolecular diastereoselective Tishchenko reaction and lactonization. The final lactones were obtained as single diastereoisomers, demonstrating that the mixture of the anti and syn diastereomers epimerized to the syn hydroxy ester during the oxido-reduction step.Ministerio de Economía, Industria y Competitividad (CTQ 2011-28487)Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA064U13)Universidad de Valladolid for a pre-doctoral fellowshipsAmerican Chemical Society2014info:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.1021/jo5013724http://uvadoc.uva.es/handle/10324/21448reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttp://pubs.acs.org/info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:uvadoc.uva.es:10324/214482026-06-13T12:44:47Z
dc.title.none.fl_str_mv One-pot Sequential Organocatalytic Michael-Tishchenko-Lactonization Reactions. Synthesis of Enantioenriched 4, 5, 6 -Trisubstituted - Lactones
title One-pot Sequential Organocatalytic Michael-Tishchenko-Lactonization Reactions. Synthesis of Enantioenriched 4, 5, 6 -Trisubstituted - Lactones
spellingShingle One-pot Sequential Organocatalytic Michael-Tishchenko-Lactonization Reactions. Synthesis of Enantioenriched 4, 5, 6 -Trisubstituted - Lactones
Guevara Pulido, James Oswaldo
Catalizadores
Química orgánica
title_short One-pot Sequential Organocatalytic Michael-Tishchenko-Lactonization Reactions. Synthesis of Enantioenriched 4, 5, 6 -Trisubstituted - Lactones
title_full One-pot Sequential Organocatalytic Michael-Tishchenko-Lactonization Reactions. Synthesis of Enantioenriched 4, 5, 6 -Trisubstituted - Lactones
title_fullStr One-pot Sequential Organocatalytic Michael-Tishchenko-Lactonization Reactions. Synthesis of Enantioenriched 4, 5, 6 -Trisubstituted - Lactones
title_full_unstemmed One-pot Sequential Organocatalytic Michael-Tishchenko-Lactonization Reactions. Synthesis of Enantioenriched 4, 5, 6 -Trisubstituted - Lactones
title_sort One-pot Sequential Organocatalytic Michael-Tishchenko-Lactonization Reactions. Synthesis of Enantioenriched 4, 5, 6 -Trisubstituted - Lactones
dc.creator.none.fl_str_mv Guevara Pulido, James Oswaldo
Andrés García, José María
Pedrosa Sáez, Rafael
author Guevara Pulido, James Oswaldo
author_facet Guevara Pulido, James Oswaldo
Andrés García, José María
Pedrosa Sáez, Rafael
author_role author
author2 Andrés García, José María
Pedrosa Sáez, Rafael
author2_role author
author
dc.subject.none.fl_str_mv Catalizadores
Química orgánica
topic Catalizadores
Química orgánica
description Producción Científica
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://doi.org/10.1021/jo5013724
http://uvadoc.uva.es/handle/10324/21448
url https://doi.org/10.1021/jo5013724
http://uvadoc.uva.es/handle/10324/21448
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://pubs.acs.org/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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