Cognitive behavioral therapy program for cannabis use cessation in first-episode psychosis patients: study protocol for a randomized controlled trial

Background: The high rate of cannabis use among patients with first-episode psychosis (FEP), as well as the associated negative impact on illness course and treatment outcomes, underlines the need for effective interventions in these populations. However, to date, there have been few clinical treatm...

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Autores: González Ortega, Itxaso, Echeburúa Odriozola, Enrique, García-Alocén, Adriana, Vega, Patricia, González Pinto Arrillaga, Ana María
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/32407
Acceso en línea:http://hdl.handle.net/10810/32407
Access Level:acceso abierto
Palabra clave:cannabis
first-episode psychosis
psychological treatment
age-of-onset
1st episode psychosis
clinical high-risk
medication adherence
predictive-validity
anandamide levels
use disorders
substance use
young-people
schizophrenia
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spelling Cognitive behavioral therapy program for cannabis use cessation in first-episode psychosis patients: study protocol for a randomized controlled trialGonzález Ortega, ItxasoEcheburúa Odriozola, EnriqueGarcía-Alocén, AdrianaVega, PatriciaGonzález Pinto Arrillaga, Ana Maríacannabisfirst-episode psychosispsychological treatmentage-of-onset1st episode psychosisclinical high-riskmedication adherencepredictive-validityanandamide levelsuse disorderssubstance useyoung-peopleschizophreniaBackground: The high rate of cannabis use among patients with first-episode psychosis (FEP), as well as the associated negative impact on illness course and treatment outcomes, underlines the need for effective interventions in these populations. However, to date, there have been few clinical treatment trials (of pharmacological or psychological interventions) that have specifically focused on addressing comorbid cannabis use among these patients. The aim of this paper is to describe the design of a study protocol for a randomized controlled trial in which the objective is to assess the efficacy of a specific cognitive behavioral therapy program for cannabis cessation in patients with FEP compared to standard treatment (psychoeducation). Methods/design: This is a single-blind randomized study with 1 year of follow-up. Patients are to be randomly assigned to one of two treatments: (1) specific cognitive behavioral therapy for cannabis cessation composed of 1-hour sessions once a week for 16 weeks, in addition to pharmacological treatment scheduled by the psychiatrist, or (2) a control group (psychoeducation + pharmacological treatment) following the same format as the experimental group. Participants in both groups will be evaluated at baseline (pre-treatment), at 16 weeks (post-treatment), and at 3 and 6 months and 1 year of follow-up. The primary outcome will be that patients in the experimental group will have greater cannabis cessation than patients in the control group at post-treatment. The secondary outcome will be that the experimental group will have better clinical and functional outcomes than the control group. Discussion: This study provides the description of a clinical trial design based on specific cognitive behavioral therapy for cannabis cessation in FEP patients, aiming to improve clinical and functional outcome, as well as tackling the addictive disorder.This study is funded by the Spanish Ministry of Economy and Competitiveness, through the Carlos III Health Institute (ISCIII), and the European Regional Development Fund (ERDF) (PI13/02252).Biomed Central201920192016info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/32407reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/grantAgreement/MINECO/PI13/02252https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-016-1507-xinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Atribución 3.0 Españaoai:addi.ehu.eus:10810/324072026-06-18T09:23:17Z
dc.title.none.fl_str_mv Cognitive behavioral therapy program for cannabis use cessation in first-episode psychosis patients: study protocol for a randomized controlled trial
title Cognitive behavioral therapy program for cannabis use cessation in first-episode psychosis patients: study protocol for a randomized controlled trial
spellingShingle Cognitive behavioral therapy program for cannabis use cessation in first-episode psychosis patients: study protocol for a randomized controlled trial
González Ortega, Itxaso
cannabis
first-episode psychosis
psychological treatment
age-of-onset
1st episode psychosis
clinical high-risk
medication adherence
predictive-validity
anandamide levels
use disorders
substance use
young-people
schizophrenia
title_short Cognitive behavioral therapy program for cannabis use cessation in first-episode psychosis patients: study protocol for a randomized controlled trial
title_full Cognitive behavioral therapy program for cannabis use cessation in first-episode psychosis patients: study protocol for a randomized controlled trial
title_fullStr Cognitive behavioral therapy program for cannabis use cessation in first-episode psychosis patients: study protocol for a randomized controlled trial
title_full_unstemmed Cognitive behavioral therapy program for cannabis use cessation in first-episode psychosis patients: study protocol for a randomized controlled trial
title_sort Cognitive behavioral therapy program for cannabis use cessation in first-episode psychosis patients: study protocol for a randomized controlled trial
dc.creator.none.fl_str_mv González Ortega, Itxaso
Echeburúa Odriozola, Enrique
García-Alocén, Adriana
Vega, Patricia
González Pinto Arrillaga, Ana María
author González Ortega, Itxaso
author_facet González Ortega, Itxaso
Echeburúa Odriozola, Enrique
García-Alocén, Adriana
Vega, Patricia
González Pinto Arrillaga, Ana María
author_role author
author2 Echeburúa Odriozola, Enrique
García-Alocén, Adriana
Vega, Patricia
González Pinto Arrillaga, Ana María
author2_role author
author
author
author
dc.subject.none.fl_str_mv cannabis
first-episode psychosis
psychological treatment
age-of-onset
1st episode psychosis
clinical high-risk
medication adherence
predictive-validity
anandamide levels
use disorders
substance use
young-people
schizophrenia
topic cannabis
first-episode psychosis
psychological treatment
age-of-onset
1st episode psychosis
clinical high-risk
medication adherence
predictive-validity
anandamide levels
use disorders
substance use
young-people
schizophrenia
description Background: The high rate of cannabis use among patients with first-episode psychosis (FEP), as well as the associated negative impact on illness course and treatment outcomes, underlines the need for effective interventions in these populations. However, to date, there have been few clinical treatment trials (of pharmacological or psychological interventions) that have specifically focused on addressing comorbid cannabis use among these patients. The aim of this paper is to describe the design of a study protocol for a randomized controlled trial in which the objective is to assess the efficacy of a specific cognitive behavioral therapy program for cannabis cessation in patients with FEP compared to standard treatment (psychoeducation). Methods/design: This is a single-blind randomized study with 1 year of follow-up. Patients are to be randomly assigned to one of two treatments: (1) specific cognitive behavioral therapy for cannabis cessation composed of 1-hour sessions once a week for 16 weeks, in addition to pharmacological treatment scheduled by the psychiatrist, or (2) a control group (psychoeducation + pharmacological treatment) following the same format as the experimental group. Participants in both groups will be evaluated at baseline (pre-treatment), at 16 weeks (post-treatment), and at 3 and 6 months and 1 year of follow-up. The primary outcome will be that patients in the experimental group will have greater cannabis cessation than patients in the control group at post-treatment. The secondary outcome will be that the experimental group will have better clinical and functional outcomes than the control group. Discussion: This study provides the description of a clinical trial design based on specific cognitive behavioral therapy for cannabis cessation in FEP patients, aiming to improve clinical and functional outcome, as well as tackling the addictive disorder.
publishDate 2016
dc.date.none.fl_str_mv 2016
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/32407
url http://hdl.handle.net/10810/32407
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MINECO/PI13/02252
https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-016-1507-x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Biomed Central
publisher.none.fl_str_mv Biomed Central
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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