Cost-effectiveness analysis of the daily HIV pre-exposure prophylaxis in men who have sex with men in Barcelona

Introduction. Pre-Exposure Prophylaxis (PrEP) for HIV prevention has been implemented in several countries. Previous literature has shown that its cost-effectiveness (and, under some specifications, cost-saving character) is dependent on the reduction in price due to generics, the time-horizon and i...

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Authors: López Seguí, Francesc, 1991-, Oyón Lerga, Unai, Laguna Marmol, Laura, Coll, Pep, Andreu, Angels, Meulbroek, Michael, López i Casasnovas, Guillem, Estrada Cuxart, Oriol, Ara del Rey, Jordi, Quiñones, Carles; Pérez, Fèlix, Fernandez, Javier, Rivero, Àngel, Ricou Ríos, Laura, Clotet, Bonaventura
Format: article
Status:Published version
Publication Date:2023
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/58379
Online Access:http://hdl.handle.net/10230/58379
http://dx.doi.org/10.1371/journal.pone.0277571
Access Level:Open access
Keyword:Serologia
VIH (Virus)
Infeccions per VIH
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spelling Cost-effectiveness analysis of the daily HIV pre-exposure prophylaxis in men who have sex with men in BarcelonaLópez Seguí, Francesc, 1991-Oyón Lerga, UnaiLaguna Marmol, LauraColl, PepAndreu, AngelsMeulbroek, MichaelLópez i Casasnovas, GuillemEstrada Cuxart, OriolAra del Rey, JordiQuiñones, Carles; Pérez, FèlixFernandez, JavierRivero, ÀngelRicou Ríos, LauraClotet, BonaventuraSerologiaVIH (Virus)Infeccions per VIHIntroduction. Pre-Exposure Prophylaxis (PrEP) for HIV prevention has been implemented in several countries. Previous literature has shown that its cost-effectiveness (and, under some specifications, cost-saving character) is dependent on the reduction in price due to generics, the time-horizon and its effectiveness. The intervention has never been studied in Catalonia after the approval of the PrEP, a territory with extensive implementation. Methods. Economic evaluation of the implementation of HIV pre-exposition prophylaxis using administrative data from Men who have Sex with Men (MSM) who receive the treatment (at the generic price) compared with non-implementation. A deterministic compartmental model and a social perspective with a micro-costing approach over the time horizon 2022–2062 are used. A baseline 86% effectiveness of PrEP is assumed. Results. Daily oral PrEP is found to be cost-saving: discounted savings in costs are attained after 16 years, and after 40 years they reach 81 million euros. In terms of health indicators, 10,322 additional discounted QALYs are generated by the intervention. Results are sensitive to sexual behavioral patterns among MSM, the price of PrEP (reduced if offered on-demand), its effectiveness and the discount rate. Conclusions. The use and promotion of PrEP in Catalonia is predicted to result in substantial health and monetary benefits because of reductions in HIV infections. Short-term investments in the promotion of PrEP will result in important cost-savings in the long term.Public Library of Science (PLoS)202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/58379http://dx.doi.org/10.1371/journal.pone.0277571reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésPLoS ONE. 2023 Jan 17;18(1):e0277571© 2023 López Seguí et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/583792026-05-29T05:05:01Z
dc.title.none.fl_str_mv Cost-effectiveness analysis of the daily HIV pre-exposure prophylaxis in men who have sex with men in Barcelona
title Cost-effectiveness analysis of the daily HIV pre-exposure prophylaxis in men who have sex with men in Barcelona
spellingShingle Cost-effectiveness analysis of the daily HIV pre-exposure prophylaxis in men who have sex with men in Barcelona
López Seguí, Francesc, 1991-
Serologia
VIH (Virus)
Infeccions per VIH
title_short Cost-effectiveness analysis of the daily HIV pre-exposure prophylaxis in men who have sex with men in Barcelona
title_full Cost-effectiveness analysis of the daily HIV pre-exposure prophylaxis in men who have sex with men in Barcelona
title_fullStr Cost-effectiveness analysis of the daily HIV pre-exposure prophylaxis in men who have sex with men in Barcelona
title_full_unstemmed Cost-effectiveness analysis of the daily HIV pre-exposure prophylaxis in men who have sex with men in Barcelona
title_sort Cost-effectiveness analysis of the daily HIV pre-exposure prophylaxis in men who have sex with men in Barcelona
dc.creator.none.fl_str_mv López Seguí, Francesc, 1991-
Oyón Lerga, Unai
Laguna Marmol, Laura
Coll, Pep
Andreu, Angels
Meulbroek, Michael
López i Casasnovas, Guillem
Estrada Cuxart, Oriol
Ara del Rey, Jordi
Quiñones, Carles; Pérez, Fèlix
Fernandez, Javier
Rivero, Àngel
Ricou Ríos, Laura
Clotet, Bonaventura
author López Seguí, Francesc, 1991-
author_facet López Seguí, Francesc, 1991-
Oyón Lerga, Unai
Laguna Marmol, Laura
Coll, Pep
Andreu, Angels
Meulbroek, Michael
López i Casasnovas, Guillem
Estrada Cuxart, Oriol
Ara del Rey, Jordi
Quiñones, Carles; Pérez, Fèlix
Fernandez, Javier
Rivero, Àngel
Ricou Ríos, Laura
Clotet, Bonaventura
author_role author
author2 Oyón Lerga, Unai
Laguna Marmol, Laura
Coll, Pep
Andreu, Angels
Meulbroek, Michael
López i Casasnovas, Guillem
Estrada Cuxart, Oriol
Ara del Rey, Jordi
Quiñones, Carles; Pérez, Fèlix
Fernandez, Javier
Rivero, Àngel
Ricou Ríos, Laura
Clotet, Bonaventura
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Serologia
VIH (Virus)
Infeccions per VIH
topic Serologia
VIH (Virus)
Infeccions per VIH
description Introduction. Pre-Exposure Prophylaxis (PrEP) for HIV prevention has been implemented in several countries. Previous literature has shown that its cost-effectiveness (and, under some specifications, cost-saving character) is dependent on the reduction in price due to generics, the time-horizon and its effectiveness. The intervention has never been studied in Catalonia after the approval of the PrEP, a territory with extensive implementation. Methods. Economic evaluation of the implementation of HIV pre-exposition prophylaxis using administrative data from Men who have Sex with Men (MSM) who receive the treatment (at the generic price) compared with non-implementation. A deterministic compartmental model and a social perspective with a micro-costing approach over the time horizon 2022–2062 are used. A baseline 86% effectiveness of PrEP is assumed. Results. Daily oral PrEP is found to be cost-saving: discounted savings in costs are attained after 16 years, and after 40 years they reach 81 million euros. In terms of health indicators, 10,322 additional discounted QALYs are generated by the intervention. Results are sensitive to sexual behavioral patterns among MSM, the price of PrEP (reduced if offered on-demand), its effectiveness and the discount rate. Conclusions. The use and promotion of PrEP in Catalonia is predicted to result in substantial health and monetary benefits because of reductions in HIV infections. Short-term investments in the promotion of PrEP will result in important cost-savings in the long term.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/58379
http://dx.doi.org/10.1371/journal.pone.0277571
url http://hdl.handle.net/10230/58379
http://dx.doi.org/10.1371/journal.pone.0277571
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv PLoS ONE. 2023 Jan 17;18(1):e0277571
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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