Topography of activation deficits in schizophrenia during P300 task related to cognition and structural connectivity

Background The study of cerebral underpinnings of schizophrenia may benefit from the high temporal resolution of electromagnetic techniques, but its spatial resolution is low. However, source imaging approaches such as low-resolution brain electromagnetic tomography (LORETA) allow for an acceptable...

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Autores: Molina Rodriguez, Vicente, Bachiller Matarranz, Alejandro|||0000-0001-6507-1027, Luis García, Rodrigo de, Lubeiro Juárez, Alba, Poza Crespo, Jesús, Hornero Sánchez, Roberto, Alonso López, Joan Francesc|||0000-0002-2980-6716, Mañanas Villanueva, Miguel Ángel|||0000-0001-9836-6083, Marques, Patricia, Romero Lafuente, Sergio|||0000-0002-8627-543X
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/130884
Acceso en línea:https://hdl.handle.net/2117/130884
https://dx.doi.org/10.1007/s00406-018-0877-3
Access Level:acceso abierto
Palabra clave:Magnetic resonance imaging
Tomography
Schizophrenia--Diagnosis
Schizophrenia
LORETA
EEG
Diffusion tensor
Anterior cingulate
Imatgeria per ressonància magnètica
Tomografia
Esquizofrènia
Esquizofrènia -- Diagnòstic
Àrees temàtiques de la UPC::Ciències de la salut::Medicina
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spelling Topography of activation deficits in schizophrenia during P300 task related to cognition and structural connectivityMolina Rodriguez, VicenteBachiller Matarranz, Alejandro|||0000-0001-6507-1027Luis García, Rodrigo deLubeiro Juárez, AlbaPoza Crespo, JesúsHornero Sánchez, RobertoAlonso López, Joan Francesc|||0000-0002-2980-6716Mañanas Villanueva, Miguel Ángel|||0000-0001-9836-6083Marques, PatriciaRomero Lafuente, Sergio|||0000-0002-8627-543XMagnetic resonance imagingTomographySchizophrenia--DiagnosisSchizophreniaLORETAEEGDiffusion tensorAnterior cingulateImatgeria per ressonància magnèticaTomografiaEsquizofrèniaEsquizofrènia -- DiagnòsticÀrees temàtiques de la UPC::Ciències de la salut::MedicinaBackground The study of cerebral underpinnings of schizophrenia may benefit from the high temporal resolution of electromagnetic techniques, but its spatial resolution is low. However, source imaging approaches such as low-resolution brain electromagnetic tomography (LORETA) allow for an acceptable compromise between spatial and temporal resolutions. Methods We combined LORETA with 32 channels and 3-Tesla diffusion magnetic resonance (Dmr) to study cerebral dysfunction in 38 schizophrenia patients (17 first episodes, FE), compared to 53 healthy controls. The EEG was acquired with subjects performing an odd-ball task. Analyses included an adaptive window of interest to take into account the interindividual variability of P300 latency. We compared source activation patters to distractor (P3a) and target (P3b) tones within- and between-groups. Results Patients showed a reduced activation in anterior cingulate and lateral and medial prefrontal cortices, as well as inferior/orbital frontal regions. This was also found in the FE patients alone. The activation was directly related to IQ in the patients and controls and to working memory performance in controls. Symptoms were unrelated to source activation. Fractional anisotropy in the tracts connecting lateral prefrontal and anterior cingulate regions predicted source activation in these regions in the patients. Conclusions These results replicate the source activation deficit found in a previous study with smaller sample size and a lower number of sensors and suggest an association between structural connectivity deficits and functional alterations.20182018-02-0220192019-03-26journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/130884https://dx.doi.org/10.1007/s00406-018-0877-3reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/1308842026-05-27T15:37:01Z
dc.title.none.fl_str_mv Topography of activation deficits in schizophrenia during P300 task related to cognition and structural connectivity
title Topography of activation deficits in schizophrenia during P300 task related to cognition and structural connectivity
spellingShingle Topography of activation deficits in schizophrenia during P300 task related to cognition and structural connectivity
Molina Rodriguez, Vicente
Magnetic resonance imaging
Tomography
Schizophrenia--Diagnosis
Schizophrenia
LORETA
EEG
Diffusion tensor
Anterior cingulate
Imatgeria per ressonància magnètica
Tomografia
Esquizofrènia
Esquizofrènia -- Diagnòstic
Àrees temàtiques de la UPC::Ciències de la salut::Medicina
title_short Topography of activation deficits in schizophrenia during P300 task related to cognition and structural connectivity
title_full Topography of activation deficits in schizophrenia during P300 task related to cognition and structural connectivity
title_fullStr Topography of activation deficits in schizophrenia during P300 task related to cognition and structural connectivity
title_full_unstemmed Topography of activation deficits in schizophrenia during P300 task related to cognition and structural connectivity
title_sort Topography of activation deficits in schizophrenia during P300 task related to cognition and structural connectivity
dc.creator.none.fl_str_mv Molina Rodriguez, Vicente
Bachiller Matarranz, Alejandro|||0000-0001-6507-1027
Luis García, Rodrigo de
Lubeiro Juárez, Alba
Poza Crespo, Jesús
Hornero Sánchez, Roberto
Alonso López, Joan Francesc|||0000-0002-2980-6716
Mañanas Villanueva, Miguel Ángel|||0000-0001-9836-6083
Marques, Patricia
Romero Lafuente, Sergio|||0000-0002-8627-543X
author Molina Rodriguez, Vicente
author_facet Molina Rodriguez, Vicente
Bachiller Matarranz, Alejandro|||0000-0001-6507-1027
Luis García, Rodrigo de
Lubeiro Juárez, Alba
Poza Crespo, Jesús
Hornero Sánchez, Roberto
Alonso López, Joan Francesc|||0000-0002-2980-6716
Mañanas Villanueva, Miguel Ángel|||0000-0001-9836-6083
Marques, Patricia
Romero Lafuente, Sergio|||0000-0002-8627-543X
author_role author
author2 Bachiller Matarranz, Alejandro|||0000-0001-6507-1027
Luis García, Rodrigo de
Lubeiro Juárez, Alba
Poza Crespo, Jesús
Hornero Sánchez, Roberto
Alonso López, Joan Francesc|||0000-0002-2980-6716
Mañanas Villanueva, Miguel Ángel|||0000-0001-9836-6083
Marques, Patricia
Romero Lafuente, Sergio|||0000-0002-8627-543X
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Magnetic resonance imaging
Tomography
Schizophrenia--Diagnosis
Schizophrenia
LORETA
EEG
Diffusion tensor
Anterior cingulate
Imatgeria per ressonància magnètica
Tomografia
Esquizofrènia
Esquizofrènia -- Diagnòstic
Àrees temàtiques de la UPC::Ciències de la salut::Medicina
topic Magnetic resonance imaging
Tomography
Schizophrenia--Diagnosis
Schizophrenia
LORETA
EEG
Diffusion tensor
Anterior cingulate
Imatgeria per ressonància magnètica
Tomografia
Esquizofrènia
Esquizofrènia -- Diagnòstic
Àrees temàtiques de la UPC::Ciències de la salut::Medicina
description Background The study of cerebral underpinnings of schizophrenia may benefit from the high temporal resolution of electromagnetic techniques, but its spatial resolution is low. However, source imaging approaches such as low-resolution brain electromagnetic tomography (LORETA) allow for an acceptable compromise between spatial and temporal resolutions. Methods We combined LORETA with 32 channels and 3-Tesla diffusion magnetic resonance (Dmr) to study cerebral dysfunction in 38 schizophrenia patients (17 first episodes, FE), compared to 53 healthy controls. The EEG was acquired with subjects performing an odd-ball task. Analyses included an adaptive window of interest to take into account the interindividual variability of P300 latency. We compared source activation patters to distractor (P3a) and target (P3b) tones within- and between-groups. Results Patients showed a reduced activation in anterior cingulate and lateral and medial prefrontal cortices, as well as inferior/orbital frontal regions. This was also found in the FE patients alone. The activation was directly related to IQ in the patients and controls and to working memory performance in controls. Symptoms were unrelated to source activation. Fractional anisotropy in the tracts connecting lateral prefrontal and anterior cingulate regions predicted source activation in these regions in the patients. Conclusions These results replicate the source activation deficit found in a previous study with smaller sample size and a lower number of sensors and suggest an association between structural connectivity deficits and functional alterations.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-02-02
2019
2019-03-26
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/130884
https://dx.doi.org/10.1007/s00406-018-0877-3
url https://hdl.handle.net/2117/130884
https://dx.doi.org/10.1007/s00406-018-0877-3
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
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repository.mail.fl_str_mv
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