Neuraminidase antibodies and H5N1: geographic-dependent influenza epidemiology could determine cross-protection against emerging strains

We have read with great interest the work of Sandbulte et al. recently published in your journal [1]. In this article, the authors provide evidence for the existence of cross-immunity between the neuraminidase of H5N1 viruses and that of endemic human H1N1 viruses. Age may be an important determinin...

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Detalles Bibliográficos
Autores: Bermejo-Martin, Jesús F, Kelvin, David J, Guan, Yi, Chen, Honglin, Perez-Breña, Pilar, Casas Flecha, Inmaculada, Arranz, Eduardo, Ortíz de Lejarazu, Raúl
Tipo de recurso: artículo
Fecha de publicación:2007
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/11614
Acceso en línea:http://hdl.handle.net/20.500.12105/11614
Access Level:acceso abierto
Palabra clave:Animals
Antibodies, Viral
Disease Outbreaks
Humans
Influenza A Virus, H5N1 Subtype
Influenza Vaccines
Influenza, Human
Mice
Neuraminidase
Orthomyxoviridae Infections
Descripción
Sumario:We have read with great interest the work of Sandbulte et al. recently published in your journal [1]. In this article, the authors provide evidence for the existence of cross-immunity between the neuraminidase of H5N1 viruses and that of endemic human H1N1 viruses. Age may be an important determining factor in the development of cross-immunity: younger people, having a shorter history of H1N1 exposure, may be disproportionately susceptible to H5N1 infection.