In Vitro anticancer properties of copper metallodendrimers

Newly synthesized carbosilane copper dendrimers (CCD) with chloride and nitrate surface groups seem to be good candidates to be used as gene and drug carriers in anti-cancer therapy, due to their properties such as size and surface charge. Copper attached to the nanoparticles is an important element...

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Autores: Holota, Marcin, Magiera, Jakub, Michlewska, Sylwia, Kubczak, Malgorzata, Sanz del Olmo, Natalia, García Gallego, Sandra|||0000-0001-6112-0450, Ortega Lopez, Paula|||0000-0003-0377-5429, Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935, Ionov, Maksim, Bryszewska, Maria
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad de Alcalá (UAH)
Repositorio:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglés
OAI Identifier:oai:ebuah.uah.es:10017/37505
Acceso en línea:http://hdl.handle.net/10017/37505
https://dx.doi.org/10.3390/biom9040155
Access Level:acceso abierto
Palabra clave:copper metallodendrimers
anticancer therapeutic agent
nanocarrier
structure
cytotoxicity
Química
Chemistry
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spelling In Vitro anticancer properties of copper metallodendrimersHolota, MarcinMagiera, JakubMichlewska, SylwiaKubczak, MalgorzataSanz del Olmo, NataliaGarcía Gallego, Sandra|||0000-0001-6112-0450Ortega Lopez, Paula|||0000-0003-0377-5429Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935Ionov, MaksimBryszewska, Mariacopper metallodendrimersanticancer therapeutic agentnanocarrierstructurecytotoxicityQuímicaChemistryNewly synthesized carbosilane copper dendrimers (CCD) with chloride and nitrate surface groups seem to be good candidates to be used as gene and drug carriers in anti-cancer therapy, due to their properties such as size and surface charge. Copper attached to the nanoparticles is an important element of many biological processes and recently their anti-cancer properties have been widely examined. Zeta size and potential, transmission electron microscopy (TEM), circular dichroism (CD), analysis of haemolytic activity, and fluorescence anisotropy techniques were used to characterize copper dendrimers. Additionally, their cytotoxic properties toward normal (PBMC) and cancer (1301; HL-60) cells were examined. All tested dendrimers were more cytotoxic against cancer cells in comparison with normal cells.Comunidad de MadridAgencia Española de InvestigaciónJunta de Comunidades de Castilla-la Mancha20192019-04-18journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/37505https://dx.doi.org/10.3390/biom9040155reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)InglésengJunta de Comunidades de Castilla-La Mancha http://dx.doi.org/10.13039/501100011698 Not available SBPLY%2F17%2F180501%2F000358 NANOSISTEMAS DENDRÍTICOS POLIFENÓLICOS: APLICACIONES EN COSMÉTICA Y BIOMEDICINAAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 CTQ2017-86224-P DENDRONIZACION COMO HERRAMIENTA SINTÉTICA DE OBTENCIÓN DE NANOSISTEMAS DENDRÍTICOS ESPECIFICAMENTE DISEÑADOS PARA SU USO EN APLICACIONES BIOMÉDICASComunidad de Madrid http://dx.doi.org/10.13039/100012818 Programas de Actividades de I+D entre Grupos de Investigación de la Comunidad de Madrid en Biomedicina B2017%2FBMD-3733 INMUNIDAD TUMORAL E INMUNOTERAPIA DEL CANCERopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/375052026-06-18T11:13:07Z
dc.title.none.fl_str_mv In Vitro anticancer properties of copper metallodendrimers
title In Vitro anticancer properties of copper metallodendrimers
spellingShingle In Vitro anticancer properties of copper metallodendrimers
Holota, Marcin
copper metallodendrimers
anticancer therapeutic agent
nanocarrier
structure
cytotoxicity
Química
Chemistry
title_short In Vitro anticancer properties of copper metallodendrimers
title_full In Vitro anticancer properties of copper metallodendrimers
title_fullStr In Vitro anticancer properties of copper metallodendrimers
title_full_unstemmed In Vitro anticancer properties of copper metallodendrimers
title_sort In Vitro anticancer properties of copper metallodendrimers
dc.creator.none.fl_str_mv Holota, Marcin
Magiera, Jakub
Michlewska, Sylwia
Kubczak, Malgorzata
Sanz del Olmo, Natalia
García Gallego, Sandra|||0000-0001-6112-0450
Ortega Lopez, Paula|||0000-0003-0377-5429
Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935
Ionov, Maksim
Bryszewska, Maria
author Holota, Marcin
author_facet Holota, Marcin
Magiera, Jakub
Michlewska, Sylwia
Kubczak, Malgorzata
Sanz del Olmo, Natalia
García Gallego, Sandra|||0000-0001-6112-0450
Ortega Lopez, Paula|||0000-0003-0377-5429
Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935
Ionov, Maksim
Bryszewska, Maria
author_role author
author2 Magiera, Jakub
Michlewska, Sylwia
Kubczak, Malgorzata
Sanz del Olmo, Natalia
García Gallego, Sandra|||0000-0001-6112-0450
Ortega Lopez, Paula|||0000-0003-0377-5429
Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935
Ionov, Maksim
Bryszewska, Maria
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv copper metallodendrimers
anticancer therapeutic agent
nanocarrier
structure
cytotoxicity
Química
Chemistry
topic copper metallodendrimers
anticancer therapeutic agent
nanocarrier
structure
cytotoxicity
Química
Chemistry
description Newly synthesized carbosilane copper dendrimers (CCD) with chloride and nitrate surface groups seem to be good candidates to be used as gene and drug carriers in anti-cancer therapy, due to their properties such as size and surface charge. Copper attached to the nanoparticles is an important element of many biological processes and recently their anti-cancer properties have been widely examined. Zeta size and potential, transmission electron microscopy (TEM), circular dichroism (CD), analysis of haemolytic activity, and fluorescence anisotropy techniques were used to characterize copper dendrimers. Additionally, their cytotoxic properties toward normal (PBMC) and cancer (1301; HL-60) cells were examined. All tested dendrimers were more cytotoxic against cancer cells in comparison with normal cells.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-04-18
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/37505
https://dx.doi.org/10.3390/biom9040155
url http://hdl.handle.net/10017/37505
https://dx.doi.org/10.3390/biom9040155
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Junta de Comunidades de Castilla-La Mancha http://dx.doi.org/10.13039/501100011698 Not available SBPLY%2F17%2F180501%2F000358 NANOSISTEMAS DENDRÍTICOS POLIFENÓLICOS: APLICACIONES EN COSMÉTICA Y BIOMEDICINA
Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 CTQ2017-86224-P DENDRONIZACION COMO HERRAMIENTA SINTÉTICA DE OBTENCIÓN DE NANOSISTEMAS DENDRÍTICOS ESPECIFICAMENTE DISEÑADOS PARA SU USO EN APLICACIONES BIOMÉDICAS
Comunidad de Madrid http://dx.doi.org/10.13039/100012818 Programas de Actividades de I+D entre Grupos de Investigación de la Comunidad de Madrid en Biomedicina B2017%2FBMD-3733 INMUNIDAD TUMORAL E INMUNOTERAPIA DEL CANCER
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
repository.name.fl_str_mv
repository.mail.fl_str_mv
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