Spanish Pediatric Inflammatory Bowel Disease Diagnostic Delay Registry: SPIDER Study From Sociedad Espanola de Gastroenterologia, Hepatologia y Nutricion Pediatrica

Background and Aims: Diagnostic delay (DD) is especially relevant in children with inflammatory bowel disease, leading to potential complications. We examined the intervals and factors for DD in the pediatric population of Spain. Methods: We conducted a multicentric prospective study, including 149...

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Autores: Trevino, SJ, Muncunill, GP, Martin-Masot, R, Martinez, AR, Canton, OS, Quintana, LP, Ramos, HA, Arocena, FJE, Torres, JB, Burriel, JIG, Castillo, LO, Aliaga, ED, Martinez, VC, Garcia, PB, Arcos, GB, Porro, JMB, Ruiz, MJ, Sangrador, CO, Casales, ZG, Poblet, GG, Goicolea, PO, Garrido, HL, Romero, RG, Izquierdo, EL, Solis, DP, Navas-Lopez, VM, Martin, JJD, de Carpi, JM
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p8566
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/8566
Access Level:acceso abierto
Palabra clave:inflammatory bowel disease
Crohn&apos
s disease
ulcerative colitis
diagnostic delay
time to diagnosis
children
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spelling Spanish Pediatric Inflammatory Bowel Disease Diagnostic Delay Registry: SPIDER Study From Sociedad Espanola de Gastroenterologia, Hepatologia y Nutricion PediatricaTrevino, SJMuncunill, GPMartin-Masot, RMartinez, ARCanton, OSQuintana, LPRamos, HAArocena, FJETorres, JBBurriel, JIGCastillo, LOAliaga, EDMartinez, VCGarcia, PBArcos, GBPorro, JMBRuiz, MJSangrador, COCasales, ZGPoblet, GGGoicolea, POGarrido, HLRomero, RGIzquierdo, ELSolis, DPNavas-Lopez, VMMartin, JJDde Carpi, JMinflammatory bowel diseaseCrohn&aposs diseaseulcerative colitisdiagnostic delaytime to diagnosischildrenBackground and Aims: Diagnostic delay (DD) is especially relevant in children with inflammatory bowel disease, leading to potential complications. We examined the intervals and factors for DD in the pediatric population of Spain. Methods: We conducted a multicentric prospective study, including 149 pediatric inflammatory bowel disease patients, obtaining clinical, anthropometric, and biochemical data. Time to diagnosis (TD) was divided into several intervals to identify those where the DD was longer and find the variables that prolonged those intervals. Missed opportunities for diagnosis (MODs) were also identified. Results: Overall TD was 4.4 months (interquartile range [IQR] 2.6-10.4), being significantly higher in Crohn's disease (CD) than in ulcerative colitis (UC) (6.3 [IQR 3.3-12.3] vs. 3 [IQR 1.6-5.6] months, p = 0.0001). Time from the visit to the first physician until referral to a pediatric gastroenterologist was the main contributor to TD (2.4 months [IQR 1.03-7.17] in CD vs. 0.83 months [IQR 0.30-2.50] in UC, p = 0.0001). One hundred and ten patients (78.3%) visited more than one physician (29.9% to 4 or more), and 16.3% visited the same physician more than six times before being assessed by the pediatric gastroenterologist. The number of MODs was significantly higher in CD than that in UC patients: 4 MODs (IQR 2-7) vs. 2 MODs ([IQR 1-5], p = 0.003). Referral by pediatricians from hospital care allowed earlier IBD diagnosis (odds ratio 3.2 [95% confidence interval 1.1-8.9], p = 0.025). Conclusions: TD and DD were significantly higher in CD than those in UC. IBD patients (especially those with CD) undergo a large number of medical visits until the final diagnosis.FRONTIERS MEDIA SA2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/8566Frontiers in PediatricsISSN: 22962360reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p85662026-06-11T12:45:17Z
dc.title.none.fl_str_mv Spanish Pediatric Inflammatory Bowel Disease Diagnostic Delay Registry: SPIDER Study From Sociedad Espanola de Gastroenterologia, Hepatologia y Nutricion Pediatrica
title Spanish Pediatric Inflammatory Bowel Disease Diagnostic Delay Registry: SPIDER Study From Sociedad Espanola de Gastroenterologia, Hepatologia y Nutricion Pediatrica
spellingShingle Spanish Pediatric Inflammatory Bowel Disease Diagnostic Delay Registry: SPIDER Study From Sociedad Espanola de Gastroenterologia, Hepatologia y Nutricion Pediatrica
Trevino, SJ
inflammatory bowel disease
Crohn&apos
s disease
ulcerative colitis
diagnostic delay
time to diagnosis
children
title_short Spanish Pediatric Inflammatory Bowel Disease Diagnostic Delay Registry: SPIDER Study From Sociedad Espanola de Gastroenterologia, Hepatologia y Nutricion Pediatrica
title_full Spanish Pediatric Inflammatory Bowel Disease Diagnostic Delay Registry: SPIDER Study From Sociedad Espanola de Gastroenterologia, Hepatologia y Nutricion Pediatrica
title_fullStr Spanish Pediatric Inflammatory Bowel Disease Diagnostic Delay Registry: SPIDER Study From Sociedad Espanola de Gastroenterologia, Hepatologia y Nutricion Pediatrica
title_full_unstemmed Spanish Pediatric Inflammatory Bowel Disease Diagnostic Delay Registry: SPIDER Study From Sociedad Espanola de Gastroenterologia, Hepatologia y Nutricion Pediatrica
title_sort Spanish Pediatric Inflammatory Bowel Disease Diagnostic Delay Registry: SPIDER Study From Sociedad Espanola de Gastroenterologia, Hepatologia y Nutricion Pediatrica
dc.creator.none.fl_str_mv Trevino, SJ
Muncunill, GP
Martin-Masot, R
Martinez, AR
Canton, OS
Quintana, LP
Ramos, HA
Arocena, FJE
Torres, JB
Burriel, JIG
Castillo, LO
Aliaga, ED
Martinez, VC
Garcia, PB
Arcos, GB
Porro, JMB
Ruiz, MJ
Sangrador, CO
Casales, ZG
Poblet, GG
Goicolea, PO
Garrido, HL
Romero, RG
Izquierdo, EL
Solis, DP
Navas-Lopez, VM
Martin, JJD
de Carpi, JM
author Trevino, SJ
author_facet Trevino, SJ
Muncunill, GP
Martin-Masot, R
Martinez, AR
Canton, OS
Quintana, LP
Ramos, HA
Arocena, FJE
Torres, JB
Burriel, JIG
Castillo, LO
Aliaga, ED
Martinez, VC
Garcia, PB
Arcos, GB
Porro, JMB
Ruiz, MJ
Sangrador, CO
Casales, ZG
Poblet, GG
Goicolea, PO
Garrido, HL
Romero, RG
Izquierdo, EL
Solis, DP
Navas-Lopez, VM
Martin, JJD
de Carpi, JM
author_role author
author2 Muncunill, GP
Martin-Masot, R
Martinez, AR
Canton, OS
Quintana, LP
Ramos, HA
Arocena, FJE
Torres, JB
Burriel, JIG
Castillo, LO
Aliaga, ED
Martinez, VC
Garcia, PB
Arcos, GB
Porro, JMB
Ruiz, MJ
Sangrador, CO
Casales, ZG
Poblet, GG
Goicolea, PO
Garrido, HL
Romero, RG
Izquierdo, EL
Solis, DP
Navas-Lopez, VM
Martin, JJD
de Carpi, JM
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv inflammatory bowel disease
Crohn&apos
s disease
ulcerative colitis
diagnostic delay
time to diagnosis
children
topic inflammatory bowel disease
Crohn&apos
s disease
ulcerative colitis
diagnostic delay
time to diagnosis
children
description Background and Aims: Diagnostic delay (DD) is especially relevant in children with inflammatory bowel disease, leading to potential complications. We examined the intervals and factors for DD in the pediatric population of Spain. Methods: We conducted a multicentric prospective study, including 149 pediatric inflammatory bowel disease patients, obtaining clinical, anthropometric, and biochemical data. Time to diagnosis (TD) was divided into several intervals to identify those where the DD was longer and find the variables that prolonged those intervals. Missed opportunities for diagnosis (MODs) were also identified. Results: Overall TD was 4.4 months (interquartile range [IQR] 2.6-10.4), being significantly higher in Crohn's disease (CD) than in ulcerative colitis (UC) (6.3 [IQR 3.3-12.3] vs. 3 [IQR 1.6-5.6] months, p = 0.0001). Time from the visit to the first physician until referral to a pediatric gastroenterologist was the main contributor to TD (2.4 months [IQR 1.03-7.17] in CD vs. 0.83 months [IQR 0.30-2.50] in UC, p = 0.0001). One hundred and ten patients (78.3%) visited more than one physician (29.9% to 4 or more), and 16.3% visited the same physician more than six times before being assessed by the pediatric gastroenterologist. The number of MODs was significantly higher in CD than that in UC patients: 4 MODs (IQR 2-7) vs. 2 MODs ([IQR 1-5], p = 0.003). Referral by pediatricians from hospital care allowed earlier IBD diagnosis (odds ratio 3.2 [95% confidence interval 1.1-8.9], p = 0.025). Conclusions: TD and DD were significantly higher in CD than those in UC. IBD patients (especially those with CD) undergo a large number of medical visits until the final diagnosis.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/8566
url https://fisabio.portalinvestigacion.com/publicaciones/8566
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv FRONTIERS MEDIA SA
publisher.none.fl_str_mv FRONTIERS MEDIA SA
dc.source.none.fl_str_mv Frontiers in Pediatrics
ISSN: 22962360
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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